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- W2769443178 abstract "Background: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and is advanced by severe viral hepatitis B or C (HBV or HCV). HCC is frequently diagnosed late requiring costly surgical resection or transplantation. Alpha fetoprotein (AFP) measurements, together with ultrasound are the most non-invasive methods for detection of HCC. Also, serum levels of hepatocyte growth factor (HGF) vary in liver diseases, reflecting hepatic damage and hepatocellular dysfunction. The discovery of miRNAs circulating in the peripheral blood has opened new directions of research to identify new non-invasive markers for diagnosis of diseases . Objectives: To assess the serum level of HGF and AFP in patients with liver cirrhosis with HCV infection and those of HCC .Also, to evaluate the expression levels of circulating plasma miRNA-122 in Egyptian patients. Methodology: Anti-HCV and HCV RNA were detected by an enzyme immunoassay and the viral RNA mini kit respectively among patients with cirrhosis and HCC. Also, serum AFP and HGF concentration was measured by sandwich ELISA for patients with HCC, patients with cirrhosis and normal controls. Correlation between HGF levels AFP and biochemical (transaminases, prothrombin activity, albumin, bilirubin), or virological (hepatitis C virus load) parameters was analyzed. . Expression level of miRNA-122 in plasma using RT-PCR were determined. Results: The serum AFP level was significantly elevated in cirrhotic and HCC patients in comparison to the control, with the highest level in the HCC group. On the other hand, the HGF level was significantly higher in HCC group than patients with cirrhosis. For HGF, the sensitivity and specificity were better than AFP (95% and 80% respectively). MiRNA-122 showed significant elevation in patients with cirrhosis groups and HCC group (P = 0.001) in comparison to the control group. Receiver operator characteristic (ROC) curve analysis for miRNA-122 yielded 73% sensitivity and 96 % specificity for the differentiation of HCC patients from non-HCC at a cutoff 0.165. Conclusion: HGF was better than AFP as noninvasive biomarkers for the detection of HCC in HCV cirrhotic patients. As its specificity was 96 %. MiRNA-122 can be used as novel non-invasive biomarker for monitoring HCV related disease progression." @default.
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- W2769443178 date "2017-10-01" @default.
- W2769443178 modified "2023-09-26" @default.
- W2769443178 title "Clinical Significance of AFP, HGF and Micro RNA-122 Levels in Patients with Liver Cirrhosis and Hepatocellular Carcinoma" @default.
- W2769443178 doi "https://doi.org/10.12816/0046258" @default.
- W2769443178 hasPublicationYear "2017" @default.
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