FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2769453185> ?p ?o ?g. }

• W2769453185 endingPage "80" @default.
• W2769453185 startingPage "75" @default.
• W2769453185 abstract "Apigenin is a natural flavonoid compound that has antioxidative, anti-inflammatory, and hepatoprotective effects, but the underlying mechanisms are still unclear. In this study, the effects of apigenin on ethanol-induced oxidative stress and lipopolysaccharide (LPS)-induced inflammatory cytokine production were examined in cultured rat hepatocytes. Following pretreatment of ethanol-stimulated hepatocytes with apigenin 6-24 mM for 2 h, the levels of cytochrome P450 2E1 (CYP2E1) protein expression and supernatant alanine aminotransferase and malondialdehyde were reduced (P < 0.05 or P < 0.01), while the activities of glutathione reductase and glutathione peroxidase were increased (P < 0.05 or P < 0.01). Likewise, the pretreatment of LPS-stimulated hepatocytes with the same concentrations of apigenin could decrease the levels of nuclear factor-κB protein expression and supernatant tumor necrosis factor-α and interleukin-6 (P < 0.05 or P < 0.01), and increase the level of IκB-α protein expression (P < 0.05 or P < 0.01). In all of these results, the concentration of 24 μM was the most effective. These findings demonstrate that apigenin may exert an inhibitory effect on ethanol-induced oxidative stress and LPS-induced inflammation in the cultured hepatocytes, and its mechanisms may be related to the reduction of CYP2E1 expression, increment of antioxidative ability, and regulation of inflammatory gene expression." @default.
• W2769453185 created "2017-12-04" @default.
• W2769453185 creator A5023480337 @default.
• W2769453185 creator A5029607305 @default.
• W2769453185 creator A5038405578 @default.
• W2769453185 creator A5045282548 @default.
• W2769453185 creator A5069464278 @default.
• W2769453185 date "2018-02-01" @default.
• W2769453185 modified "2023-10-18" @default.
• W2769453185 title "Apigenin inhibits ethanol-induced oxidative stress and LPS-induced inflammatory cytokine production in cultured rat hepatocytes" @default.
• W2769453185 cites W1750804103 @default.
• W2769453185 cites W1960809236 @default.
• W2769453185 cites W1976370364 @default.
• W2769453185 cites W1978364601 @default.
• W2769453185 cites W1979894411 @default.
• W2769453185 cites W1986678637 @default.
• W2769453185 cites W2002190789 @default.
• W2769453185 cites W2016894934 @default.
• W2769453185 cites W2025974944 @default.
• W2769453185 cites W2036015712 @default.
• W2769453185 cites W2041021896 @default.
• W2769453185 cites W2055913792 @default.
• W2769453185 cites W2062366543 @default.
• W2769453185 cites W2074973696 @default.
• W2769453185 cites W2077891956 @default.
• W2769453185 cites W2081687035 @default.
• W2769453185 cites W2087459059 @default.
• W2769453185 cites W2098979202 @default.
• W2769453185 cites W2101568779 @default.
• W2769453185 cites W2119928071 @default.
• W2769453185 cites W2163853440 @default.
• W2769453185 cites W2164180982 @default.
• W2769453185 cites W2509950322 @default.
• W2769453185 cites W2513407592 @default.
• W2769453185 cites W2515162732 @default.
• W2769453185 cites W2604637217 @default.
• W2769453185 cites W2618250141 @default.
• W2769453185 doi "https://doi.org/10.1016/j.jab.2017.11.006" @default.
• W2769453185 hasPublicationYear "2018" @default.
• W2769453185 type Work @default.
• W2769453185 sameAs 2769453185 @default.
• W2769453185 citedByCount "13" @default.
• W2769453185 countsByYear W27694531852019 @default.
• W2769453185 countsByYear W27694531852020 @default.
• W2769453185 countsByYear W27694531852021 @default.
• W2769453185 countsByYear W27694531852022 @default.
• W2769453185 crossrefType "journal-article" @default.
• W2769453185 hasAuthorship W2769453185A5023480337 @default.
• W2769453185 hasAuthorship W2769453185A5029607305 @default.
• W2769453185 hasAuthorship W2769453185A5038405578 @default.
• W2769453185 hasAuthorship W2769453185A5045282548 @default.
• W2769453185 hasAuthorship W2769453185A5069464278 @default.
• W2769453185 hasConcept C134018914 @default.
• W2769453185 hasConcept C140027455 @default.
• W2769453185 hasConcept C17991360 @default.
• W2769453185 hasConcept C181199279 @default.
• W2769453185 hasConcept C185592680 @default.
• W2769453185 hasConcept C203014093 @default.
• W2769453185 hasConcept C2775838275 @default.
• W2769453185 hasConcept C2776080593 @default.
• W2769453185 hasConcept C2776151105 @default.
• W2769453185 hasConcept C2778004101 @default.
• W2769453185 hasConcept C2778401633 @default.
• W2769453185 hasConcept C2778609962 @default.
• W2769453185 hasConcept C2778690821 @default.
• W2769453185 hasConcept C2778754761 @default.
• W2769453185 hasConcept C2778760513 @default.
• W2769453185 hasConcept C2779054382 @default.
• W2769453185 hasConcept C526171541 @default.
• W2769453185 hasConcept C538909803 @default.
• W2769453185 hasConcept C55493867 @default.
• W2769453185 hasConcept C86803240 @default.
• W2769453185 hasConcept C98274493 @default.
• W2769453185 hasConceptScore W2769453185C134018914 @default.
• W2769453185 hasConceptScore W2769453185C140027455 @default.
• W2769453185 hasConceptScore W2769453185C17991360 @default.
• W2769453185 hasConceptScore W2769453185C181199279 @default.
• W2769453185 hasConceptScore W2769453185C185592680 @default.
• W2769453185 hasConceptScore W2769453185C203014093 @default.
• W2769453185 hasConceptScore W2769453185C2775838275 @default.
• W2769453185 hasConceptScore W2769453185C2776080593 @default.
• W2769453185 hasConceptScore W2769453185C2776151105 @default.
• W2769453185 hasConceptScore W2769453185C2778004101 @default.
• W2769453185 hasConceptScore W2769453185C2778401633 @default.
• W2769453185 hasConceptScore W2769453185C2778609962 @default.
• W2769453185 hasConceptScore W2769453185C2778690821 @default.
• W2769453185 hasConceptScore W2769453185C2778754761 @default.
• W2769453185 hasConceptScore W2769453185C2778760513 @default.
• W2769453185 hasConceptScore W2769453185C2779054382 @default.
• W2769453185 hasConceptScore W2769453185C526171541 @default.
• W2769453185 hasConceptScore W2769453185C538909803 @default.
• W2769453185 hasConceptScore W2769453185C55493867 @default.
• W2769453185 hasConceptScore W2769453185C86803240 @default.
• W2769453185 hasConceptScore W2769453185C98274493 @default.
• W2769453185 hasIssue "1" @default.
• W2769453185 hasLocation W27694531851 @default.
• W2769453185 hasOpenAccess W2769453185 @default.
• W2769453185 hasPrimaryLocation W27694531851 @default.

• next