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• W2769469360 abstract "Reversible protein phosphorylation is one of the major mechanisms in the regulation of protein expression and protein activity, controlling physiological functions of the important human pathogen Staphylococcus aureus. Phosphorylations at serine, threonine and tyrosine are known to influence for example protein activity in central metabolic pathways and the more energy-rich phosphorylations at histidine, aspartate or cysteine can be found as part of two component system sensor domains or mediating bacterial virulence. In addition to these well-known phosphorylations, the phosphorylation at arginine residues plays an essential role. Hence, the deletion mutant S. aureus COL ΔptpB (protein tyrosine phosphatase B) was studied because the protein PtpB is assumed to be an arginine phosphatase. A gel-free approach was applied to analyze the changes in the phosphoproteome of the deletion mutant ΔptpB and the wild type in growing cells, thereby focusing on the occurrence of phosphorylation on arginine residues. In order to enhance the reliability of identified phosphorylation sites at arginine residues, a subset of arginine phosphorylated peptides was chemically synthesized. Combined spectral libraries based on phosphoenriched samples, synthetic arginine phosphorylated peptides and classical proteome samples provide a sophisticated tool for the analysis of arginine phosphorylations. This way, 212 proteins phosphorylated on serine, threonine, tyrosine or arginine residues were identified within the mutant ΔptpB and 102 in wild type samples. Among them, 207 arginine phosphosites were identified exclusively within the mutant ΔptpB, widely distributed along the whole bacterial metabolism. This identification of putative targets of PtpB allows further investigation of the physiological relevance of arginine phosphorylations and provides the basis for reliable quantification of arginine phosphorylations in bacteria." @default.
• W2769469360 created "2017-12-04" @default.
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• W2769469360 date "2018-02-01" @default.
• W2769469360 modified "2023-10-17" @default.
• W2769469360 title "Spectral Library Based Analysis of Arginine Phosphorylations in Staphylococcus aureus" @default.
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• W2769469360 doi "https://doi.org/10.1074/mcp.ra117.000378" @default.
• W2769469360 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5795395" @default.
• W2769469360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29183913" @default.
• W2769469360 hasPublicationYear "2018" @default.
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