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• W2769481421 abstract "Much of the controversy surrounding the induction of locomotion following stimulation of mesopontine sites, including the pedunculopontine nucleus (PPN), appears based on procedural differences, including stimulus onset, delay preceding stepping, and frequency of stimuli. The results reviewed in this chapter address these issues and provide novel information suggesting that descending projections from the PPN may exert a frequency-dependent effect. Stimulation at approximately 60 Hz (which induces prolonged tonic firing) may exercise a push towards locomotion (activation of pontine interneurons) as well as a pull away from decreased muscle tone (inhibiting giant pontine reticulospinal cells). Higher frequencies of stimulation (> 100 Hz, which induces phasic burst-like activity) may push towards decreases in muscle tone, including the atonia of rapid eye movement sleep (activating giant pontine reticulospinal cells)." @default.
• W2769481421 created "2017-12-04" @default.
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• W2769481421 date "2004-01-01" @default.
• W2769481421 modified "2023-10-18" @default.
• W2769481421 title "Arousal mechanisms related to posture and locomotion: 2. Ascending modulation" @default.
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• W2769481421 doi "https://doi.org/10.1016/s0079-6123(03)43028-8" @default.
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