FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2769489330> ?p ?o ?g. }

• W2769489330 abstract "Temozolomide (TMZ) is a drug that has been demonstrated to improve the survival time of patients with glioblastoma multiforme (GBM) when administered with concomitant radiotherapy. However, chemoresistance is one of the major obstacles in the treatment of GBM. In the present study, an MTT assay and flow cytometry were used to demonstrate that chlorotoxin‑like toxin in the venom of the scorpion Buthus martensii Kirsch (BmK CT) markedly inhibited cell proliferation and induced apoptosis in U251 cells when combined with TMZ. In combination with TMZ, BmK CT exhibited a significant and synergistic anti‑tumor effect by inhibiting protein kinase B (AKT) independently and triggering the apoptosis signaling cascade in vitro. Furthermore, BmK CT increased the expression of phosphatase and tensin homolog at the transcriptional level, which is a key negative regulator of the AKT signaling pathway. The results of the present study demonstrated that BmK CT enhanced the sensitivity of TMZ‑induced U251 cell apoptosis through the downregulation of phosphorylated AKT levels, suggesting that BmK CT and TMZ combination therapy may be a novel approach for glioma therapy." @default.
• W2769489330 created "2017-12-04" @default.
• W2769489330 creator A5005962127 @default.
• W2769489330 creator A5006893498 @default.
• W2769489330 creator A5030006004 @default.
• W2769489330 creator A5040659539 @default.
• W2769489330 creator A5054655736 @default.
• W2769489330 creator A5058814917 @default.
• W2769489330 creator A5087363413 @default.
• W2769489330 date "2017-11-24" @default.
• W2769489330 modified "2023-10-18" @default.
• W2769489330 title "BmK CT enhances the sensitivity of temozolomide-induced apoptosis of malignant glioma U251 cells in�vitro through blocking the AKT signaling pathway" @default.
• W2769489330 cites W1487234933 @default.
• W2769489330 cites W1677659983 @default.
• W2769489330 cites W1976779081 @default.
• W2769489330 cites W1984418041 @default.
• W2769489330 cites W1995806069 @default.
• W2769489330 cites W1997199834 @default.
• W2769489330 cites W2056753605 @default.
• W2769489330 cites W2065919583 @default.
• W2769489330 cites W2080686007 @default.
• W2769489330 cites W2081051374 @default.
• W2769489330 cites W2100959692 @default.
• W2769489330 cites W2106981708 @default.
• W2769489330 cites W2107277218 @default.
• W2769489330 cites W2113158807 @default.
• W2769489330 cites W2115862526 @default.
• W2769489330 cites W2135462171 @default.
• W2769489330 cites W2147129352 @default.
• W2769489330 cites W2167780449 @default.
• W2769489330 cites W2192080449 @default.
• W2769489330 cites W2267448968 @default.
• W2769489330 cites W2277371204 @default.
• W2769489330 cites W2295059886 @default.
• W2769489330 cites W2519335715 @default.
• W2769489330 cites W2582215354 @default.
• W2769489330 doi "https://doi.org/10.3892/ol.2017.7483" @default.
• W2769489330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5774446" @default.
• W2769489330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29434848" @default.
• W2769489330 hasPublicationYear "2017" @default.
• W2769489330 type Work @default.
• W2769489330 sameAs 2769489330 @default.
• W2769489330 citedByCount "3" @default.
• W2769489330 countsByYear W27694893302018 @default.
• W2769489330 countsByYear W27694893302021 @default.
• W2769489330 countsByYear W27694893302023 @default.
• W2769489330 crossrefType "journal-article" @default.
• W2769489330 hasAuthorship W2769489330A5005962127 @default.
• W2769489330 hasAuthorship W2769489330A5006893498 @default.
• W2769489330 hasAuthorship W2769489330A5030006004 @default.
• W2769489330 hasAuthorship W2769489330A5040659539 @default.
• W2769489330 hasAuthorship W2769489330A5054655736 @default.
• W2769489330 hasAuthorship W2769489330A5058814917 @default.
• W2769489330 hasAuthorship W2769489330A5087363413 @default.
• W2769489330 hasBestOaLocation W27694893301 @default.
• W2769489330 hasConcept C185592680 @default.
• W2769489330 hasConcept C190283241 @default.
• W2769489330 hasConcept C2777389519 @default.
• W2769489330 hasConcept C2777609662 @default.
• W2769489330 hasConcept C2778227246 @default.
• W2769489330 hasConcept C2781018059 @default.
• W2769489330 hasConcept C29537977 @default.
• W2769489330 hasConcept C502942594 @default.
• W2769489330 hasConcept C55493867 @default.
• W2769489330 hasConcept C62112901 @default.
• W2769489330 hasConcept C75217442 @default.
• W2769489330 hasConcept C86554907 @default.
• W2769489330 hasConcept C86803240 @default.
• W2769489330 hasConceptScore W2769489330C185592680 @default.
• W2769489330 hasConceptScore W2769489330C190283241 @default.
• W2769489330 hasConceptScore W2769489330C2777389519 @default.
• W2769489330 hasConceptScore W2769489330C2777609662 @default.
• W2769489330 hasConceptScore W2769489330C2778227246 @default.
• W2769489330 hasConceptScore W2769489330C2781018059 @default.
• W2769489330 hasConceptScore W2769489330C29537977 @default.
• W2769489330 hasConceptScore W2769489330C502942594 @default.
• W2769489330 hasConceptScore W2769489330C55493867 @default.
• W2769489330 hasConceptScore W2769489330C62112901 @default.
• W2769489330 hasConceptScore W2769489330C75217442 @default.
• W2769489330 hasConceptScore W2769489330C86554907 @default.
• W2769489330 hasConceptScore W2769489330C86803240 @default.
• W2769489330 hasLocation W27694893301 @default.
• W2769489330 hasLocation W27694893302 @default.
• W2769489330 hasLocation W27694893303 @default.
• W2769489330 hasLocation W27694893304 @default.
• W2769489330 hasOpenAccess W2769489330 @default.
• W2769489330 hasPrimaryLocation W27694893301 @default.
• W2769489330 hasRelatedWork W2074517075 @default.
• W2769489330 hasRelatedWork W2123602693 @default.
• W2769489330 hasRelatedWork W2186081307 @default.
• W2769489330 hasRelatedWork W2235074116 @default.
• W2769489330 hasRelatedWork W2805657231 @default.
• W2769489330 hasRelatedWork W2884617011 @default.
• W2769489330 hasRelatedWork W2988175535 @default.
• W2769489330 hasRelatedWork W3044672584 @default.
• W2769489330 hasRelatedWork W3146426108 @default.
• W2769489330 hasRelatedWork W4255321854 @default.
• W2769489330 isParatext "false" @default.
• W2769489330 isRetracted "false" @default.
• W2769489330 magId "2769489330" @default.

• next