FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2769492099> ?p ?o ?g. }

• W2769492099 endingPage "e650" @default.
• W2769492099 startingPage "e643" @default.
• W2769492099 abstract "Wild type p53-induced phosphatase 1 (Wip1), encoded by the protein phosphatase magnesium dependent 1 delta (PPM1D), inhibits p53. PPM1D amplification has been reported in breast cancer. Breast cancer can sometimes develop without a tumor protein 53 (TP53) mutation. In these cases, the p53 pathway might be disrupted by alternative mechanisms, and Wip1 is reported to be a key molecule involved.Primary invasive ductal carcinoma specimens were obtained from 201 cases, for which archival tissue samples for immunohistochemistry were available. We evaluated Wip1 and p21 protein expression (201 cases), Wip1 mRNA expression (63 cases), PPM1D DNA copy number (71 cases) and TP53 status (36 cases) using available samples among the 201 cases, and analyzed their relationships with clinicopathological factors and prognosis.The nuclear expression of Wip1 protein was positive in 21 cases (10.4%). The PPM1D DNA copy number was significantly correlated with Wip1 protein expression. All cases with PPM1D amplification by single-nucleotide polymorphism comparative genomic hybridization array showed positive nuclear Wip1 expression. Wip1 protein expression was positively correlated with p21 expression. The tumors with positive Wip1 and negative p21 expression showed the poorest prognosis among all tumor types.The protein expression of Wip1 might be regulated by PPM1D amplification, independent of TP53 status. Positive Wip1 and negative p21 expression was associated with the poorest prognosis and suggests the loss of p53 function." @default.
• W2769492099 created "2017-12-04" @default.
• W2769492099 creator A5004420462 @default.
• W2769492099 creator A5011644667 @default.
• W2769492099 creator A5018750173 @default.
• W2769492099 creator A5023334776 @default.
• W2769492099 creator A5049884976 @default.
• W2769492099 creator A5063723368 @default.
• W2769492099 creator A5072378382 @default.
• W2769492099 creator A5073012541 @default.
• W2769492099 creator A5075105508 @default.
• W2769492099 date "2018-08-01" @default.
• W2769492099 modified "2023-10-16" @default.
• W2769492099 title "Clinical Significance of the Wild Type p53-Induced Phosphatase 1 Expression in Invasive Breast Cancer" @default.
• W2769492099 cites W1519748651 @default.
• W2769492099 cites W1650797637 @default.
• W2769492099 cites W1841003668 @default.
• W2769492099 cites W1955123431 @default.
• W2769492099 cites W1970329931 @default.
• W2769492099 cites W1973268693 @default.
• W2769492099 cites W1975554249 @default.
• W2769492099 cites W1976873804 @default.
• W2769492099 cites W1978518304 @default.
• W2769492099 cites W1980027449 @default.
• W2769492099 cites W1982076272 @default.
• W2769492099 cites W1984886864 @default.
• W2769492099 cites W1991494214 @default.
• W2769492099 cites W1997846839 @default.
• W2769492099 cites W1999285644 @default.
• W2769492099 cites W2000034979 @default.
• W2769492099 cites W2012907769 @default.
• W2769492099 cites W2014720385 @default.
• W2769492099 cites W2015519364 @default.
• W2769492099 cites W2024074560 @default.
• W2769492099 cites W2039000907 @default.
• W2769492099 cites W2039030772 @default.
• W2769492099 cites W2040169548 @default.
• W2769492099 cites W2041589509 @default.
• W2769492099 cites W2049475256 @default.
• W2769492099 cites W2050981751 @default.
• W2769492099 cites W2054311839 @default.
• W2769492099 cites W2074364031 @default.
• W2769492099 cites W2079706088 @default.
• W2769492099 cites W2088308108 @default.
• W2769492099 cites W2091330544 @default.
• W2769492099 cites W2093775600 @default.
• W2769492099 cites W2110793364 @default.
• W2769492099 cites W2122438081 @default.
• W2769492099 cites W2127057139 @default.
• W2769492099 cites W2133959309 @default.
• W2769492099 cites W2141973741 @default.
• W2769492099 cites W2149013144 @default.
• W2769492099 cites W2150097377 @default.
• W2769492099 cites W2159796173 @default.
• W2769492099 cites W2162262059 @default.
• W2769492099 cites W2171407623 @default.
• W2769492099 cites W2255041504 @default.
• W2769492099 cites W2291974241 @default.
• W2769492099 cites W2382465108 @default.
• W2769492099 cites W2564577996 @default.
• W2769492099 doi "https://doi.org/10.1016/j.clbc.2017.11.008" @default.
• W2769492099 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29275106" @default.
• W2769492099 hasPublicationYear "2018" @default.
• W2769492099 type Work @default.
• W2769492099 sameAs 2769492099 @default.
• W2769492099 citedByCount "5" @default.
• W2769492099 countsByYear W27694920992019 @default.
• W2769492099 countsByYear W27694920992020 @default.
• W2769492099 countsByYear W27694920992021 @default.
• W2769492099 countsByYear W27694920992022 @default.
• W2769492099 crossrefType "journal-article" @default.
• W2769492099 hasAuthorship W2769492099A5004420462 @default.
• W2769492099 hasAuthorship W2769492099A5011644667 @default.
• W2769492099 hasAuthorship W2769492099A5018750173 @default.
• W2769492099 hasAuthorship W2769492099A5023334776 @default.
• W2769492099 hasAuthorship W2769492099A5049884976 @default.
• W2769492099 hasAuthorship W2769492099A5063723368 @default.
• W2769492099 hasAuthorship W2769492099A5072378382 @default.
• W2769492099 hasAuthorship W2769492099A5073012541 @default.
• W2769492099 hasAuthorship W2769492099A5075105508 @default.
• W2769492099 hasBestOaLocation W27694920992 @default.
• W2769492099 hasConcept C104317684 @default.
• W2769492099 hasConcept C11960822 @default.
• W2769492099 hasConcept C121608353 @default.
• W2769492099 hasConcept C124942203 @default.
• W2769492099 hasConcept C141231307 @default.
• W2769492099 hasConcept C142724271 @default.
• W2769492099 hasConcept C153911025 @default.
• W2769492099 hasConcept C178666793 @default.
• W2769492099 hasConcept C204232928 @default.
• W2769492099 hasConcept C502942594 @default.
• W2769492099 hasConcept C530470458 @default.
• W2769492099 hasConcept C54355233 @default.
• W2769492099 hasConcept C71924100 @default.
• W2769492099 hasConcept C86803240 @default.
• W2769492099 hasConceptScore W2769492099C104317684 @default.
• W2769492099 hasConceptScore W2769492099C11960822 @default.
• W2769492099 hasConceptScore W2769492099C121608353 @default.

• next