FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2769536415> ?p ?o ?g. }

• W2769536415 abstract "Rituximab had been shown to be effective in inducing remission of nephrotic syndrome in patients with idiopathic membranous nephropathy (iMN). This study applied rituximab therapy for 36 non-responsive iMN patients to investigate its effects and safety. Thirty-six iMN patients who were non-responsive to prior immunosuppression were enrolled. Rituximab was used for B-cell depletion in patients, with a goal of <5 B cells/mm3 in the circulation. After completing the study, patients were monitored for a median of 12.0 months [interquartile range (IQR) 9.0–19.3]. Fifteen of the 36 (41.7%) patients achieved partial (n = 13) or complete (n = 2) response to the rituximab treatment. The median time for achieving partial response was 4.0 months (IQR 3.0–6.0). The responders had relatively lower levels (118 ± 112 U/mL versus 345 ± 357 U/mL, P = 0.03) of anti-phospholipase 2 receptor (PLA2R) antibodies before the rituximab treatment, and all of them achieved antibody depletion or reduction. B-cell depletion was achieved in all patients. Renal function remained stable in the responders [estimated glomerular filtration rate (eGFR) 53.3 ± 40.5 versus 55.6 ± 33.2 mL/min/1.73 m2, P = 0.67] but deteriorated in the non-responders (eGFR 57.5 ± 29.3 versus 45.3 ± 32.8 mL/min/1.73 m2, P = 0.02) with two patients reaching end-stage kidney disease. Two of the 15 patients relapsed during the follow-up period with anti-PLA2R antibody reoccurrence and B-cell reconstitution. The second course of rituximab combined with tacrolimus induced a faster partial response again in one patient. Rituximab therapy could induce remission of proteinuria and stabilization of renal function in non-responsive iMN patients, even those with damaged renal function. Anti-PLA2R antibodies may be used as a marker for individualized rituximab dosage and treatment monitoring." @default.
• W2769536415 created "2017-12-04" @default.
• W2769536415 creator A5006822602 @default.
• W2769536415 creator A5008236609 @default.
• W2769536415 creator A5031656017 @default.
• W2769536415 creator A5040356293 @default.
• W2769536415 creator A5050406385 @default.
• W2769536415 creator A5074328979 @default.
• W2769536415 creator A5075545173 @default.
• W2769536415 creator A5082289997 @default.
• W2769536415 creator A5085801296 @default.
• W2769536415 creator A5036653865 @default.
• W2769536415 date "2017-11-14" @default.
• W2769536415 modified "2023-10-18" @default.
• W2769536415 title "Rituximab for non-responsive idiopathic membranous nephropathy in a Chinese cohort" @default.
• W2769536415 cites W1528700368 @default.
• W2769536415 cites W1561926765 @default.
• W2769536415 cites W1565220551 @default.
• W2769536415 cites W2011460189 @default.
• W2769536415 cites W2018459774 @default.
• W2769536415 cites W2034585575 @default.
• W2769536415 cites W2089916413 @default.
• W2769536415 cites W2122581834 @default.
• W2769536415 cites W2127127482 @default.
• W2769536415 cites W2131815197 @default.
• W2769536415 cites W2133344401 @default.
• W2769536415 cites W2140565611 @default.
• W2769536415 cites W2157296439 @default.
• W2769536415 cites W2166822765 @default.
• W2769536415 cites W2429519160 @default.
• W2769536415 cites W2470335436 @default.
• W2769536415 doi "https://doi.org/10.1093/ndt/gfx295" @default.
• W2769536415 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29149305" @default.
• W2769536415 hasPublicationYear "2017" @default.
• W2769536415 type Work @default.
• W2769536415 sameAs 2769536415 @default.
• W2769536415 citedByCount "28" @default.
• W2769536415 countsByYear W27695364152018 @default.
• W2769536415 countsByYear W27695364152019 @default.
• W2769536415 countsByYear W27695364152020 @default.
• W2769536415 countsByYear W27695364152021 @default.
• W2769536415 countsByYear W27695364152022 @default.
• W2769536415 countsByYear W27695364152023 @default.
• W2769536415 crossrefType "journal-article" @default.
• W2769536415 hasAuthorship W2769536415A5006822602 @default.
• W2769536415 hasAuthorship W2769536415A5008236609 @default.
• W2769536415 hasAuthorship W2769536415A5031656017 @default.
• W2769536415 hasAuthorship W2769536415A5036653865 @default.
• W2769536415 hasAuthorship W2769536415A5040356293 @default.
• W2769536415 hasAuthorship W2769536415A5050406385 @default.
• W2769536415 hasAuthorship W2769536415A5074328979 @default.
• W2769536415 hasAuthorship W2769536415A5075545173 @default.
• W2769536415 hasAuthorship W2769536415A5082289997 @default.
• W2769536415 hasAuthorship W2769536415A5085801296 @default.
• W2769536415 hasBestOaLocation W27695364151 @default.
• W2769536415 hasConcept C119060515 @default.
• W2769536415 hasConcept C126322002 @default.
• W2769536415 hasConcept C126894567 @default.
• W2769536415 hasConcept C141071460 @default.
• W2769536415 hasConcept C159641895 @default.
• W2769536415 hasConcept C159654299 @default.
• W2769536415 hasConcept C203014093 @default.
• W2769536415 hasConcept C2775946357 @default.
• W2769536415 hasConcept C2778653478 @default.
• W2769536415 hasConcept C2778930706 @default.
• W2769536415 hasConcept C2780091579 @default.
• W2769536415 hasConcept C2780252810 @default.
• W2769536415 hasConcept C2780368995 @default.
• W2769536415 hasConcept C2780653079 @default.
• W2769536415 hasConcept C71924100 @default.
• W2769536415 hasConcept C90924648 @default.
• W2769536415 hasConceptScore W2769536415C119060515 @default.
• W2769536415 hasConceptScore W2769536415C126322002 @default.
• W2769536415 hasConceptScore W2769536415C126894567 @default.
• W2769536415 hasConceptScore W2769536415C141071460 @default.
• W2769536415 hasConceptScore W2769536415C159641895 @default.
• W2769536415 hasConceptScore W2769536415C159654299 @default.
• W2769536415 hasConceptScore W2769536415C203014093 @default.
• W2769536415 hasConceptScore W2769536415C2775946357 @default.
• W2769536415 hasConceptScore W2769536415C2778653478 @default.
• W2769536415 hasConceptScore W2769536415C2778930706 @default.
• W2769536415 hasConceptScore W2769536415C2780091579 @default.
• W2769536415 hasConceptScore W2769536415C2780252810 @default.
• W2769536415 hasConceptScore W2769536415C2780368995 @default.
• W2769536415 hasConceptScore W2769536415C2780653079 @default.
• W2769536415 hasConceptScore W2769536415C71924100 @default.
• W2769536415 hasConceptScore W2769536415C90924648 @default.
• W2769536415 hasLocation W27695364151 @default.
• W2769536415 hasLocation W27695364152 @default.
• W2769536415 hasOpenAccess W2769536415 @default.
• W2769536415 hasPrimaryLocation W27695364151 @default.
• W2769536415 hasRelatedWork W1180775993 @default.
• W2769536415 hasRelatedWork W1550877063 @default.
• W2769536415 hasRelatedWork W1966718538 @default.
• W2769536415 hasRelatedWork W2942310551 @default.
• W2769536415 hasRelatedWork W2961197401 @default.
• W2769536415 hasRelatedWork W4323304723 @default.
• W2769536415 hasRelatedWork W4378745636 @default.
• W2769536415 hasRelatedWork W4381306438 @default.
• W2769536415 hasRelatedWork W4387415399 @default.

• next