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• W2769542964 abstract "Previous reports show that the desmosomal plaque protein plakophilin3 (PKP3) is essential for desmosome formation. Here, we report that PKP3 over-expression decreases calcium dependency for de novo desmosome formation and makes existing cell-cell adhesion junctions more resilient in low calcium medium due to an increase in desmocollin2 expression. PKP3 overexpression increases the stability of other desmosomal proteins independently of the increase in DSC2 levels and regulates desmosome formation and stability by a multimodal mechanism affecting transcription, protein stability and cell border localization of desmosomal proteins." @default.
• W2769542964 created "2017-12-04" @default.
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• W2769542964 date "2018-01-01" @default.
• W2769542964 modified "2023-09-29" @default.
• W2769542964 title "Plakophilin3 increases desmosome assembly, size and stability by increasing expression of desmocollin2" @default.
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• W2769542964 doi "https://doi.org/10.1016/j.bbrc.2017.11.085" @default.
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• W2769542964 hasPublicationYear "2018" @default.
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