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- W2769575341 abstract "Nuclear Magnetic Resonance spectroscopy is a highly resolutive method for drug-discovery as it provides information about drug association to a target protein, over a wide range of affinities and with atomic resolution. The binding event affects many NMR observables that are sensitive to the chemical environment and to putative changes in the structure/dynamics upon binding. The versatility and robustness of this technique explains why pharmaceutical and research groups routinely incorporate NMR spectroscopy into their high-throughput ligand screening strategies. In this chapter, we pay attention to the receptor-based NMR experiments that monitor the target protein to quantitatively describe and validate the small-compound binding phenomena." @default.
- W2769575341 created "2017-12-04" @default.
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- W2769575341 date "2017-11-20" @default.
- W2769575341 modified "2023-10-17" @default.
- W2769575341 title "Receptor-based NMR Techniques in Drug Discovery" @default.
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- W2769575341 doi "https://doi.org/10.1039/9781788010016-00044" @default.
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