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• W2769593867 abstract "The classification of neurons into distinct types is an ongoing effort aimed at revealing and understanding the diversity of the components of the nervous system. Recently available methods allow us to determine the gene expression pattern of individual neurons in the mammalian cerebral cortex to generate powerful categorization schemes. For a thorough understanding of neuronal diversity such genetic categorization schemes need to be combined with traditional classification parameters like position, axonal projection or response properties to sensory stimulation. Here we describe a method to link the gene expression of individual neurons with their position, axonal projection or sensory response properties. Neurons are labeled in vivo based on their anatomical or functional properties and, using patch clamp pipettes, their RNA individually harvested in vitro for RNAseq. We validate the methodology using multiple established molecularly and anatomically distinct cell populations and explore molecular differences between uncharacterized neurons in mouse visual cortex. Gene expression patterns between L5 neurons projecting to frontal or contralateral cortex are distinct while L2 neurons differing in position, projection or function are molecularly similar. With this method we can determine the genetic expression pattern of functionally and anatomically identified individual neurons." @default.
• W2769593867 created "2017-12-04" @default.
• W2769593867 creator A5000680718 @default.
• W2769593867 creator A5068830578 @default.
• W2769593867 date "2017-11-30" @default.
• W2769593867 modified "2023-10-05" @default.
• W2769593867 title "Correlating Anatomy and Function with Gene Expression in Individual Neurons by Combining in Vivo Labeling, Patch Clamp, and Single Cell RNA-seq" @default.
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• W2769593867 doi "https://doi.org/10.3389/fncel.2017.00376" @default.
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