Matches in SemOpenAlex for { <https://semopenalex.org/work/W2769630167> ?p ?o ?g. }
- W2769630167 endingPage "802" @default.
- W2769630167 startingPage "789" @default.
- W2769630167 abstract "Nicotine improves attention and processing speed in individuals with schizophrenia. Few studies have investigated the effects of nicotine on cognitive control. Prior functional magnetic resonance imaging (fMRI) research demonstrates blunted activation of dorsal anterior cingulate cortex (dACC) and rostral anterior cingulate cortex (rACC) in response to error and decreased post-error slowing in schizophrenia. Participants with schizophrenia (n = 13) and healthy controls (n = 12) participated in a randomized, placebo-controlled, crossover study of the effects of transdermal nicotine on cognitive control. For each drug condition, participants underwent fMRI while performing the stop signal task where participants attempt to inhibit prepotent responses to “go (motor activation)” signals when an occasional “stop (motor inhibition)” signal appears. Error processing was evaluated by comparing “stop error” trials (failed response inhibition) to “go” trials. Resting-state fMRI data were collected prior to the task. Participants with schizophrenia had increased nicotine-induced activation of right caudate in response to errors compared to controls (DRUG × GROUP effect: p corrected < 0.05). Both groups had significant nicotine-induced activation of dACC and rACC in response to errors. Using right caudate activation to errors as a seed for resting-state functional connectivity analysis, relative to controls, participants with schizophrenia had significantly decreased connectivity between the right caudate and dACC/bilateral dorsolateral prefrontal cortices. In sum, we replicated prior findings of decreased post-error slowing in schizophrenia and found that nicotine was associated with more adaptive (i.e., increased) post-error reaction time (RT). This proof-of-concept pilot study suggests a role for nicotinic agents in targeting cognitive control deficits in schizophrenia." @default.
- W2769630167 created "2017-12-04" @default.
- W2769630167 creator A5004560717 @default.
- W2769630167 creator A5007600208 @default.
- W2769630167 creator A5007719765 @default.
- W2769630167 creator A5018380909 @default.
- W2769630167 creator A5031422040 @default.
- W2769630167 creator A5036024107 @default.
- W2769630167 creator A5048298318 @default.
- W2769630167 creator A5069818712 @default.
- W2769630167 creator A5073880521 @default.
- W2769630167 creator A5075045747 @default.
- W2769630167 creator A5085272654 @default.
- W2769630167 date "2017-11-27" @default.
- W2769630167 modified "2023-10-17" @default.
- W2769630167 title "Nicotine-induced activation of caudate and anterior cingulate cortex in response to errors in schizophrenia" @default.
- W2769630167 cites W1694363227 @default.
- W2769630167 cites W1896170447 @default.
- W2769630167 cites W1965198880 @default.
- W2769630167 cites W1971969868 @default.
- W2769630167 cites W1975448160 @default.
- W2769630167 cites W1987420884 @default.
- W2769630167 cites W1988473888 @default.
- W2769630167 cites W1990134753 @default.
- W2769630167 cites W1993560189 @default.
- W2769630167 cites W1996406422 @default.
- W2769630167 cites W1999984108 @default.
- W2769630167 cites W2005525607 @default.
- W2769630167 cites W2008792759 @default.
- W2769630167 cites W2010421643 @default.
- W2769630167 cites W2012007142 @default.
- W2769630167 cites W2014088563 @default.
- W2769630167 cites W2015335162 @default.
- W2769630167 cites W2016023712 @default.
- W2769630167 cites W2017709022 @default.
- W2769630167 cites W2019351781 @default.
- W2769630167 cites W2019616095 @default.
- W2769630167 cites W2021139758 @default.
- W2769630167 cites W2022320465 @default.
- W2769630167 cites W2023076733 @default.
- W2769630167 cites W2026482820 @default.
- W2769630167 cites W2030600687 @default.
- W2769630167 cites W2035146011 @default.
- W2769630167 cites W2039729702 @default.
- W2769630167 cites W2043377857 @default.
- W2769630167 cites W2044328149 @default.
- W2769630167 cites W2055665362 @default.
- W2769630167 cites W2057046889 @default.
- W2769630167 cites W2060881658 @default.
- W2769630167 cites W2061756585 @default.
- W2769630167 cites W2065127840 @default.
- W2769630167 cites W2068327720 @default.
- W2769630167 cites W2070812752 @default.
- W2769630167 cites W2071300176 @default.
- W2769630167 cites W2078069463 @default.
- W2769630167 cites W2082714165 @default.
- W2769630167 cites W2084399151 @default.
- W2769630167 cites W2097137621 @default.
- W2769630167 cites W2097212739 @default.
- W2769630167 cites W2101264293 @default.
- W2769630167 cites W2103145130 @default.
- W2769630167 cites W2105795954 @default.
- W2769630167 cites W2106592748 @default.
- W2769630167 cites W2112020021 @default.
- W2769630167 cites W2112138490 @default.
- W2769630167 cites W2114862449 @default.
- W2769630167 cites W2118061336 @default.
- W2769630167 cites W2121233440 @default.
- W2769630167 cites W2122502474 @default.
- W2769630167 cites W2124906793 @default.
- W2769630167 cites W2125823313 @default.
- W2769630167 cites W2127830759 @default.
- W2769630167 cites W2129457500 @default.
- W2769630167 cites W2130010412 @default.
- W2769630167 cites W2132175842 @default.
- W2769630167 cites W2134108978 @default.
- W2769630167 cites W2136998407 @default.
- W2769630167 cites W2140909692 @default.
- W2769630167 cites W2141387599 @default.
- W2769630167 cites W2142458433 @default.
- W2769630167 cites W2151505978 @default.
- W2769630167 cites W2156436903 @default.
- W2769630167 cites W2157815289 @default.
- W2769630167 cites W2161225754 @default.
- W2769630167 cites W2161780394 @default.
- W2769630167 cites W2163452374 @default.
- W2769630167 cites W2165965440 @default.
- W2769630167 cites W2172201169 @default.
- W2769630167 cites W2253752583 @default.
- W2769630167 cites W2270526286 @default.
- W2769630167 cites W2395200172 @default.
- W2769630167 cites W2585964747 @default.
- W2769630167 cites W3031793683 @default.
- W2769630167 doi "https://doi.org/10.1007/s00213-017-4794-3" @default.
- W2769630167 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5823729" @default.
- W2769630167 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29181816" @default.
- W2769630167 hasPublicationYear "2017" @default.
- W2769630167 type Work @default.