FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2769684125> ?p ?o ?g. }

• W2769684125 endingPage "1827" @default.
• W2769684125 startingPage "1813" @default.
• W2769684125 abstract "Bacterial translocation and lipopolysaccharide (LPS) leakage occur at a very early stage of liver fibrosis in animal models. We studied the role of LPS in hepatic stellate cell (HSC) activation and the underlying mechanisms in vitro and in vivo. Herein, we demonstrated that LPS treatment led to a dramatic increase in autophagosome formation and autophagic flux in LX-2 cells and HSCs, which was mediated through the AKT-MTOR and AMPK-ULK1 pathway. LPS significantly decreased the lipid content, including the lipid droplet (LD) number and lipid staining area in HSCs; pretreatment with macroautophagy/autophagy inhibitors or silencing ATG5 attenuated this decrease. Furthermore, lipophagy was induced by LPS through the autophagy-lysosomal pathway in LX-2 cells and HSCs. Additionally, LPS-induced autophagy further reduced retinoic acid (RA) signaling, as demonstrated by a decrease in the intracellular RA level and Rar target genes, resulting in the downregulation of Bambi and promoting the sensitization of the HSC's fibrosis response to TGFB. Compared with CCl4 injection alone, CCl4 plus LPS injection exaggerated liver fibrosis in mice, as demonstrated by increased Col1a1 (collagen, type I, α 1), Acta2, Tgfb and Timp1 mRNA expression, ACTA2/α-SMA and COL1A1 protein expression, and Sirius Red staining area, which could be attenuated by injection of an autophagy inhibitor. LPS also reduced lipid content in HSCs in vivo, with this change being attenuated by chloroquine (CQ) administration. In conclusion, LPS-induced autophagy resulted in LD loss, RA signaling dysfunction, and downregulation of the TGFB pseudoreceptor Bambi, thus sensitizing HSCs to TGFB signaling." @default.
• W2769684125 created "2017-12-04" @default.
• W2769684125 creator A5006668600 @default.
• W2769684125 creator A5065482772 @default.
• W2769684125 creator A5081716701 @default.
• W2769684125 creator A5084685500 @default.
• W2769684125 date "2017-11-02" @default.
• W2769684125 modified "2023-10-16" @default.
• W2769684125 title "Lipopolysaccharide mediates hepatic stellate cell activation by regulating autophagy and retinoic acid signaling" @default.
• W2769684125 cites W1523693806 @default.
• W2769684125 cites W1534985842 @default.
• W2769684125 cites W1807334039 @default.
• W2769684125 cites W1811253366 @default.
• W2769684125 cites W1903133626 @default.
• W2769684125 cites W1929999284 @default.
• W2769684125 cites W1970637701 @default.
• W2769684125 cites W1988327539 @default.
• W2769684125 cites W1993437989 @default.
• W2769684125 cites W1995212212 @default.
• W2769684125 cites W1996980381 @default.
• W2769684125 cites W2002733746 @default.
• W2769684125 cites W2003289032 @default.
• W2769684125 cites W2005270729 @default.
• W2769684125 cites W2006215820 @default.
• W2769684125 cites W2007505836 @default.
• W2769684125 cites W2020425332 @default.
• W2769684125 cites W2023525475 @default.
• W2769684125 cites W2025458328 @default.
• W2769684125 cites W2025665129 @default.
• W2769684125 cites W2036464358 @default.
• W2769684125 cites W2037108200 @default.
• W2769684125 cites W2041911908 @default.
• W2769684125 cites W2048030072 @default.
• W2769684125 cites W2053670812 @default.
• W2769684125 cites W2055112613 @default.
• W2769684125 cites W2056847885 @default.
• W2769684125 cites W2058197170 @default.
• W2769684125 cites W2069457144 @default.
• W2769684125 cites W2076683315 @default.
• W2769684125 cites W2078194501 @default.
• W2769684125 cites W2080070085 @default.
• W2769684125 cites W2089117732 @default.
• W2769684125 cites W2102164563 @default.
• W2769684125 cites W2107036592 @default.
• W2769684125 cites W2109034822 @default.
• W2769684125 cites W2123782685 @default.
• W2769684125 cites W2126957535 @default.
• W2769684125 cites W2132249975 @default.
• W2769684125 cites W2140259969 @default.
• W2769684125 cites W2142931701 @default.
• W2769684125 cites W2145019698 @default.
• W2769684125 cites W2153223490 @default.
• W2769684125 cites W2155259249 @default.
• W2769684125 cites W2158129157 @default.
• W2769684125 cites W2162155294 @default.
• W2769684125 cites W2164906049 @default.
• W2769684125 cites W2510379466 @default.
• W2769684125 cites W2602035017 @default.
• W2769684125 cites W4255712601 @default.
• W2769684125 doi "https://doi.org/10.1080/15548627.2017.1356550" @default.
• W2769684125 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5788469" @default.
• W2769684125 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29160747" @default.
• W2769684125 hasPublicationYear "2017" @default.
• W2769684125 type Work @default.
• W2769684125 sameAs 2769684125 @default.
• W2769684125 citedByCount "75" @default.
• W2769684125 countsByYear W27696841252018 @default.
• W2769684125 countsByYear W27696841252019 @default.
• W2769684125 countsByYear W27696841252020 @default.
• W2769684125 countsByYear W27696841252021 @default.
• W2769684125 countsByYear W27696841252022 @default.
• W2769684125 countsByYear W27696841252023 @default.
• W2769684125 crossrefType "journal-article" @default.
• W2769684125 hasAuthorship W2769684125A5006668600 @default.
• W2769684125 hasAuthorship W2769684125A5065482772 @default.
• W2769684125 hasAuthorship W2769684125A5081716701 @default.
• W2769684125 hasAuthorship W2769684125A5084685500 @default.
• W2769684125 hasBestOaLocation W27696841251 @default.
• W2769684125 hasConcept C104317684 @default.
• W2769684125 hasConcept C122927707 @default.
• W2769684125 hasConcept C126322002 @default.
• W2769684125 hasConcept C127561419 @default.
• W2769684125 hasConcept C134018914 @default.
• W2769684125 hasConcept C176891718 @default.
• W2769684125 hasConcept C184235292 @default.
• W2769684125 hasConcept C190283241 @default.
• W2769684125 hasConcept C198826908 @default.
• W2769684125 hasConcept C203014093 @default.
• W2769684125 hasConcept C203522944 @default.
• W2769684125 hasConcept C204232928 @default.
• W2769684125 hasConcept C25095133 @default.
• W2769684125 hasConcept C2779770810 @default.
• W2769684125 hasConcept C2780124434 @default.
• W2769684125 hasConcept C2780559512 @default.
• W2769684125 hasConcept C2780806160 @default.
• W2769684125 hasConcept C2781000418 @default.
• W2769684125 hasConcept C2993667909 @default.
• W2769684125 hasConcept C502942594 @default.

• next