FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2769740094> ?p ?o ?g. }

• W2769740094 abstract "Background: Toll-like receptors (TLRs) mediate recognition of Helicobacter pylori and initiate the innate immune response to infection. Toll-like receptors polymorphisms are thought to influence susceptibility to H. pylori infection and H. pylori-related diseases. Objectives: To investigate the association of TLR polymorphisms with the susceptibility to H. pylori infection and various types of gastritis in Thai patients. Methods: The single nucleotide polymorphisms (SNPs) TLR1 rs4833095, TLR2 rs3804099 and rs3804100, TLR4 rs10759932 and TLR10 rs10004195 were analysed in 400 gastritis patients by real-time PCR using a TaqMan SNP Genotyping Assay. The association between TLR polymorphisms and the risk of H. pylori infection was investigated in 196 uninfected and 204 H. pylori-infected patients. The associations between TLR genotypes and the risk of gastric pathology changes, including chronic gastritis (N = 312 cases) and precancerous gastric lesions/gastric cancer (GC) (N = 88 cases), were examined. Univariate analysis was used to determine odds ratios (ORs) with confidence intervals (95% CIs). Results: Patients with the CC -or TT homozygous genotype for TLR1 rs4833095 had a significantly increased risk of H. pylori susceptibility (OR = 2.28, 95% CI = 1.27 - 7.60, P = 0.02 and OR = 1.34, 95% CI = 0.97 - 1.86, P = 0.04, respectively). Patients with the AA homozygous genotype for TLR10 rs10004195 had a significantly increased risk of H. pylori susceptibility (OR = 1.28, 95% CI = 0.98 - 1.76, P = 0.01) and exhibited a significantly increased risk of precancerous gastric lesions/GC (OR = 8.75, 95% CI = 2.78 - 14.24, P < 0.01). Conclusions: Our findings suggest that the TLR1 rs4833095 and TLR10 rs10004195 polymorphisms are potential genetic risk factors that modify the H. pylori infection susceptibility and influence the clinical manifestation of chronic gastritis, precancerous gastric lesions and GC in Thai patients." @default.
• W2769740094 created "2017-12-04" @default.
• W2769740094 creator A5021821092 @default.
• W2769740094 creator A5050109597 @default.
• W2769740094 creator A5058813743 @default.
• W2769740094 date "2017-11-26" @default.
• W2769740094 modified "2023-10-01" @default.
• W2769740094 title "Toll-Like Receptors are Associated with Helicobacter pylori Infection and Gastric Mucosa Pathology" @default.
• W2769740094 cites W1508952387 @default.
• W2769740094 cites W1520365933 @default.
• W2769740094 cites W1541516662 @default.
• W2769740094 cites W1835848353 @default.
• W2769740094 cites W1967918248 @default.
• W2769740094 cites W1975178331 @default.
• W2769740094 cites W1983902684 @default.
• W2769740094 cites W1999381834 @default.
• W2769740094 cites W2007774666 @default.
• W2769740094 cites W2008797060 @default.
• W2769740094 cites W2012301659 @default.
• W2769740094 cites W2036990065 @default.
• W2769740094 cites W2043003819 @default.
• W2769740094 cites W2049246329 @default.
• W2769740094 cites W2061342566 @default.
• W2769740094 cites W2069378448 @default.
• W2769740094 cites W2075348787 @default.
• W2769740094 cites W2091229884 @default.
• W2769740094 cites W2100000977 @default.
• W2769740094 cites W2129783761 @default.
• W2769740094 cites W2135443167 @default.
• W2769740094 cites W2142059693 @default.
• W2769740094 cites W2148340490 @default.
• W2769740094 cites W2153354382 @default.
• W2769740094 cites W2153754546 @default.
• W2769740094 cites W2175687902 @default.
• W2769740094 cites W2182497060 @default.
• W2769740094 cites W2209788253 @default.
• W2769740094 cites W2319773610 @default.
• W2769740094 cites W2346085274 @default.
• W2769740094 cites W2564996630 @default.
• W2769740094 cites W2603382970 @default.
• W2769740094 cites W2725028867 @default.
• W2769740094 doi "https://doi.org/10.5812/jjm.58351" @default.
• W2769740094 hasPublicationYear "2017" @default.
• W2769740094 type Work @default.
• W2769740094 sameAs 2769740094 @default.
• W2769740094 citedByCount "2" @default.
• W2769740094 countsByYear W27697400942020 @default.
• W2769740094 countsByYear W27697400942021 @default.
• W2769740094 crossrefType "journal-article" @default.
• W2769740094 hasAuthorship W2769740094A5021821092 @default.
• W2769740094 hasAuthorship W2769740094A5050109597 @default.
• W2769740094 hasAuthorship W2769740094A5058813743 @default.
• W2769740094 hasBestOaLocation W27697400941 @default.
• W2769740094 hasConcept C104317684 @default.
• W2769740094 hasConcept C126322002 @default.
• W2769740094 hasConcept C135763542 @default.
• W2769740094 hasConcept C153209595 @default.
• W2769740094 hasConcept C156957248 @default.
• W2769740094 hasConcept C170493617 @default.
• W2769740094 hasConcept C203014093 @default.
• W2769740094 hasConcept C2776070231 @default.
• W2769740094 hasConcept C2776409635 @default.
• W2769740094 hasConcept C2778677798 @default.
• W2769740094 hasConcept C2780561475 @default.
• W2769740094 hasConcept C2781236682 @default.
• W2769740094 hasConcept C31467283 @default.
• W2769740094 hasConcept C54355233 @default.
• W2769740094 hasConcept C71924100 @default.
• W2769740094 hasConcept C86803240 @default.
• W2769740094 hasConcept C90924648 @default.
• W2769740094 hasConceptScore W2769740094C104317684 @default.
• W2769740094 hasConceptScore W2769740094C126322002 @default.
• W2769740094 hasConceptScore W2769740094C135763542 @default.
• W2769740094 hasConceptScore W2769740094C153209595 @default.
• W2769740094 hasConceptScore W2769740094C156957248 @default.
• W2769740094 hasConceptScore W2769740094C170493617 @default.
• W2769740094 hasConceptScore W2769740094C203014093 @default.
• W2769740094 hasConceptScore W2769740094C2776070231 @default.
• W2769740094 hasConceptScore W2769740094C2776409635 @default.
• W2769740094 hasConceptScore W2769740094C2778677798 @default.
• W2769740094 hasConceptScore W2769740094C2780561475 @default.
• W2769740094 hasConceptScore W2769740094C2781236682 @default.
• W2769740094 hasConceptScore W2769740094C31467283 @default.
• W2769740094 hasConceptScore W2769740094C54355233 @default.
• W2769740094 hasConceptScore W2769740094C71924100 @default.
• W2769740094 hasConceptScore W2769740094C86803240 @default.
• W2769740094 hasConceptScore W2769740094C90924648 @default.
• W2769740094 hasIssue "12" @default.
• W2769740094 hasLocation W27697400941 @default.
• W2769740094 hasOpenAccess W2769740094 @default.
• W2769740094 hasPrimaryLocation W27697400941 @default.
• W2769740094 hasRelatedWork W1984793389 @default.
• W2769740094 hasRelatedWork W2368149926 @default.
• W2769740094 hasRelatedWork W2372870648 @default.
• W2769740094 hasRelatedWork W2379237289 @default.
• W2769740094 hasRelatedWork W2381712605 @default.
• W2769740094 hasRelatedWork W2409408395 @default.
• W2769740094 hasRelatedWork W2411616076 @default.
• W2769740094 hasRelatedWork W2440813856 @default.
• W2769740094 hasRelatedWork W2551242284 @default.

• next