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- W2769759136 abstract "Voltage-gated sodium (Na+) channels are expressed in virtually all electrically excitable tissues and are essential for muscle contraction and the conduction of impulses within the peripheral and central nervous systems. Genetic disorders that disrupt the function of these channels produce an array of Na+ channelopathies resulting in neuronal impairment, chronic pain, neuromuscular pathologies, and cardiac arrhythmias. Because of their importance to the conduction of electrical signals, Na+ channels are the target of a wide variety of local anesthetic, antiarrhythmic, anticonvulsant, and antidepressant drugs. The voltage-gated family of Na+ channels is composed of α-subunits that encode for the voltage sensor domains and the Na+-selective permeation pore. In vivo, Na+ channel α-subunits are associated with one or more accessory β-subunits (β1–β4) that regulate gating properties, trafficking, and cell-surface expression of the channels. The permeation pore of Na+ channels is divided in two parts: the outer mouth of the pore is the site of the ion selectivity filter, while the inner cytoplasmic pore serves as the channel activation gate. The cytoplasmic lining of the permeation pore is formed by the S6 segments that include highly conserved aromatic amino acids important for drug binding. These residues are believed to undergo voltage-dependent conformational changes that alter drug binding as the channels cycle through the closed, open, and inactivated states. The purpose of this chapter is to broadly review the mechanisms of Na+ channel gating and the models used to describe drug binding and Na+ channel inhibition." @default.
- W2769759136 created "2017-12-04" @default.
- W2769759136 creator A5005534121 @default.
- W2769759136 creator A5016356391 @default.
- W2769759136 date "2017-01-01" @default.
- W2769759136 modified "2023-09-25" @default.
- W2769759136 title "Mechanisms of Drug Binding to Voltage-Gated Sodium Channels" @default.
- W2769759136 cites W1517714742 @default.
- W2769759136 cites W1517918086 @default.
- W2769759136 cites W1583392605 @default.
- W2769759136 cites W1604355805 @default.
- W2769759136 cites W1606667854 @default.
- W2769759136 cites W1874317695 @default.
- W2769759136 cites W1937176890 @default.
- W2769759136 cites W1967166972 @default.
- W2769759136 cites W1968612372 @default.
- W2769759136 cites W1968903551 @default.
- W2769759136 cites W1968924035 @default.
- W2769759136 cites W1969577194 @default.
- W2769759136 cites W1971459402 @default.
- W2769759136 cites W1973064936 @default.
- W2769759136 cites W1973420297 @default.
- W2769759136 cites W1974411391 @default.
- W2769759136 cites W1974425336 @default.
- W2769759136 cites W1983187084 @default.
- W2769759136 cites W1988669735 @default.
- W2769759136 cites W1993584057 @default.
- W2769759136 cites W1996437700 @default.
- W2769759136 cites W1998491922 @default.
- W2769759136 cites W2001063072 @default.
- W2769759136 cites W2003735230 @default.
- W2769759136 cites W2006090981 @default.
- W2769759136 cites W2009518885 @default.
- W2769759136 cites W2012081623 @default.
- W2769759136 cites W2012350838 @default.
- W2769759136 cites W2013666247 @default.
- W2769759136 cites W2014953544 @default.
- W2769759136 cites W2016068689 @default.
- W2769759136 cites W2017312700 @default.
- W2769759136 cites W2017757683 @default.
- W2769759136 cites W2022614248 @default.
- W2769759136 cites W2024012135 @default.
- W2769759136 cites W2028982558 @default.
- W2769759136 cites W2030948251 @default.
- W2769759136 cites W2032077935 @default.
- W2769759136 cites W2036295857 @default.
- W2769759136 cites W2042147650 @default.
- W2769759136 cites W2045139512 @default.
- W2769759136 cites W2047648703 @default.
- W2769759136 cites W2047711606 @default.
- W2769759136 cites W2047725441 @default.
- W2769759136 cites W2052034938 @default.
- W2769759136 cites W2053376101 @default.
- W2769759136 cites W2054058473 @default.
- W2769759136 cites W2054336104 @default.
- W2769759136 cites W2055983112 @default.
- W2769759136 cites W2057610250 @default.
- W2769759136 cites W2057925083 @default.
- W2769759136 cites W2059229640 @default.
- W2769759136 cites W2063906343 @default.
- W2769759136 cites W2064649005 @default.
- W2769759136 cites W2065476766 @default.
- W2769759136 cites W2065857917 @default.
- W2769759136 cites W2067794161 @default.
- W2769759136 cites W2070233250 @default.
- W2769759136 cites W2070676751 @default.
- W2769759136 cites W2072749656 @default.
- W2769759136 cites W2073929496 @default.
- W2769759136 cites W2075075961 @default.
- W2769759136 cites W2075824960 @default.
- W2769759136 cites W2075977700 @default.
- W2769759136 cites W2076378327 @default.
- W2769759136 cites W2078840491 @default.
- W2769759136 cites W2080082506 @default.
- W2769759136 cites W2081030337 @default.
- W2769759136 cites W2081366384 @default.
- W2769759136 cites W2084018660 @default.
- W2769759136 cites W2084163751 @default.
- W2769759136 cites W2084670381 @default.
- W2769759136 cites W2085873341 @default.
- W2769759136 cites W2087122819 @default.
- W2769759136 cites W2087424870 @default.
- W2769759136 cites W2093297294 @default.
- W2769759136 cites W2094193659 @default.
- W2769759136 cites W2094677101 @default.
- W2769759136 cites W2097308354 @default.
- W2769759136 cites W2099204185 @default.
- W2769759136 cites W2099487337 @default.
- W2769759136 cites W2101299936 @default.
- W2769759136 cites W2103479374 @default.
- W2769759136 cites W2104415321 @default.
- W2769759136 cites W2104835101 @default.
- W2769759136 cites W2105403855 @default.
- W2769759136 cites W2106207499 @default.
- W2769759136 cites W2107958165 @default.
- W2769759136 cites W2108793171 @default.
- W2769759136 cites W2112846165 @default.
- W2769759136 cites W2115052737 @default.