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• W2769771129 abstract "Abstract The retrotrapezoid nucleus (RTN) regulates breathing in a CO 2 ‐ and state‐dependent manner. RTN neurons are glutamatergic and innervate principally the respiratory pattern generator; they regulate multiple aspects of breathing, including active expiration, and maintain breathing automaticity during non‐REM sleep. RTN neurons encode arterial /pH via cell‐autonomous and paracrine mechanisms, and via input from other CO 2 ‐responsive neurons. In short, RTN neurons are a pivotal structure for breathing automaticity and arterial homeostasis. The carotid bodies stimulate the respiratory pattern generator directly and indirectly by activating RTN via a neuronal projection originating within the solitary tract nucleus. The indirect pathway operates under normo‐ or hypercapnic conditions; under respiratory alkalosis (e.g. hypoxia) RTN neurons are silent and the excitatory input from the carotid bodies is suppressed. Also, silencing RTN neurons optogenetically quickly triggers a compensatory increase in carotid body activity. Thus, in conscious mammals, breathing is subject to a dual and interdependent feedback regulation by chemoreceptors. Depending on the circumstance, the activity of the carotid bodies and that of RTN vary in the same or the opposite directions, producing additive or countervailing effects on breathing. These interactions are mediated either via changes in blood gases or by brainstem neuronal connections, but their ultimate effect is invariably to minimize arterial fluctuations. We discuss the potential relevance of this dual chemoreceptor feedback to cardiorespiratory abnormalities present in diseases in which the carotid bodies are hyperactive at rest, e.g. essential hypertension, obstructive sleep apnoea and heart failure. image" @default.
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• W2769771129 date "2017-12-27" @default.
• W2769771129 modified "2023-10-16" @default.
• W2769771129 title "Interdependent feedback regulation of breathing by the carotid bodies and the retrotrapezoid nucleus" @default.
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• W2769771129 doi "https://doi.org/10.1113/jp274357" @default.
• W2769771129 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6068251" @default.
• W2769771129 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29168167" @default.
• W2769771129 hasPublicationYear "2017" @default.
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