FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2769798072> ?p ?o ?g. }

• W2769798072 endingPage "103" @default.
• W2769798072 startingPage "97" @default.
• W2769798072 abstract "Molecular testing with the Thyroseq v2 next generation sequencing panel (Thyroseq) is used to estimate the risk of cancer in indeterminate thyroid nodules.We analyzed 156 indeterminate thyroid nodules evaluated with Thyroseq, across 3 institutions. Thyroseq data and surgical pathology were matched via pathologic re-review. A result was considered Thyroseq positive if molecular alterations were annotated on the report with malignancy probability >30%. Performance characteristics were estimated using Bayes theorem.The Thyroseq-negative call rate was 65% (102/156). On surgical pathology, 16% (10/63) of nodules were malignant. The positive predictive value of a Thyroseq-positive result was 22% (8/37; if 2 noninvasive follicular thyroid neoplasm with papillary-like nuclear features are counted as malignant, 27%, 10/37). There was 1 false-negative result (negative predictive value 96%, 22/23). The most common mutation was NRAS (19/37) with a positive predictive value of 7% (1/15). The positive predictive value of all RAS mutations (HRAS, KRAS, NRAS) was 9% (2/22). The second most common mutation, BRAF V600E, had positive predictive value of 100% (3/3).We report an external analysis of Thyroseq performance in the evaluation of indeterminate thyroid nodules. These data indicate that Thyroseq is likely to offer high negative predictive value but low positive predictive value. Many genetic alterations appear to be nonspecific for malignancy, and positive results should be interpreted with caution. These findings have implications for the management of indeterminate thyroid nodules profiled with Thyroseq." @default.
• W2769798072 created "2017-12-04" @default.
• W2769798072 creator A5000138812 @default.
• W2769798072 creator A5012795067 @default.
• W2769798072 creator A5032419866 @default.
• W2769798072 creator A5037770761 @default.
• W2769798072 creator A5038513493 @default.
• W2769798072 creator A5061669299 @default.
• W2769798072 creator A5084915000 @default.
• W2769798072 creator A5085315196 @default.
• W2769798072 date "2018-01-01" @default.
• W2769798072 modified "2023-10-02" @default.
• W2769798072 title "Clinical performance of a next-generation sequencing assay (ThyroSeq v2) in the evaluation of indeterminate thyroid nodules" @default.
• W2769798072 cites W1484128005 @default.
• W2769798072 cites W1495498498 @default.
• W2769798072 cites W1574818579 @default.
• W2769798072 cites W1967663155 @default.
• W2769798072 cites W1978461235 @default.
• W2769798072 cites W2005890649 @default.
• W2769798072 cites W2024802664 @default.
• W2769798072 cites W2030459046 @default.
• W2769798072 cites W2033882181 @default.
• W2769798072 cites W2039496939 @default.
• W2769798072 cites W2065059141 @default.
• W2769798072 cites W2077963729 @default.
• W2769798072 cites W2103912638 @default.
• W2769798072 cites W2109174925 @default.
• W2769798072 cites W2112308637 @default.
• W2769798072 cites W2145150141 @default.
• W2769798072 cites W2152446218 @default.
• W2769798072 cites W2337882641 @default.
• W2769798072 cites W2495917624 @default.
• W2769798072 cites W2553638316 @default.
• W2769798072 cites W2564067229 @default.
• W2769798072 cites W3021493465 @default.
• W2769798072 doi "https://doi.org/10.1016/j.surg.2017.07.032" @default.
• W2769798072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29154079" @default.
• W2769798072 hasPublicationYear "2018" @default.
• W2769798072 type Work @default.
• W2769798072 sameAs 2769798072 @default.
• W2769798072 citedByCount "48" @default.
• W2769798072 countsByYear W27697980722018 @default.
• W2769798072 countsByYear W27697980722019 @default.
• W2769798072 countsByYear W27697980722020 @default.
• W2769798072 countsByYear W27697980722021 @default.
• W2769798072 countsByYear W27697980722022 @default.
• W2769798072 countsByYear W27697980722023 @default.
• W2769798072 crossrefType "journal-article" @default.
• W2769798072 hasAuthorship W2769798072A5000138812 @default.
• W2769798072 hasAuthorship W2769798072A5012795067 @default.
• W2769798072 hasAuthorship W2769798072A5032419866 @default.
• W2769798072 hasAuthorship W2769798072A5037770761 @default.
• W2769798072 hasAuthorship W2769798072A5038513493 @default.
• W2769798072 hasAuthorship W2769798072A5061669299 @default.
• W2769798072 hasAuthorship W2769798072A5084915000 @default.
• W2769798072 hasAuthorship W2769798072A5085315196 @default.
• W2769798072 hasConcept C1167327 @default.
• W2769798072 hasConcept C121608353 @default.
• W2769798072 hasConcept C126322002 @default.
• W2769798072 hasConcept C126838900 @default.
• W2769798072 hasConcept C142724271 @default.
• W2769798072 hasConcept C198433322 @default.
• W2769798072 hasConcept C202444582 @default.
• W2769798072 hasConcept C21790070 @default.
• W2769798072 hasConcept C2779022025 @default.
• W2769798072 hasConcept C2779399171 @default.
• W2769798072 hasConcept C2779761222 @default.
• W2769798072 hasConcept C2781187634 @default.
• W2769798072 hasConcept C3019719930 @default.
• W2769798072 hasConcept C33923547 @default.
• W2769798072 hasConcept C526584372 @default.
• W2769798072 hasConcept C526805850 @default.
• W2769798072 hasConcept C71924100 @default.
• W2769798072 hasConcept C94624232 @default.
• W2769798072 hasConceptScore W2769798072C1167327 @default.
• W2769798072 hasConceptScore W2769798072C121608353 @default.
• W2769798072 hasConceptScore W2769798072C126322002 @default.
• W2769798072 hasConceptScore W2769798072C126838900 @default.
• W2769798072 hasConceptScore W2769798072C142724271 @default.
• W2769798072 hasConceptScore W2769798072C198433322 @default.
• W2769798072 hasConceptScore W2769798072C202444582 @default.
• W2769798072 hasConceptScore W2769798072C21790070 @default.
• W2769798072 hasConceptScore W2769798072C2779022025 @default.
• W2769798072 hasConceptScore W2769798072C2779399171 @default.
• W2769798072 hasConceptScore W2769798072C2779761222 @default.
• W2769798072 hasConceptScore W2769798072C2781187634 @default.
• W2769798072 hasConceptScore W2769798072C3019719930 @default.
• W2769798072 hasConceptScore W2769798072C33923547 @default.
• W2769798072 hasConceptScore W2769798072C526584372 @default.
• W2769798072 hasConceptScore W2769798072C526805850 @default.
• W2769798072 hasConceptScore W2769798072C71924100 @default.
• W2769798072 hasConceptScore W2769798072C94624232 @default.
• W2769798072 hasIssue "1" @default.
• W2769798072 hasLocation W27697980721 @default.
• W2769798072 hasLocation W27697980722 @default.
• W2769798072 hasOpenAccess W2769798072 @default.
• W2769798072 hasPrimaryLocation W27697980721 @default.
• W2769798072 hasRelatedWork W1977599031 @default.

• next