FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2769854578> ?p ?o ?g. }

• W2769854578 endingPage "3019" @default.
• W2769854578 startingPage "3010" @default.
• W2769854578 abstract "We previously developed optimized DNA vaccines against both Lassa fever and Ebola hemorrhagic fever viruses and demonstrated that they were protective individually in guinea pig and nonhuman primate models. In this study, we vaccinated groups of strain 13 guinea pigs two times, four weeks apart with 50 µg of each DNA vaccine or a mock vaccine at discrete sites by intradermal electroporation. Five weeks following the second vaccinations, guinea pigs were exposed to lethal doses of Lassa virus, Ebola virus, or a combination of both viruses simultaneously. None of the vaccinated guinea pigs, regardless of challenge virus and including the coinfected group, displayed weight loss, fever or other disease signs, and all survived to the study endpoint. All of the mock-vaccinated guinea pigs that were infected with Lassa virus, and all but one of the EBOV-infected mock-vaccinated guinea pigs succumbed. In order to determine if the dual-agent vaccination strategy could protect against both viruses if exposures were temporally separated, we held the surviving vaccinates in BSL-4 for approximately 120 days to perform a cross-challenge experiment in which guinea pigs originally infected with Lassa virus received a lethal dose of Ebola virus and those originally infected with Ebola virus were infected with a lethal dose of Lassa virus. All guinea pigs remained healthy and survived to the study endpoint. This study clearly demonstrates that DNA vaccines against Lassa and Ebola viruses can elicit protective immunity against both individual virus exposures as well as in a mixed-infection environment." @default.
• W2769854578 created "2017-12-04" @default.
• W2769854578 creator A5004585142 @default.
• W2769854578 creator A5009079044 @default.
• W2769854578 creator A5022884834 @default.
• W2769854578 creator A5028996561 @default.
• W2769854578 creator A5062840115 @default.
• W2769854578 creator A5064715411 @default.
• W2769854578 creator A5068072442 @default.
• W2769854578 creator A5075535603 @default.
• W2769854578 creator A5091480020 @default.
• W2769854578 date "2017-11-14" @default.
• W2769854578 modified "2023-10-16" @default.
• W2769854578 title "DNA vaccines elicit durable protective immunity against individual or simultaneous infections with Lassa and Ebola viruses in guinea pigs" @default.
• W2769854578 cites W1480599355 @default.
• W2769854578 cites W1596809034 @default.
• W2769854578 cites W1759518163 @default.
• W2769854578 cites W2000541283 @default.
• W2769854578 cites W2011356365 @default.
• W2769854578 cites W2022953507 @default.
• W2769854578 cites W2028649908 @default.
• W2769854578 cites W2035572149 @default.
• W2769854578 cites W2039546121 @default.
• W2769854578 cites W2040283003 @default.
• W2769854578 cites W2065386815 @default.
• W2769854578 cites W2103952224 @default.
• W2769854578 cites W2107446952 @default.
• W2769854578 cites W2115102869 @default.
• W2769854578 cites W2150174614 @default.
• W2769854578 cites W2154652945 @default.
• W2769854578 cites W2161081629 @default.
• W2769854578 cites W2396210930 @default.
• W2769854578 cites W2401469828 @default.
• W2769854578 cites W2607521239 @default.
• W2769854578 doi "https://doi.org/10.1080/21645515.2017.1382780" @default.
• W2769854578 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5718824" @default.
• W2769854578 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29135337" @default.
• W2769854578 hasPublicationYear "2017" @default.
• W2769854578 type Work @default.
• W2769854578 sameAs 2769854578 @default.
• W2769854578 citedByCount "16" @default.
• W2769854578 countsByYear W27698545782018 @default.
• W2769854578 countsByYear W27698545782019 @default.
• W2769854578 countsByYear W27698545782020 @default.
• W2769854578 countsByYear W27698545782021 @default.
• W2769854578 countsByYear W27698545782022 @default.
• W2769854578 countsByYear W27698545782023 @default.
• W2769854578 crossrefType "journal-article" @default.
• W2769854578 hasAuthorship W2769854578A5004585142 @default.
• W2769854578 hasAuthorship W2769854578A5009079044 @default.
• W2769854578 hasAuthorship W2769854578A5022884834 @default.
• W2769854578 hasAuthorship W2769854578A5028996561 @default.
• W2769854578 hasAuthorship W2769854578A5062840115 @default.
• W2769854578 hasAuthorship W2769854578A5064715411 @default.
• W2769854578 hasAuthorship W2769854578A5068072442 @default.
• W2769854578 hasAuthorship W2769854578A5075535603 @default.
• W2769854578 hasAuthorship W2769854578A5091480020 @default.
• W2769854578 hasBestOaLocation W27698545781 @default.
• W2769854578 hasConcept C134018914 @default.
• W2769854578 hasConcept C159047783 @default.
• W2769854578 hasConcept C167508917 @default.
• W2769854578 hasConcept C167672396 @default.
• W2769854578 hasConcept C203014093 @default.
• W2769854578 hasConcept C22070199 @default.
• W2769854578 hasConcept C2522874641 @default.
• W2769854578 hasConcept C2777427142 @default.
• W2769854578 hasConcept C2777469322 @default.
• W2769854578 hasConcept C2778548629 @default.
• W2769854578 hasConcept C2778815084 @default.
• W2769854578 hasConcept C2779341262 @default.
• W2769854578 hasConcept C2779574689 @default.
• W2769854578 hasConcept C2780023225 @default.
• W2769854578 hasConcept C2780190958 @default.
• W2769854578 hasConcept C2780801004 @default.
• W2769854578 hasConcept C71924100 @default.
• W2769854578 hasConcept C86803240 @default.
• W2769854578 hasConcept C8891405 @default.
• W2769854578 hasConceptScore W2769854578C134018914 @default.
• W2769854578 hasConceptScore W2769854578C159047783 @default.
• W2769854578 hasConceptScore W2769854578C167508917 @default.
• W2769854578 hasConceptScore W2769854578C167672396 @default.
• W2769854578 hasConceptScore W2769854578C203014093 @default.
• W2769854578 hasConceptScore W2769854578C22070199 @default.
• W2769854578 hasConceptScore W2769854578C2522874641 @default.
• W2769854578 hasConceptScore W2769854578C2777427142 @default.
• W2769854578 hasConceptScore W2769854578C2777469322 @default.
• W2769854578 hasConceptScore W2769854578C2778548629 @default.
• W2769854578 hasConceptScore W2769854578C2778815084 @default.
• W2769854578 hasConceptScore W2769854578C2779341262 @default.
• W2769854578 hasConceptScore W2769854578C2779574689 @default.
• W2769854578 hasConceptScore W2769854578C2780023225 @default.
• W2769854578 hasConceptScore W2769854578C2780190958 @default.
• W2769854578 hasConceptScore W2769854578C2780801004 @default.
• W2769854578 hasConceptScore W2769854578C71924100 @default.
• W2769854578 hasConceptScore W2769854578C86803240 @default.
• W2769854578 hasConceptScore W2769854578C8891405 @default.
• W2769854578 hasIssue "12" @default.
• W2769854578 hasLocation W27698545781 @default.

• next