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- W2769866734 endingPage "153" @default.
- W2769866734 startingPage "142" @default.
- W2769866734 abstract "The focus of this review is to provide a synthesis of the current literature on the role of brain choline, as measured by proton magnetic resonance spectroscopy (1H-MRS), in major depressive disorder (MDD). The most recent 1H-MRS literature review took place over 10 years ago and, reflecting the high level of research on this topic, much has been learned since then. Higher brain choline levels have been linked to an increase in depression, and a cholinergic model for MDD development has been postulated. However, current 1H-MRS studies have been inconclusive regarding the role of choline in depression. Data from eighty-six peer-reviewed studies were analyzed for a random-effects model meta-analysis. Two significant findings are reported. Papers that did not report segmentation had a significant, moderate effect size. Higher choline concentrations in the frontal lobe were found in depressed patients, both in those who responded to treatment and those who did not, after treatment with psychiatric medication, repetitive transcranial magnetic stimulation, or electroconvulsive therapy. Findings from this review may add to existing information regarding the role of brain choline in MDD. This may provide a future target for treatment and drug development. It also may serve as a biomarker for treatment progress." @default.
- W2769866734 created "2017-12-04" @default.
- W2769866734 creator A5006809096 @default.
- W2769866734 creator A5057767291 @default.
- W2769866734 date "2018-01-01" @default.
- W2769866734 modified "2023-10-18" @default.
- W2769866734 title "Brain choline in major depression: A review of the literature" @default.
- W2769866734 cites W1585601802 @default.
- W2769866734 cites W1964605289 @default.
- W2769866734 cites W1965844304 @default.
- W2769866734 cites W1970224865 @default.
- W2769866734 cites W1975429277 @default.
- W2769866734 cites W1979454114 @default.
- W2769866734 cites W1980344179 @default.
- W2769866734 cites W1982114694 @default.
- W2769866734 cites W1983292916 @default.
- W2769866734 cites W1984324920 @default.
- W2769866734 cites W1999952623 @default.
- W2769866734 cites W2002375162 @default.
- W2769866734 cites W2003119200 @default.
- W2769866734 cites W2004272594 @default.
- W2769866734 cites W2006546769 @default.
- W2769866734 cites W2008630639 @default.
- W2769866734 cites W2010302023 @default.
- W2769866734 cites W2012502638 @default.
- W2769866734 cites W2015618763 @default.
- W2769866734 cites W2016681170 @default.
- W2769866734 cites W2018527646 @default.
- W2769866734 cites W2020473668 @default.
- W2769866734 cites W2022328515 @default.
- W2769866734 cites W2023988337 @default.
- W2769866734 cites W2025582053 @default.
- W2769866734 cites W2025655482 @default.
- W2769866734 cites W2028858660 @default.
- W2769866734 cites W2033352712 @default.
- W2769866734 cites W2037557484 @default.
- W2769866734 cites W2037981600 @default.
- W2769866734 cites W2039754622 @default.
- W2769866734 cites W2039976073 @default.
- W2769866734 cites W2040510196 @default.
- W2769866734 cites W2041247688 @default.
- W2769866734 cites W2043317589 @default.
- W2769866734 cites W2043323573 @default.
- W2769866734 cites W2047801483 @default.
- W2769866734 cites W2048642366 @default.
- W2769866734 cites W2051945563 @default.
- W2769866734 cites W2056272943 @default.
- W2769866734 cites W2063194479 @default.
- W2769866734 cites W2063235053 @default.
- W2769866734 cites W2064589328 @default.
- W2769866734 cites W2066042423 @default.
- W2769866734 cites W2066187384 @default.
- W2769866734 cites W2066352850 @default.
- W2769866734 cites W2067182537 @default.
- W2769866734 cites W2067617342 @default.
- W2769866734 cites W2067702255 @default.
- W2769866734 cites W2073492768 @default.
- W2769866734 cites W2077584398 @default.
- W2769866734 cites W2077955718 @default.
- W2769866734 cites W2078511386 @default.
- W2769866734 cites W2078680288 @default.
- W2769866734 cites W2079557411 @default.
- W2769866734 cites W2081338219 @default.
- W2769866734 cites W2081995492 @default.
- W2769866734 cites W2082645103 @default.
- W2769866734 cites W2083601115 @default.
- W2769866734 cites W2084298829 @default.
- W2769866734 cites W2088382955 @default.
- W2769866734 cites W2090565632 @default.
- W2769866734 cites W2093762865 @default.
- W2769866734 cites W2094667953 @default.
- W2769866734 cites W2096098547 @default.
- W2769866734 cites W2098346662 @default.
- W2769866734 cites W2109170913 @default.
- W2769866734 cites W2114270323 @default.
- W2769866734 cites W2122464318 @default.
- W2769866734 cites W2127616959 @default.
- W2769866734 cites W2134398800 @default.
- W2769866734 cites W2134610191 @default.
- W2769866734 cites W2135947496 @default.
- W2769866734 cites W2136862519 @default.
- W2769866734 cites W2138321923 @default.
- W2769866734 cites W2139806709 @default.
- W2769866734 cites W2140677834 @default.
- W2769866734 cites W2142812663 @default.
- W2769866734 cites W2143576515 @default.
- W2769866734 cites W2144867092 @default.
- W2769866734 cites W2145518547 @default.
- W2769866734 cites W2148596080 @default.
- W2769866734 cites W2149015598 @default.
- W2769866734 cites W2155252525 @default.
- W2769866734 cites W2157841288 @default.
- W2769866734 cites W2158111311 @default.
- W2769866734 cites W2160506388 @default.
- W2769866734 cites W2166048871 @default.
- W2769866734 cites W2177357938 @default.
- W2769866734 cites W2261440635 @default.
- W2769866734 cites W2317480464 @default.