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- W2769869238 abstract "BackgroundGlucocorticoids (GCs) play a critical role in regulating energy metabolism and are absolutely essential to life. In health, circulating levels of GCs are finely regulated by the hypothalamic-pituitary-adrenal (HPA) axis and follow circadian rhythmicity. GCs also have potent antiinflammatory effects with widespread therapeutic applications. GC excess states resulting from primary disorders of the HPA axis or therapeutic use are associated with metabolic derangements including obesity. Contrarily, obesity per se may also be associated with subtle anomalies of HPA function.MethodsIn this chapter we discuss the current understanding of associations between GCs, HPA axis function, and obesity based on both clinical and laboratory research. We also explore the role of circadian disruption in the pathophysiology of obesity.FindingsThe actions of GCs on adipose tissue are context-specific. Obesity is common in patients with endogenous or iatrogenic GC excess. Abnormalities have been demonstrated in HPA axis control, local fine regulation of GC levels, and the GC receptor itself in human obesity as well as experimental animal models of obesity. There is also some evidence of an association between abnormalities of the circadian HPA rhythm and obesity.ConclusionsOur evolving understanding of the complex relationships between GCs and obesity may lead to novel approaches to management of human obesity as well as development of innovative GC products for clinical applications that enhance therapeutic benefits while minimizing adverse effects." @default.
- W2769869238 created "2017-12-04" @default.
- W2769869238 creator A5047046246 @default.
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- W2769869238 date "2018-01-01" @default.
- W2769869238 modified "2023-09-26" @default.
- W2769869238 title "Obesity, Cortisol Excess, and the Hypothalamic–Pituitary–Adrenal Axis" @default.
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- W2769869238 doi "https://doi.org/10.1016/b978-0-323-48559-3.00004-x" @default.
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