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• W2769872823 abstract "This article traces the development of acyclic cucurbit[n]uril-type receptors with a focus on work from the Isaacs group. First, we describe the synthesis of methylene bridged glycoluril dimers capped with aromatic sidewalls which allowed us to probe the interconversion of the S- and C-shaped dimers which is a fundamental step in CB[n] formation. The C-shaped compounds were found to undergo discrete self-assembly (dimerization) in both water and organic solvents which lead us to investigate multicomponent self-sorting systems. We supressed the self-association of 8 by electrostatic repulsion in the putative dimer which allowed expression of its innate molecular recognition properties toward methylene blue and related planar cationic dyes. Longer glycoluril oligomers (trimer-hexamer, acyclic decamer) were prepared by starving the CB[n]-forming reaction of formaldehyde. The longer oligomers (e. g. 15 and 16) bind to alkylammonium ions in water ≈100-fold weaker than macrocyclic CB[n] highlighting the high preorganization of the acyclic but polycyclic framework. We prepared a wide variety of acyclic CB[n] compounds (wall variants, solubilizing group variants, linker variants) based on glycoluril trimer and tetramer. In particular, 26 and 27 have been shown to possess a wide variety of chemically and biologically interesting functions. For example, 26 was used to formulate the insoluble drug Albendazole and treat mice bearing SK-OV-3 xenograft tumors. Compound 27 binds tightly to the neuromuscular blocking agents rocuronium, vecuronium, and cisatracurium and acts as an in vivo reversal agent for these compounds in anesthetized rats. Container 27 was also found to modulate the hyperlocomotive effect of rats that had been treated with methamphetamine. Finally, 38 has been used as a cross reactive component of sensor arrays that are capable of classifying and quantifying cancer related nitroamine and a range of over the counter drugs. Overall, the work demonstrates that acyclic CB[n]-type compounds are nicely pre-organized and therefore retain the essential aspects of the recognition properties of macrocyclic CB[n] but allow for more straightforward tailoring of structure and solubility that enables a variety of chemically and biologically important applications." @default.
• W2769872823 created "2017-12-04" @default.
• W2769872823 creator A5053019957 @default.
• W2769872823 creator A5068678304 @default.
• W2769872823 date "2017-11-14" @default.
• W2769872823 modified "2023-10-15" @default.
• W2769872823 title "Acyclic Cucurbit[n]uril‐type Receptors: Preparation, Molecular Recognition Properties and Biological Applications" @default.
• W2769872823 cites W1608460191 @default.
• W2769872823 cites W1781421830 @default.
• W2769872823 cites W1928341221 @default.
• W2769872823 cites W1954070107 @default.
• W2769872823 cites W1964724705 @default.
• W2769872823 cites W1966536447 @default.
• W2769872823 cites W1970538392 @default.
• W2769872823 cites W1976723967 @default.
• W2769872823 cites W1977890967 @default.
• W2769872823 cites W1982810365 @default.
• W2769872823 cites W1983639282 @default.
• W2769872823 cites W1987252409 @default.
• W2769872823 cites W1987948865 @default.
• W2769872823 cites W1989419447 @default.
• W2769872823 cites W1992434579 @default.
• W2769872823 cites W1994384674 @default.
• W2769872823 cites W1997502039 @default.
• W2769872823 cites W2000415879 @default.
• W2769872823 cites W2000970293 @default.
• W2769872823 cites W2006011959 @default.
• W2769872823 cites W2012521191 @default.
• W2769872823 cites W2017108099 @default.
• W2769872823 cites W2018589296 @default.
• W2769872823 cites W2020451019 @default.
• W2769872823 cites W2021891281 @default.
• W2769872823 cites W2023772978 @default.
• W2769872823 cites W2024005625 @default.
• W2769872823 cites W2026085713 @default.
• W2769872823 cites W2026562094 @default.
• W2769872823 cites W2028519893 @default.
• W2769872823 cites W2033560751 @default.
• W2769872823 cites W2033791004 @default.
• W2769872823 cites W2034961303 @default.
• W2769872823 cites W2036079026 @default.
• W2769872823 cites W2040437294 @default.
• W2769872823 cites W2043672286 @default.
• W2769872823 cites W2047669007 @default.
• W2769872823 cites W2054125712 @default.
• W2769872823 cites W2055957451 @default.
• W2769872823 cites W2057940109 @default.
• W2769872823 cites W2067841092 @default.
• W2769872823 cites W2068017438 @default.
• W2769872823 cites W2069635793 @default.
• W2769872823 cites W2072004833 @default.
• W2769872823 cites W2074089202 @default.
• W2769872823 cites W2074984060 @default.
• W2769872823 cites W2077762017 @default.
• W2769872823 cites W2079187051 @default.
• W2769872823 cites W2082113004 @default.
• W2769872823 cites W2089138996 @default.
• W2769872823 cites W2091068412 @default.
• W2769872823 cites W2095422424 @default.
• W2769872823 cites W2106346416 @default.
• W2769872823 cites W2114582584 @default.
• W2769872823 cites W2120520995 @default.
• W2769872823 cites W2124548476 @default.
• W2769872823 cites W2127943087 @default.
• W2769872823 cites W2131074035 @default.
• W2769872823 cites W2145271930 @default.
• W2769872823 cites W2145572439 @default.
• W2769872823 cites W2150223648 @default.
• W2769872823 cites W215025240 @default.
• W2769872823 cites W2154063883 @default.
• W2769872823 cites W2155603053 @default.
• W2769872823 cites W2156453117 @default.
• W2769872823 cites W2159279834 @default.
• W2769872823 cites W2160134664 @default.
• W2769872823 cites W2162288181 @default.
• W2769872823 cites W2164227888 @default.
• W2769872823 cites W2169647229 @default.
• W2769872823 cites W2182715526 @default.
• W2769872823 cites W2190830215 @default.
• W2769872823 cites W2192072986 @default.
• W2769872823 cites W2238347679 @default.
• W2769872823 cites W2302139040 @default.
• W2769872823 cites W2302177229 @default.
• W2769872823 cites W2313327927 @default.
• W2769872823 cites W2316954248 @default.
• W2769872823 cites W2317136863 @default.
• W2769872823 cites W2317862353 @default.
• W2769872823 cites W2321866038 @default.
• W2769872823 cites W2339442418 @default.
• W2769872823 cites W2410599549 @default.
• W2769872823 cites W2423286889 @default.
• W2769872823 cites W2481601915 @default.
• W2769872823 cites W2498629009 @default.
• W2769872823 cites W2559177805 @default.
• W2769872823 cites W2560173039 @default.
• W2769872823 cites W2610592973 @default.
• W2769872823 cites W2615803592 @default.
• W2769872823 cites W2624514819 @default.

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