Matches in SemOpenAlex for { <https://semopenalex.org/work/W2769872877> ?p ?o ?g. }
- W2769872877 endingPage "17986" @default.
- W2769872877 startingPage "17979" @default.
- W2769872877 abstract "The field of photopharmacology aims to introduce smart drugs that, through the incorporation of molecular photoswitches, allow for the remote spatial and temporal control of bioactivity by light. This concept could be particularly beneficial in the treatment of bacterial infections, by reducing the systemic and environmental side effects of antibiotics. A major concern in the realization of such light-responsive drugs is the wavelength of the light that is applied. Studies on the photocontrol of biologically active agents mostly rely on UV light, which is cytotoxic and poorly suited for tissue penetration. In our efforts to develop photoswitchable antibiotics, we introduce here antibacterial agents whose activity can be controlled by visible light, while getting into the therapeutic window. For that purpose, a UV-light-responsive core structure based on diaminopyrimidines with suitable antibacterial properties was identified. Subsequent modification of an azobenzene photoswitch moiety led to structures that allowed us to control their activity against Escherichia coli in both directions with light in the visible region. For the first time, full in situ photocontrol of antibacterial activity in the presence of bacteria was attained with green and violet light. Most remarkably, one of the diaminopyrimidines revealed an at least 8-fold difference in activity before and after irradiation with red light at 652 nm, showcasing the effective activation of a biological agent otherwise inactive within the investigated concentration range, and doing so with red light in the therapeutic window." @default.
- W2769872877 created "2017-12-04" @default.
- W2769872877 creator A5006401636 @default.
- W2769872877 creator A5010327184 @default.
- W2769872877 creator A5030298371 @default.
- W2769872877 creator A5033546736 @default.
- W2769872877 creator A5068549255 @default.
- W2769872877 date "2017-11-28" @default.
- W2769872877 modified "2023-10-16" @default.
- W2769872877 title "Photocontrol of Antibacterial Activity: Shifting from UV to Red Light Activation" @default.
- W2769872877 cites W1546474542 @default.
- W2769872877 cites W1836441987 @default.
- W2769872877 cites W1854857428 @default.
- W2769872877 cites W1903778810 @default.
- W2769872877 cites W1918048000 @default.
- W2769872877 cites W1964171417 @default.
- W2769872877 cites W1967245883 @default.
- W2769872877 cites W1969525682 @default.
- W2769872877 cites W1971933638 @default.
- W2769872877 cites W1986648865 @default.
- W2769872877 cites W1993456678 @default.
- W2769872877 cites W1993777583 @default.
- W2769872877 cites W1994296952 @default.
- W2769872877 cites W2009094782 @default.
- W2769872877 cites W2009483611 @default.
- W2769872877 cites W2010856072 @default.
- W2769872877 cites W2011393168 @default.
- W2769872877 cites W2013294070 @default.
- W2769872877 cites W2017740377 @default.
- W2769872877 cites W2017815870 @default.
- W2769872877 cites W2018593882 @default.
- W2769872877 cites W2022541259 @default.
- W2769872877 cites W2030291055 @default.
- W2769872877 cites W2038074501 @default.
- W2769872877 cites W2041419503 @default.
- W2769872877 cites W2043458609 @default.
- W2769872877 cites W2047785511 @default.
- W2769872877 cites W2052822556 @default.
- W2769872877 cites W2076221934 @default.
- W2769872877 cites W2079228339 @default.
- W2769872877 cites W2085363005 @default.
- W2769872877 cites W2093285141 @default.
- W2769872877 cites W2095565245 @default.
- W2769872877 cites W2096160034 @default.
- W2769872877 cites W2100130506 @default.
- W2769872877 cites W2103459003 @default.
- W2769872877 cites W2104750028 @default.
- W2769872877 cites W2104750596 @default.
- W2769872877 cites W2105742053 @default.
- W2769872877 cites W2106569917 @default.
- W2769872877 cites W2112817434 @default.
- W2769872877 cites W2112927475 @default.
- W2769872877 cites W2115911602 @default.
- W2769872877 cites W2116281974 @default.
- W2769872877 cites W2118778931 @default.
- W2769872877 cites W2122951513 @default.
- W2769872877 cites W2130408429 @default.
- W2769872877 cites W2132911648 @default.
- W2769872877 cites W2133193437 @default.
- W2769872877 cites W2136425784 @default.
- W2769872877 cites W2136532823 @default.
- W2769872877 cites W2136936563 @default.
- W2769872877 cites W2140216615 @default.
- W2769872877 cites W2143154743 @default.
- W2769872877 cites W2148734015 @default.
- W2769872877 cites W2158094776 @default.
- W2769872877 cites W2159220210 @default.
- W2769872877 cites W2164163739 @default.
- W2769872877 cites W2171490806 @default.
- W2769872877 cites W2232308294 @default.
- W2769872877 cites W2270252149 @default.
- W2769872877 cites W2293816282 @default.
- W2769872877 cites W2316938870 @default.
- W2769872877 cites W2330760879 @default.
- W2769872877 cites W2333696289 @default.
- W2769872877 cites W2334735170 @default.
- W2769872877 cites W2337268330 @default.
- W2769872877 cites W2411365085 @default.
- W2769872877 cites W2421408924 @default.
- W2769872877 cites W2434425896 @default.
- W2769872877 cites W2463040786 @default.
- W2769872877 cites W2469713039 @default.
- W2769872877 cites W2525820484 @default.
- W2769872877 cites W2532153351 @default.
- W2769872877 cites W2736251649 @default.
- W2769872877 cites W4211018053 @default.
- W2769872877 cites W4248665292 @default.
- W2769872877 cites W96208462 @default.
- W2769872877 doi "https://doi.org/10.1021/jacs.7b09281" @default.
- W2769872877 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5730949" @default.
- W2769872877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29136373" @default.
- W2769872877 hasPublicationYear "2017" @default.
- W2769872877 type Work @default.
- W2769872877 sameAs 2769872877 @default.
- W2769872877 citedByCount "214" @default.
- W2769872877 countsByYear W27698728772018 @default.
- W2769872877 countsByYear W27698728772019 @default.
- W2769872877 countsByYear W27698728772020 @default.