FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2769873729> ?p ?o ?g. }

• W2769873729 abstract "Despite therapeutic advances, heart failure-related mortality rates remain high. Therefore, understanding the pathophysiological mechanisms involved in the remodeling process is crucial for the development of new therapeutic strategies. Andrographolide (Andr), a botanical compound, has potent cardio-protective effects due to its ability to inhibit mitogen-activated protein kinases (MAPKs). Andr has also been shown to inhibit inflammation and apoptosis, which are factors related to cardiac hypertrophy. Our aim was to evaluate the effects of Andr on cardiac hypertrophy and MAPKs activation. Thus, mice were subjected to aortic banding (AB) with/without Andr administration (25 mg/kg/day, orally). Cardiac function was accessed by echocardiography and hemodynamic parameters. Our results showed that Andr administration for 7 weeks decreased cardiac dysfunction and attenuated cardiac hypertrophy and fibrosis in AB mice. Andr treatment induced a strong reduction in the transcription of both hypertrophy (ANP, BNP, and β-MHC) and fibrosis related genes (collagen I, collagen III, CTGF, and TGFβ). In addition, cardiomyocytes treated with Andr showed a reduced hypertrophic response to angiotensin II. Andr significantly inhibited MAPKs activation in both mouse hearts and cardiomyocytes. Treatment with a combination of MAPKs activators abolished the protective effects of Andr in cardiomyocytes. Furthermore, we found that Andr also inhibited the activation of cardiac fibroblasts via the MAPKs pathway, which was confirmed by the application of MAPKs inhibitors. In conclusion, Andr was found to confer a protective effect against experimental cardiac hypertrophy in mice, suggesting its potential as a novel therapeutic drug for pathological cardiac hypertrophy." @default.
• W2769873729 created "2017-12-04" @default.
• W2769873729 creator A5031987801 @default.
• W2769873729 creator A5048146081 @default.
• W2769873729 creator A5054418515 @default.
• W2769873729 creator A5069016717 @default.
• W2769873729 creator A5080674121 @default.
• W2769873729 creator A5083069101 @default.
• W2769873729 date "2017-11-14" @default.
• W2769873729 modified "2023-10-12" @default.
• W2769873729 title "Andrographolide Protects against Aortic Banding-Induced Experimental Cardiac Hypertrophy by Inhibiting MAPKs Signaling" @default.
• W2769873729 cites W1529862612 @default.
• W2769873729 cites W1599680785 @default.
• W2769873729 cites W1757461034 @default.
• W2769873729 cites W1872512649 @default.
• W2769873729 cites W1977303730 @default.
• W2769873729 cites W1981125871 @default.
• W2769873729 cites W1989434611 @default.
• W2769873729 cites W1992728554 @default.
• W2769873729 cites W2011251969 @default.
• W2769873729 cites W2016193552 @default.
• W2769873729 cites W2023659954 @default.
• W2769873729 cites W2029762560 @default.
• W2769873729 cites W2030086780 @default.
• W2769873729 cites W2031217240 @default.
• W2769873729 cites W2040888486 @default.
• W2769873729 cites W2056028095 @default.
• W2769873729 cites W2058301500 @default.
• W2769873729 cites W2063346793 @default.
• W2769873729 cites W2071038507 @default.
• W2769873729 cites W2075907691 @default.
• W2769873729 cites W2094650613 @default.
• W2769873729 cites W2096847688 @default.
• W2769873729 cites W2102289477 @default.
• W2769873729 cites W2107751591 @default.
• W2769873729 cites W2149724396 @default.
• W2769873729 cites W2164152829 @default.
• W2769873729 cites W2168444924 @default.
• W2769873729 cites W2265348944 @default.
• W2769873729 cites W2266148525 @default.
• W2769873729 cites W2299099463 @default.
• W2769873729 cites W2311739205 @default.
• W2769873729 cites W2327307773 @default.
• W2769873729 cites W2415715899 @default.
• W2769873729 cites W2474517402 @default.
• W2769873729 cites W2485866451 @default.
• W2769873729 cites W2513788684 @default.
• W2769873729 cites W2514531847 @default.
• W2769873729 cites W2518476176 @default.
• W2769873729 cites W2521305453 @default.
• W2769873729 cites W2528106761 @default.
• W2769873729 cites W2529353499 @default.
• W2769873729 cites W2529759632 @default.
• W2769873729 cites W2588583241 @default.
• W2769873729 cites W2597258638 @default.
• W2769873729 cites W2605431070 @default.
• W2769873729 cites W2617621640 @default.
• W2769873729 cites W2623852148 @default.
• W2769873729 cites W2725589659 @default.
• W2769873729 cites W2748662585 @default.
• W2769873729 cites W4232767515 @default.
• W2769873729 doi "https://doi.org/10.3389/fphar.2017.00808" @default.
• W2769873729 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5694538" @default.
• W2769873729 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29184496" @default.
• W2769873729 hasPublicationYear "2017" @default.
• W2769873729 type Work @default.
• W2769873729 sameAs 2769873729 @default.
• W2769873729 citedByCount "25" @default.
• W2769873729 countsByYear W27698737292018 @default.
• W2769873729 countsByYear W27698737292019 @default.
• W2769873729 countsByYear W27698737292020 @default.
• W2769873729 countsByYear W27698737292021 @default.
• W2769873729 countsByYear W27698737292022 @default.
• W2769873729 countsByYear W27698737292023 @default.
• W2769873729 crossrefType "journal-article" @default.
• W2769873729 hasAuthorship W2769873729A5031987801 @default.
• W2769873729 hasAuthorship W2769873729A5048146081 @default.
• W2769873729 hasAuthorship W2769873729A5054418515 @default.
• W2769873729 hasAuthorship W2769873729A5069016717 @default.
• W2769873729 hasAuthorship W2769873729A5080674121 @default.
• W2769873729 hasAuthorship W2769873729A5083069101 @default.
• W2769873729 hasBestOaLocation W27698737291 @default.
• W2769873729 hasConcept C111566952 @default.
• W2769873729 hasConcept C126322002 @default.
• W2769873729 hasConcept C134018914 @default.
• W2769873729 hasConcept C167414201 @default.
• W2769873729 hasConcept C170493617 @default.
• W2769873729 hasConcept C184235292 @default.
• W2769873729 hasConcept C2775960820 @default.
• W2769873729 hasConcept C2776914184 @default.
• W2769873729 hasConcept C2777420927 @default.
• W2769873729 hasConcept C2778198053 @default.
• W2769873729 hasConcept C2779537366 @default.
• W2769873729 hasConcept C2780559512 @default.
• W2769873729 hasConcept C2780631158 @default.
• W2769873729 hasConcept C2781357234 @default.
• W2769873729 hasConcept C2908929049 @default.
• W2769873729 hasConcept C51551487 @default.
• W2769873729 hasConcept C57074206 @default.
• W2769873729 hasConcept C71924100 @default.

• next