Matches in SemOpenAlex for { <https://semopenalex.org/work/W2769876619> ?p ?o ?g. }
- W2769876619 endingPage "202" @default.
- W2769876619 startingPage "187" @default.
- W2769876619 abstract "Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease that leads to death. No effective treatments are currently available. Based on data from epidemiological, etiological, laboratory, and clinical studies, I offer a new way of thinking about ALS and its treatment. This paper describes a host of extrinsic factors, including the exposome, that disrupt the extracellular matrix and protein function such that a spreading, prion-like disease leads to neurodegeneration in the motor tracts. A treatment regimen is described using the stem cell released molecules from a number of types of adult stem cells to provide tissue dependent molecules that restore homeostasis, including proteostasis, in the ALS patient. Because stem cells themselves as a therapeutic are cumbersome and expensive, and when implanted in a host cause aging of the host tissue and often fail to engraft or remain viable, only the S2RM molecules are used. Rebuilding of the extracellular matrix and repair of the dysfunctional proteins in the ALS patient ensues." @default.
- W2769876619 created "2017-12-04" @default.
- W2769876619 creator A5044375589 @default.
- W2769876619 date "2017-11-26" @default.
- W2769876619 modified "2023-09-26" @default.
- W2769876619 title "Amyotrophic lateral sclerosis as a protein level, non-genomic disease: Therapy with S2RM exosome released molecules" @default.
- W2769876619 cites W1503916499 @default.
- W2769876619 cites W1601534163 @default.
- W2769876619 cites W1688677061 @default.
- W2769876619 cites W1913779731 @default.
- W2769876619 cites W1970964887 @default.
- W2769876619 cites W1972011171 @default.
- W2769876619 cites W1973721788 @default.
- W2769876619 cites W1974332498 @default.
- W2769876619 cites W1974448552 @default.
- W2769876619 cites W1978610997 @default.
- W2769876619 cites W1979043025 @default.
- W2769876619 cites W1979432223 @default.
- W2769876619 cites W1981391950 @default.
- W2769876619 cites W1982345208 @default.
- W2769876619 cites W1982408656 @default.
- W2769876619 cites W1990861851 @default.
- W2769876619 cites W1992057876 @default.
- W2769876619 cites W1992757367 @default.
- W2769876619 cites W1998150563 @default.
- W2769876619 cites W2001913172 @default.
- W2769876619 cites W2003205286 @default.
- W2769876619 cites W2007753040 @default.
- W2769876619 cites W2016542343 @default.
- W2769876619 cites W2018863540 @default.
- W2769876619 cites W2019964230 @default.
- W2769876619 cites W2020061739 @default.
- W2769876619 cites W2023866076 @default.
- W2769876619 cites W2024481135 @default.
- W2769876619 cites W2031084334 @default.
- W2769876619 cites W2033236350 @default.
- W2769876619 cites W2034722616 @default.
- W2769876619 cites W2035074912 @default.
- W2769876619 cites W2035922209 @default.
- W2769876619 cites W2036561191 @default.
- W2769876619 cites W2038745406 @default.
- W2769876619 cites W2040891140 @default.
- W2769876619 cites W2043443341 @default.
- W2769876619 cites W2053369230 @default.
- W2769876619 cites W2055917728 @default.
- W2769876619 cites W2059355164 @default.
- W2769876619 cites W2060365113 @default.
- W2769876619 cites W2060387475 @default.
- W2769876619 cites W2060944544 @default.
- W2769876619 cites W2066354291 @default.
- W2769876619 cites W2066842081 @default.
- W2769876619 cites W2067251469 @default.
- W2769876619 cites W2067406680 @default.
- W2769876619 cites W2069842601 @default.
- W2769876619 cites W2071068942 @default.
- W2769876619 cites W2073415176 @default.
- W2769876619 cites W2085656073 @default.
- W2769876619 cites W2086243699 @default.
- W2769876619 cites W2090419287 @default.
- W2769876619 cites W2096776344 @default.
- W2769876619 cites W2099756790 @default.
- W2769876619 cites W2105683943 @default.
- W2769876619 cites W2105996005 @default.
- W2769876619 cites W2107787446 @default.
- W2769876619 cites W2110308292 @default.
- W2769876619 cites W2114080032 @default.
- W2769876619 cites W2117862630 @default.
- W2769876619 cites W2121587342 @default.
- W2769876619 cites W2122686110 @default.
- W2769876619 cites W2125093810 @default.
- W2769876619 cites W2128526467 @default.
- W2769876619 cites W2129155846 @default.
- W2769876619 cites W2129710588 @default.
- W2769876619 cites W2133646321 @default.
- W2769876619 cites W2134219545 @default.
- W2769876619 cites W2136896331 @default.
- W2769876619 cites W2150523249 @default.
- W2769876619 cites W2151328705 @default.
- W2769876619 cites W2157076525 @default.
- W2769876619 cites W2157917165 @default.
- W2769876619 cites W2164647869 @default.
- W2769876619 cites W2166236051 @default.
- W2769876619 cites W2171873547 @default.
- W2769876619 cites W2172019611 @default.
- W2769876619 cites W2173499412 @default.
- W2769876619 cites W2181079527 @default.
- W2769876619 cites W2201382378 @default.
- W2769876619 cites W2202126265 @default.
- W2769876619 cites W2224270925 @default.
- W2769876619 cites W2228446732 @default.
- W2769876619 cites W2234902113 @default.
- W2769876619 cites W2236767140 @default.
- W2769876619 cites W2239259805 @default.
- W2769876619 cites W2294236573 @default.
- W2769876619 cites W2304223632 @default.
- W2769876619 cites W2307456086 @default.
- W2769876619 cites W2311565791 @default.
- W2769876619 cites W2313673704 @default.