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• W2769883386 abstract "ABSTRACT The increasing incidence of multidrug-resistant Acinetobacter baumannii (MDR Ab ) infections worldwide has necessitated the development of novel antibiotics. Human defensin 5 (HD5) is an endogenous peptide with a complex architecture and antibacterial activity against MDR Ab . In the present study, we attempted to simplify the structure of HD5 by removing disulfide bonds. We found that the Cys2-4 bond was most indispensable for HD5 to inactivate MDR Ab , although the antibacterial activity of the derivative was significantly attenuated. We then replaced the noncationic and nonhydrophobic residues with electropositive Arg to increase the antibacterial activity of HD5 derivative that contains a Cys2-4 bond, obtaining another derivative termed HD5d5. The in vitro antibacterial assay and irradiation-wound-infection animal experiment both showed that HD5d5 was much more effective than HD5 at eliminating MDR Ab . Further investigations revealed that HD5d5 efficiently bound to outer membrane lipid A and penetrated membranes, leading to bacterial collapse and peptide translocation. Compared to HD5, more HD5d5 molecules were located in the cytoplasm of MDR Ab , and HD5d5 was more efficient at reducing the activities of superoxide dismutase and catalase, causing the accumulation of reactive oxygen species that are detrimental to microbes. In addition, HD5 failed to suppress the pathogenic outer membrane protein A of Acinetobacter baumannii ( Ab OmpA) at concentrations up to 50 μg/ml, whereas HD5d5 strongly bound to Ab OmpA and exhibited a dramatic toxin-neutralizing ability, thus expanding the repertoire of drugs that is available to treat MDR Ab infections." @default.
• W2769883386 created "2017-12-04" @default.
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• W2769883386 date "2018-02-01" @default.
• W2769883386 modified "2023-10-12" @default.
• W2769883386 title "A Simplified Derivative of Human Defensin 5 with Potent and Efficient Activity against Multidrug-Resistant Acinetobacter baumannii" @default.
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• W2769883386 doi "https://doi.org/10.1128/aac.01504-17" @default.
• W2769883386 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5786806" @default.
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