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- W2769892387 endingPage "301" @default.
- W2769892387 startingPage "295" @default.
- W2769892387 abstract "ABSTRACT Capillary rarefaction is broadly defined as a reduction in vascular density. Capillary rarefaction in the kidneys is thought to promote hypoxia, impair hemodynamic responses and predispose to chronic kidney disease (CKD) progression and hypertension development. Various mechanisms have been suggested to play a role in the development of capillary rarefaction, including inflammation, an altered endothelial-tubular epithelial cell crosstalk, a relative deficiency in angiogenic growth factors, loss of pericytes, increased activity of Transforming growth factor -β1 and thrombospondin-1, vitamin D deficiency, a link to lymphatic neoangiogenesis and INK4a/ARF (Cylin-dependent kinase inhibitor 2a; CDKN2A). In this review, we summarize the tools available to monitor capillary rarefaction noninvasively in the clinic, the contribution of capillary rarefaction to CKD and hypertension, the known mechanisms of capillary rarefaction, and potential future strategies to attenuate capillary rarefaction and reduce its negative impact. Therapeutic strategies to be explored in more detail include optimization of antihypertensive therapy, vitamin D receptor activators, sirtuin 1 activators, Hypoxia inducible factor prolyl hydroxylase inhibitors and stem cell therapy." @default.
- W2769892387 created "2017-12-04" @default.
- W2769892387 creator A5004647379 @default.
- W2769892387 creator A5010857914 @default.
- W2769892387 creator A5022715104 @default.
- W2769892387 creator A5038581292 @default.
- W2769892387 creator A5053042370 @default.
- W2769892387 creator A5055537806 @default.
- W2769892387 creator A5056673554 @default.
- W2769892387 creator A5065210768 @default.
- W2769892387 date "2017-11-28" @default.
- W2769892387 modified "2023-10-16" @default.
- W2769892387 title "Capillary rarefaction from the kidney point of view" @default.
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