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• W2769893818 endingPage "633" @default.
• W2769893818 startingPage "633" @default.
• W2769893818 abstract "The aim of this study is to investigate the effects of intermittent ladder-climbing exercise training on mitochondrial biogenesis and ER stress of the cardiac muscle in high fat diet-induced obese middle-aged rats. We induced obesity over 6 weeks of period in 40 male Sprague-Dawley rats around 50 weeks old, and were randomly divided into four experimental groups: chow, HFD, exercise+HFD, and exercise+chow. The exercising groups underwent high-intensity intermittent training using a ladder-climbing and weight exercise 3 days/week for a total of 8 weeks. High-fat diet and concurrent exercise resulted in no significant reduction in body weight but caused a significant reduction in visceral fat weight (p<0.05). Expression of PPARδ increased in the exercise groups and was significantly increased in the high-fat diet+exercise group (p<0.05). Among the ER stress-related proteins, the expression levels of p-PERK and CHOP, related to cardiac muscle damage, were significantly higher in the cardiac muscle of the high-fat diet group (p<0.05), and were significantly reduced by intermittent ladder-climbing exercise training (p<0.05). Specifically, this reduction was greater when the rats underwent exercise after switching back to the chow diet with a reduced caloric intake. Collectively, these results suggest that the combination of intermittent ladder-climbing exercise training and a reduced caloric intake can decrease the levels of ER stress-related proteins that contribute to cardiac muscle damage in obesity and aging. However, additional validation is required to understand the effects of these changes on mitochondrial biogenesis during exercise." @default.
• W2769893818 created "2017-12-04" @default.
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• W2769893818 creator A5046950649 @default.
• W2769893818 date "2017-01-01" @default.
• W2769893818 modified "2023-09-27" @default.
• W2769893818 title "Effects of intermittent ladder-climbing exercise training on mitochondrial biogenesis and endoplasmic reticulum stress of the cardiac muscle in obese middle-aged rats" @default.
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• W2769893818 doi "https://doi.org/10.4196/kjpp.2017.21.6.633" @default.
• W2769893818 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5709480" @default.
• W2769893818 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29200906" @default.
• W2769893818 hasPublicationYear "2017" @default.
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