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- W2769898086 abstract "Phosphatidylinositol 3-P (PI3P) is a signaling molecule that controls a variety of processes in endosomal, autophagic, and vacuolar/lysosomal trafficking in yeasts and mammals. Vacuolar protein sorting 34 (Vps34) is a conserved PI3K present in multiple complexes with specific functions and regulation. In yeast, the PI3K complex II consists of Vps34p, Vps15p, Vps30p/Atg6p, and Vps38p, and is essential for vacuolar protein sorting. Here, we describe the Arabidopsis (Arabidopsis thaliana) homolog of yeast Vps38p and human UV radiation resistance-associated gene protein. Arabidopsis VPS38 interacts with VPS30/ATG6 both in yeast and in planta. Although the level of PI3P in Arabidopsis vps38 mutants is similar to that in wild type, vps38 cells contain enlarged multivesicular endosomes and fewer organelles enriched in PI3P than the wild type. The vps38 mutants are defective in the trafficking of vacuolar cargo and its receptor VACUOLAR SORTING RECEPTOR2;1. The mutants also exhibit abnormal cytoplasmic distributions of endocytic cargo, such as auxin efflux carriers PINFORMED1 (PIN1) and PIN2. Constitutive autophagy is normal in the mutants but starvation-induced autophagy was slightly inhibited. We conclude that Arabidopsis VPS38 is dispensable for autophagy but essential for efficient targeting of biosynthetic and endocytic cargo to the vacuole." @default.
- W2769898086 created "2017-12-04" @default.
- W2769898086 creator A5018933458 @default.
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- W2769898086 date "2017-11-28" @default.
- W2769898086 modified "2023-09-30" @default.
- W2769898086 title "Vacuolar Trafficking Protein VPS38 Is Dispensable for Autophagy" @default.
- W2769898086 cites W1562982734 @default.
- W2769898086 cites W1958373838 @default.
- W2769898086 cites W1965871489 @default.
- W2769898086 cites W1967085696 @default.
- W2769898086 cites W1967601510 @default.
- W2769898086 cites W1972673360 @default.
- W2769898086 cites W1978179863 @default.
- W2769898086 cites W1986105167 @default.
- W2769898086 cites W1991869583 @default.
- W2769898086 cites W2006176190 @default.
- W2769898086 cites W2008642796 @default.
- W2769898086 cites W2008745495 @default.
- W2769898086 cites W2009490810 @default.
- W2769898086 cites W2013544053 @default.
- W2769898086 cites W2022185284 @default.
- W2769898086 cites W2028684967 @default.
- W2769898086 cites W2042610900 @default.
- W2769898086 cites W2042838204 @default.
- W2769898086 cites W2042915641 @default.
- W2769898086 cites W2051071158 @default.
- W2769898086 cites W2052618262 @default.
- W2769898086 cites W2056184573 @default.
- W2769898086 cites W2060162734 @default.
- W2769898086 cites W2060622315 @default.
- W2769898086 cites W2068588120 @default.
- W2769898086 cites W2069925585 @default.
- W2769898086 cites W2073223481 @default.
- W2769898086 cites W2076720615 @default.
- W2769898086 cites W2092414917 @default.
- W2769898086 cites W2092438458 @default.
- W2769898086 cites W2096646958 @default.
- W2769898086 cites W2099160414 @default.
- W2769898086 cites W2099923238 @default.
- W2769898086 cites W2100565730 @default.
- W2769898086 cites W2101989800 @default.
- W2769898086 cites W2105189362 @default.
- W2769898086 cites W2105868453 @default.
- W2769898086 cites W2107004026 @default.
- W2769898086 cites W2107127679 @default.
- W2769898086 cites W2107277218 @default.
- W2769898086 cites W2109323673 @default.
- W2769898086 cites W2110448073 @default.
- W2769898086 cites W2115779663 @default.
- W2769898086 cites W2116122104 @default.
- W2769898086 cites W2119556473 @default.
- W2769898086 cites W2120457759 @default.
- W2769898086 cites W2120642808 @default.
- W2769898086 cites W2120762768 @default.
- W2769898086 cites W2122826962 @default.
- W2769898086 cites W2123762144 @default.
- W2769898086 cites W2124100949 @default.
- W2769898086 cites W2124228487 @default.
- W2769898086 cites W2128097362 @default.
- W2769898086 cites W2132396512 @default.
- W2769898086 cites W2132926880 @default.
- W2769898086 cites W2133153033 @default.
- W2769898086 cites W2133284292 @default.
- W2769898086 cites W2137095142 @default.
- W2769898086 cites W2145691696 @default.
- W2769898086 cites W2146094825 @default.
- W2769898086 cites W2147228753 @default.
- W2769898086 cites W2149091307 @default.
- W2769898086 cites W2151001790 @default.
- W2769898086 cites W2151456890 @default.
- W2769898086 cites W2152207030 @default.
- W2769898086 cites W2154993563 @default.
- W2769898086 cites W2155175976 @default.
- W2769898086 cites W2156243692 @default.
- W2769898086 cites W2160927614 @default.
- W2769898086 cites W2161944136 @default.
- W2769898086 cites W2162889213 @default.
- W2769898086 cites W2163144695 @default.
- W2769898086 cites W2163448850 @default.
- W2769898086 cites W2167145530 @default.
- W2769898086 cites W2169583594 @default.
- W2769898086 cites W2171257497 @default.
- W2769898086 cites W2192080449 @default.
- W2769898086 cites W2214645750 @default.
- W2769898086 cites W2301500880 @default.
- W2769898086 cites W2411578030 @default.
- W2769898086 cites W2431499568 @default.
- W2769898086 cites W2554261818 @default.
- W2769898086 cites W4249895984 @default.