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• W2769905082 abstract "Abstract Mitochondrial activity in cells must be tightly controlled in response to changes in intracellular circumstances. Despite drastic changes in intracellular conditions and mitochondrial morphology, it is not clear how mitochondrial activity is controlled during M phase of the cell cycle. Here, we show that mitochondrial activity is drastically changed during M phase. Mitochondrial membrane potential changed during M phase progression. Mitochondria were polarized until metaphase to the same extent as mitochondria in interphase cells, but were depolarized at around telophase and cytokinesis. After cytokinesis, mitochondrial membrane potential was recovered. In addition, the generation of superoxide anions in mitochondria was significantly reduced at metaphase even in the presence of antimycin A, an inhibitor of complex III. These results suggest that the electron supply to the mitochondrial electron transfer chain is suppressed during M phase. This suppression might decrease the reactive oxygen species generated by the fragmentation of mitochondria during M phase." @default.
• W2769905082 created "2017-12-04" @default.
• W2769905082 creator A5038435049 @default.
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• W2769905082 date "2017-11-22" @default.
• W2769905082 modified "2023-10-10" @default.
• W2769905082 title "Temporal depolarization of mitochondria during M phase" @default.
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• W2769905082 doi "https://doi.org/10.1038/s41598-017-15907-3" @default.
• W2769905082 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5700041" @default.
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• W2769905082 hasPublicationYear "2017" @default.
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