Matches in SemOpenAlex for { <https://semopenalex.org/work/W2770027655> ?p ?o ?g. }
- W2770027655 endingPage "109" @default.
- W2770027655 startingPage "101" @default.
- W2770027655 abstract "Psoriasis exhibits several extracutaneous manifestations. Little is known about hepatic parameters specifically associated with psoriasis.To study whether psoriasiform dermatitis is associated with liver injury.We studied liver parameters of inflammation and fibrosis in a murine model of psoriasiform dermatitis induced by topical application of imiquimod for 9 weeks.Topical treatment with imiquimod induced a form of psoriasiform dermatitis reminiscent of the human disorder, characterized by thickened and scaly skin, psoriasiform epidermal hyperplasia, altered keratinocyte differentiation and cutaneous overexpression of interleukin-17A. Mice with dermatitis displayed hepatitis, as shown by elevation of plasma transaminase levels, as well as portal and periportal hepatitis, characterized by T-lymphocyte (CD3ε+ ) and polymorphonuclear cell (Gr1+ ) infiltrates. The hepatitis progressed towards liver fibrogenesis, as shown by excessive Sirius red staining, which is consistent with the expression of α-smooth muscle actin by hepatic stellate cells.These results indicate that liver inflammation and fibrosis are associated with experimental psoriasiform dermatitis. Our results suggest that psoriatic inflammation may be associated with specific liver injury." @default.
- W2770027655 created "2017-12-04" @default.
- W2770027655 creator A5006023928 @default.
- W2770027655 creator A5013922423 @default.
- W2770027655 creator A5015131799 @default.
- W2770027655 creator A5015975130 @default.
- W2770027655 creator A5039656288 @default.
- W2770027655 creator A5049469990 @default.
- W2770027655 creator A5063262332 @default.
- W2770027655 creator A5072738641 @default.
- W2770027655 creator A5072756206 @default.
- W2770027655 date "2018-04-14" @default.
- W2770027655 modified "2023-09-25" @default.
- W2770027655 title "Liver fibrosis is associated with cutaneous inflammation in the imiquimod-induced murine model of psoriasiform dermatitis" @default.
- W2770027655 cites W1483095827 @default.
- W2770027655 cites W1580232799 @default.
- W2770027655 cites W1593318392 @default.
- W2770027655 cites W1939997832 @default.
- W2770027655 cites W1950019186 @default.
- W2770027655 cites W1958716837 @default.
- W2770027655 cites W1962929997 @default.
- W2770027655 cites W1969775578 @default.
- W2770027655 cites W1976313883 @default.
- W2770027655 cites W1976544953 @default.
- W2770027655 cites W1977317069 @default.
- W2770027655 cites W1981900811 @default.
- W2770027655 cites W1987784314 @default.
- W2770027655 cites W1994897754 @default.
- W2770027655 cites W1994919731 @default.
- W2770027655 cites W2000369852 @default.
- W2770027655 cites W2007651365 @default.
- W2770027655 cites W2016438270 @default.
- W2770027655 cites W2022665587 @default.
- W2770027655 cites W2035504790 @default.
- W2770027655 cites W2046088186 @default.
- W2770027655 cites W2052368620 @default.
- W2770027655 cites W2059884846 @default.
- W2770027655 cites W2066752983 @default.
- W2770027655 cites W2072831792 @default.
- W2770027655 cites W2076154029 @default.
- W2770027655 cites W2088719734 @default.
- W2770027655 cites W2093577520 @default.
- W2770027655 cites W2126714545 @default.
- W2770027655 cites W2137203424 @default.
- W2770027655 cites W2146444857 @default.
- W2770027655 cites W2151566115 @default.
- W2770027655 cites W2161945877 @default.
- W2770027655 cites W2165668974 @default.
- W2770027655 cites W2171925512 @default.
- W2770027655 cites W2321050113 @default.
- W2770027655 cites W2343795213 @default.
- W2770027655 cites W2396627967 @default.
- W2770027655 cites W2467530578 @default.
- W2770027655 cites W2484646574 @default.
- W2770027655 cites W2951339897 @default.
- W2770027655 cites W4237627879 @default.
- W2770027655 cites W2113075592 @default.
- W2770027655 doi "https://doi.org/10.1111/bjd.16137" @default.
- W2770027655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29150843" @default.
- W2770027655 hasPublicationYear "2018" @default.
- W2770027655 type Work @default.
- W2770027655 sameAs 2770027655 @default.
- W2770027655 citedByCount "12" @default.
- W2770027655 countsByYear W27700276552018 @default.
- W2770027655 countsByYear W27700276552020 @default.
- W2770027655 countsByYear W27700276552021 @default.
- W2770027655 countsByYear W27700276552022 @default.
- W2770027655 countsByYear W27700276552023 @default.
- W2770027655 crossrefType "journal-article" @default.
- W2770027655 hasAuthorship W2770027655A5006023928 @default.
- W2770027655 hasAuthorship W2770027655A5013922423 @default.
- W2770027655 hasAuthorship W2770027655A5015131799 @default.
- W2770027655 hasAuthorship W2770027655A5015975130 @default.
- W2770027655 hasAuthorship W2770027655A5039656288 @default.
- W2770027655 hasAuthorship W2770027655A5049469990 @default.
- W2770027655 hasAuthorship W2770027655A5063262332 @default.
- W2770027655 hasAuthorship W2770027655A5072738641 @default.
- W2770027655 hasAuthorship W2770027655A5072756206 @default.
- W2770027655 hasConcept C142724271 @default.
- W2770027655 hasConcept C16005928 @default.
- W2770027655 hasConcept C203014093 @default.
- W2770027655 hasConcept C2776029263 @default.
- W2770027655 hasConcept C2776914184 @default.
- W2770027655 hasConcept C2780559512 @default.
- W2770027655 hasConcept C2780564577 @default.
- W2770027655 hasConcept C71924100 @default.
- W2770027655 hasConceptScore W2770027655C142724271 @default.
- W2770027655 hasConceptScore W2770027655C16005928 @default.
- W2770027655 hasConceptScore W2770027655C203014093 @default.
- W2770027655 hasConceptScore W2770027655C2776029263 @default.
- W2770027655 hasConceptScore W2770027655C2776914184 @default.
- W2770027655 hasConceptScore W2770027655C2780559512 @default.
- W2770027655 hasConceptScore W2770027655C2780564577 @default.
- W2770027655 hasConceptScore W2770027655C71924100 @default.
- W2770027655 hasIssue "1" @default.
- W2770027655 hasLocation W27700276551 @default.
- W2770027655 hasLocation W27700276552 @default.
- W2770027655 hasLocation W27700276553 @default.