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- W2770109464 abstract "Abstract Myosin VI (MVI) has been found to be overexpressed in ovarian, breast and prostate cancers. Moreover, it has been shown to play a role in regulating cell proliferation and migration, and to interact with RNA Polymerase II (RNAPII). Here, we find that backfolding of MVI regulates its ability to bind DNA and that a putative transcription co-activator NDP52 relieves the auto-inhibition of MVI to enable DNA binding. Additionally, we show that the MVI–NDP52 complex binds RNAPII, which is critical for transcription, and that depletion of NDP52 or MVI reduces steady-state mRNA levels. Lastly, we demonstrate that MVI directly interacts with nuclear receptors to drive expression of target genes, thereby suggesting a link to cell proliferation and migration. Overall, we suggest MVI may function as an auxiliary motor to drive transcription." @default.
- W2770109464 created "2017-12-04" @default.
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- W2770109464 date "2017-11-30" @default.
- W2770109464 modified "2023-09-27" @default.
- W2770109464 title "NDP52 activates nuclear myosin VI to enhance RNA polymerase II transcription" @default.
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- W2770109464 doi "https://doi.org/10.1038/s41467-017-02050-w" @default.
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- W2770109464 hasPublicationYear "2017" @default.
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