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• W2770114085 abstract "Objective . To explore the effect of Ficus deltoidea (FD) aqueous extracts on the release of tumor necrosis factor- α (TNF- α ), the expression of CD40, and the morphology of microglial cells in lipopolysaccharide- (LPS-) activated BV2 cells. Methods . The cytotoxicity of FD extract was assessed by MTS solution. BV2 cells were divided into 5 experimental groups, intervened, respectively, by FD (4 mg/mL) and LPS + FD (0, 1, 2, and 4 mg/mL). Besides, a blank control group was set up without any intervention. TNF- α release was assessed by enzyme linked immunosorbent assay (ELISA). The expression of CD40 was examined by flow cytometry. Immunocytochemical staining was used to show the morphology of BV2 cells. Results . FD extract of different concentrations (1, 2, and 4 mg/mL) had no significant toxic effects on the BV2 cells. FD suppressed the activation of microglia in morphology and reduced TNF- α production and expression of CD40 induced by LPS. Conclusion . FD extract has a therapeutic potential against neuroinflammatory diseases." @default.
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• W2770114085 date "2017-01-01" @default.
• W2770114085 modified "2023-09-28" @default.
• W2770114085 title "Inhibitory Activity ofFicus deltoideavar.trengganuensisAqueous Extract on Lipopolysaccharide-Induced TNF-αProduction from Microglia" @default.
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• W2770114085 doi "https://doi.org/10.1155/2017/2623163" @default.
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