FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2770116848> ?p ?o ?g. }

• W2770116848 endingPage "45" @default.
• W2770116848 startingPage "36" @default.
• W2770116848 abstract "Interferon-&#x03B3; (IFN-&#x03B3;), a cytokine produced by activated natural killer cells and T lymphocytes, is an important regulator of innate and adaptive immunity. Interleukin (IL)-18, also known as IFN-&#x03B3;-inducing factor, is a cytokine that induces T and natural killer cells to produce IFN-&#x03B3;. In this study, the chicken IL-18 (ChIL-18) and chicken IFN-&#x03B3; (ChIFN-&#x03B3;) genes were inserted into the pET28a prokaryotic expression vector, resulting in pET28a-IL-18 and pET28a-IFN-&#x03B3;, respectively. These plasmids were transformed into <i>Escherichia coli </i>strain BL21, and the ChIL-18 and ChIFN-&#x03B3; proteins were expressed and purified. To determine their antiviral activities, 200 ng/mL of ChIL-18 and/or ChIFN-&#x03B3; were inoculated into chicken embryonic fibroblast cells. After 24 h, one 50% tissue culture infective dose (TCID₅₀) of infectious bursal disease virus (IBDV) was inoculated into the chicken embryonic fibroblast cells. The results showed that the antiviral effect of ChIL-18 and ChIFN-&#x03B3; in combination was better than that of ChIL-18 or ChIFN-&#x03B3; alone. Next, 14-day-old chicken were injected with 200 µg of ChIL-18 and/or ChIFN-&#x03B3; and then were challenged with 10³ TCID₅₀ of IBDV via intraperitoneal injection. The results showed that the proliferation of IBDV was inhibited by the injection of the recombinant proteins, especially the combination of ChIL-18 and ChIFN-&#x03B3;, as evidenced by cytokine detection, quantitative PCR, and pathology analyses. These results indicate that ChIL-18 and ChIFN-&#x03B3; could inhibit IBDV infection and the combination of ChIL-18 and ChIFN-&#x03B3; has a better inhibitory effect than either cytokine alone." @default.
• W2770116848 created "2017-12-04" @default.
• W2770116848 creator A5008379025 @default.
• W2770116848 creator A5010903174 @default.
• W2770116848 creator A5020842489 @default.
• W2770116848 creator A5022146107 @default.
• W2770116848 creator A5064408814 @default.
• W2770116848 creator A5070198062 @default.
• W2770116848 creator A5078677061 @default.
• W2770116848 date "2017-01-01" @default.
• W2770116848 modified "2023-09-23" @default.
• W2770116848 title "Prokaryotic Expression and Anti-IBDV Activity of Chicken Interleukin-18 and Interferon-γ" @default.
• W2770116848 cites W1447793845 @default.
• W2770116848 cites W1936525329 @default.
• W2770116848 cites W1974894998 @default.
• W2770116848 cites W1975275088 @default.
• W2770116848 cites W1988010070 @default.
• W2770116848 cites W1997846882 @default.
• W2770116848 cites W1998624755 @default.
• W2770116848 cites W2001805584 @default.
• W2770116848 cites W2037299986 @default.
• W2770116848 cites W2043956422 @default.
• W2770116848 cites W2049902812 @default.
• W2770116848 cites W2051848005 @default.
• W2770116848 cites W2064856766 @default.
• W2770116848 cites W2070340931 @default.
• W2770116848 cites W2075482744 @default.
• W2770116848 cites W2082150927 @default.
• W2770116848 cites W2091359985 @default.
• W2770116848 cites W2111831404 @default.
• W2770116848 cites W2116389925 @default.
• W2770116848 cites W2127004170 @default.
• W2770116848 cites W2134768631 @default.
• W2770116848 cites W2135090436 @default.
• W2770116848 cites W2155996840 @default.
• W2770116848 cites W2165872472 @default.
• W2770116848 cites W2166454467 @default.
• W2770116848 cites W2168572535 @default.
• W2770116848 cites W2171831396 @default.
• W2770116848 cites W2175122451 @default.
• W2770116848 cites W2272979264 @default.
• W2770116848 cites W2302444540 @default.
• W2770116848 cites W2464020216 @default.
• W2770116848 cites W2510181898 @default.
• W2770116848 cites W2511927825 @default.
• W2770116848 cites W561470261 @default.
• W2770116848 cites W652849519 @default.
• W2770116848 doi "https://doi.org/10.1159/000481522" @default.
• W2770116848 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29169149" @default.
• W2770116848 hasPublicationYear "2017" @default.
• W2770116848 type Work @default.
• W2770116848 sameAs 2770116848 @default.
• W2770116848 citedByCount "5" @default.
• W2770116848 countsByYear W27701168482019 @default.
• W2770116848 countsByYear W27701168482020 @default.
• W2770116848 countsByYear W27701168482021 @default.
• W2770116848 crossrefType "journal-article" @default.
• W2770116848 hasAuthorship W2770116848A5008379025 @default.
• W2770116848 hasAuthorship W2770116848A5010903174 @default.
• W2770116848 hasAuthorship W2770116848A5020842489 @default.
• W2770116848 hasAuthorship W2770116848A5022146107 @default.
• W2770116848 hasAuthorship W2770116848A5064408814 @default.
• W2770116848 hasAuthorship W2770116848A5070198062 @default.
• W2770116848 hasAuthorship W2770116848A5078677061 @default.
• W2770116848 hasConcept C104317684 @default.
• W2770116848 hasConcept C153911025 @default.
• W2770116848 hasConcept C159047783 @default.
• W2770116848 hasConcept C203014093 @default.
• W2770116848 hasConcept C22744801 @default.
• W2770116848 hasConcept C2522874641 @default.
• W2770116848 hasConcept C2776178377 @default.
• W2770116848 hasConcept C2777810641 @default.
• W2770116848 hasConcept C2778690821 @default.
• W2770116848 hasConcept C55493867 @default.
• W2770116848 hasConcept C60987743 @default.
• W2770116848 hasConcept C86803240 @default.
• W2770116848 hasConceptScore W2770116848C104317684 @default.
• W2770116848 hasConceptScore W2770116848C153911025 @default.
• W2770116848 hasConceptScore W2770116848C159047783 @default.
• W2770116848 hasConceptScore W2770116848C203014093 @default.
• W2770116848 hasConceptScore W2770116848C22744801 @default.
• W2770116848 hasConceptScore W2770116848C2522874641 @default.
• W2770116848 hasConceptScore W2770116848C2776178377 @default.
• W2770116848 hasConceptScore W2770116848C2777810641 @default.
• W2770116848 hasConceptScore W2770116848C2778690821 @default.
• W2770116848 hasConceptScore W2770116848C55493867 @default.
• W2770116848 hasConceptScore W2770116848C60987743 @default.
• W2770116848 hasConceptScore W2770116848C86803240 @default.
• W2770116848 hasIssue "1" @default.
• W2770116848 hasLocation W27701168481 @default.
• W2770116848 hasLocation W27701168482 @default.
• W2770116848 hasOpenAccess W2770116848 @default.
• W2770116848 hasPrimaryLocation W27701168481 @default.
• W2770116848 hasRelatedWork W1994878443 @default.
• W2770116848 hasRelatedWork W1996876935 @default.
• W2770116848 hasRelatedWork W2006312942 @default.
• W2770116848 hasRelatedWork W2024917435 @default.
• W2770116848 hasRelatedWork W2042835129 @default.

• next