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• W2770128744 abstract "Mitosis-specific role of ATR The ATR (ataxia telangiectasia mutated and Rad3-related) kinase plays important roles in the S phase and during the DNA damage response to safeguard genome integrity. Kabeche et al. identified a distinct ATR activation pathway in mitosis that is also critical for suppressing genome instability (see the Perspective by Saldivar and Cimprich). ATR is recruited by Aurora A and activated by R loops at centromeres of mitotic chromosomes; this leads to Aurora B activation, which is necessary for accurate chromosome segregation. This mitotic, R loop–driven ATR signaling pathway could potentially be exploited in the search for cancer therapeutics. Science , this issue p. 108 ; see also p. 30" @default.
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• W2770128744 date "2018-01-05" @default.
• W2770128744 modified "2023-10-15" @default.
• W2770128744 title "A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation" @default.
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• W2770128744 doi "https://doi.org/10.1126/science.aan6490" @default.
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