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- W2770136100 abstract "Abstract Background: Different components of the endogenous cannabinoid system (ECS) affect responses to drugs of abuse such as alcohol, nicotine, opioids, psychostimulants, and cannabinoids. Overview: This chapter summarizes the preclinical findings obtained across substances with a focus on drug-taking and drug-seeking behaviors. Focus will be on pharmacological approaches modulating cannabinoid CB1 and CB2 receptors and the endocannabinoid tone [changing levels of anandamide and 2-arachidonoylglycerol (2-AG)]. Conclusion: The CB1 receptor plays an important role in modulating drug-seeking behaviors for all substances of abuse studied. There is also a clear impact of CB1 in mediating drug taking for several drugs of abuse, with the notable exception of psychostimulant drug. The role of CB2 receptor is still unclear and warrants further exploration. Elevation of anandamide appears to reduce drug-seeking behaviors, although too few studies have explored the role of 2-AG. Different existent ways of modulating the ECS could lead to effective therapeutic strategies for addiction lacking the undesirable psychiatric side effects previously associated with CB1 inverse agonists/antagonists." @default.
- W2770136100 created "2017-12-04" @default.
- W2770136100 creator A5027044666 @default.
- W2770136100 creator A5062111870 @default.
- W2770136100 date "2017-01-01" @default.
- W2770136100 modified "2023-09-28" @default.
- W2770136100 title "The Role of the Endocannabinoid System in Addiction" @default.
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