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• W2770197657 abstract "The present study examined how systemic low doses of nicotine affect the microstructure of reinforced food-seeking behavior in rats. Rats were first given an acute saline or nicotine treatment (0.1–0.6 mg/kg, with an inter-injection interval of at least 48 h), and then a chronic saline or nicotine treatment (0.3 mg/kg/day for 10 consecutive days). Immediately after each injection, rats were required to press a lever five times to obtain food that was available at unpredictable times (on average every 80 s) with constant probability. Acute nicotine dose-dependently suppressed behavior prior to the delivery of the first reinforcer, but enhanced food-reinforced behavior afterwards. These effects were primarily observed in the time it took rats to initiate food-seeking behavior. Enhancing effects were also observed in the microstructure of food-seeking behavior, with lower nicotine doses (0.1–0.3 mg/kg) increasing the rate at which response bouts were initiated, and higher doses (0.3–0.6 mg/kg) increasing within-bout response rates. A pre-feeding control suggests that changes in appetite alone cannot explain these effects. Over the course of chronic nicotine exposure, tolerance developed to the suppressive, but not to the enhancing effects of nicotine on food-seeking behavior. These results suggest that (a) lower doses of nicotine enhance the reward value of food and/or food-associated stimuli, (b) higher doses of nicotine enhance motoric activity, and (c) ostensive sensitization effects of nicotine on behavior partially reflect a tolerance to its transient suppressive motoric effects." @default.
• W2770197657 created "2017-12-04" @default.
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• W2770197657 date "2018-02-01" @default.
• W2770197657 modified "2023-09-24" @default.
• W2770197657 title "Suppressive and enhancing effects of nicotine on food-seeking behavior" @default.
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• W2770197657 doi "https://doi.org/10.1016/j.bbr.2017.11.023" @default.
• W2770197657 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5736011" @default.
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