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- W2770295569 abstract "Early adversity in childhood increases the risk of anxiety, mood, and post-traumatic stress disorders in adulthood, and specific gene-by-environment interactions may increase risk further. A common functional variant in the promoter region of the gene encoding the human MET receptor tyrosine kinase (rs1858830 ‘C’ allele) reduces expression of MET and is associated with altered cortical circuit function and structural connectivity. Mice with reduced Met expression exhibit changes in anxiety-like and conditioned fear behavior, precocious synaptic maturation in the hippocampus, and reduced neuronal arbor complexity and synaptogenesis. These phenotypes also can be produced independently by early adversity in wild-type mice. The present study addresses the outcome of combining early-life stress and genetic influences that alter timing of maturation on enduring functional and structural phenotypes. Using a model of reduced Met expression (Met+/−) and early-life stress from postnatal day 2–9, social, anxiety-like, and contextual fear behaviors in later life were measured. Mice that experienced early-life stress exhibited impairments in social interaction, whereas alterations in anxiety-like behavior and fear learning were driven by Met haploinsufficiency, independent of rearing condition. Early-life stress or reduced Met expression decreased arbor complexity of ventral hippocampal CA1 pyramidal neurons projecting to basolateral amygdala. Paradoxically, arbor complexity in Met+/− mice was increased following early-life stress, and thus not different from arbors in wild-type mice raised in control conditions. The changes in dendritic morphology are consistent with the hypothesis that the physiological state of maturation of CA1 neurons in Met+/− mice influences their responsiveness to early-life stress. The dissociation of behavioral and structural changes suggests that there may be phenotype-specific sensitivities to early-life stress." @default.
- W2770295569 created "2017-12-04" @default.
- W2770295569 creator A5039497420 @default.
- W2770295569 creator A5041102654 @default.
- W2770295569 date "2018-02-01" @default.
- W2770295569 modified "2023-10-17" @default.
- W2770295569 title "Differential impact of Met receptor gene interaction with early-life stress on neuronal morphology and behavior in mice" @default.
- W2770295569 cites W1601515225 @default.
- W2770295569 cites W1620047260 @default.
- W2770295569 cites W1711578039 @default.
- W2770295569 cites W1722355893 @default.
- W2770295569 cites W1774350554 @default.
- W2770295569 cites W1796519617 @default.
- W2770295569 cites W1812131700 @default.
- W2770295569 cites W1898548043 @default.
- W2770295569 cites W1944272128 @default.
- W2770295569 cites W1968652954 @default.
- W2770295569 cites W1970882922 @default.
- W2770295569 cites W1972487453 @default.
- W2770295569 cites W1972646149 @default.
- W2770295569 cites W1977497843 @default.
- W2770295569 cites W1979622085 @default.
- W2770295569 cites W1979990721 @default.
- W2770295569 cites W1983784678 @default.
- W2770295569 cites W1985661446 @default.
- W2770295569 cites W1988059569 @default.
- W2770295569 cites W1988125482 @default.
- W2770295569 cites W1990366708 @default.
- W2770295569 cites W1991422316 @default.
- W2770295569 cites W1995647101 @default.
- W2770295569 cites W1997982013 @default.
- W2770295569 cites W1998980503 @default.
- W2770295569 cites W2004738185 @default.
- W2770295569 cites W2012948493 @default.
- W2770295569 cites W2015629767 @default.
- W2770295569 cites W2020553975 @default.
- W2770295569 cites W2022682055 @default.
- W2770295569 cites W2023144165 @default.
- W2770295569 cites W2024392432 @default.
- W2770295569 cites W2035910639 @default.
- W2770295569 cites W2042125519 @default.
- W2770295569 cites W2045906221 @default.
- W2770295569 cites W2046998806 @default.
- W2770295569 cites W2050959523 @default.
- W2770295569 cites W2053061904 @default.
- W2770295569 cites W2053924129 @default.
- W2770295569 cites W2057632757 @default.
- W2770295569 cites W2063400326 @default.
- W2770295569 cites W2065418093 @default.
- W2770295569 cites W2069588969 @default.
- W2770295569 cites W2070595385 @default.
- W2770295569 cites W2071654165 @default.
- W2770295569 cites W2080030919 @default.
- W2770295569 cites W2080496806 @default.
- W2770295569 cites W2081040817 @default.
- W2770295569 cites W2087921594 @default.
- W2770295569 cites W2088592332 @default.
- W2770295569 cites W2089112861 @default.
- W2770295569 cites W2090762968 @default.
- W2770295569 cites W2093577458 @default.
- W2770295569 cites W2094549516 @default.
- W2770295569 cites W2099384073 @default.
- W2770295569 cites W2100086239 @default.
- W2770295569 cites W2105394148 @default.
- W2770295569 cites W2114350859 @default.
- W2770295569 cites W2116116525 @default.
- W2770295569 cites W2117055846 @default.
- W2770295569 cites W2118109922 @default.
- W2770295569 cites W2120260765 @default.
- W2770295569 cites W2121055235 @default.
- W2770295569 cites W2127554180 @default.
- W2770295569 cites W2131073955 @default.
- W2770295569 cites W2132695255 @default.
- W2770295569 cites W2135828915 @default.
- W2770295569 cites W2137787353 @default.
- W2770295569 cites W2140660757 @default.
- W2770295569 cites W2142364482 @default.
- W2770295569 cites W2142958591 @default.
- W2770295569 cites W2150328639 @default.
- W2770295569 cites W2153136574 @default.
- W2770295569 cites W2153805137 @default.
- W2770295569 cites W2154629684 @default.
- W2770295569 cites W2154889913 @default.
- W2770295569 cites W2161944843 @default.
- W2770295569 cites W2169629289 @default.
- W2770295569 cites W2171217262 @default.
- W2770295569 cites W2190061239 @default.
- W2770295569 cites W2223839472 @default.
- W2770295569 cites W2235598935 @default.
- W2770295569 cites W2254443919 @default.
- W2770295569 cites W2262331975 @default.
- W2770295569 cites W2264061658 @default.
- W2770295569 cites W2265810207 @default.
- W2770295569 cites W2267699473 @default.
- W2770295569 cites W2279313673 @default.
- W2770295569 cites W2281334703 @default.
- W2770295569 cites W2290790382 @default.
- W2770295569 cites W2330560746 @default.