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• W2770295769 abstract "Objective Treatment selection for recurrent ovarian cancer is typically based on the duration of time between the completion of adjuvant, platinum-based therapy and the time of recurrence, the platinum free interval (PFI). We examined the use of, and outcomes associated with platinum-based chemotherapy based on the PFI in women with recurrent ovarian cancer. Methods The Surveillance, Epidemiology, and End Results-Medicare database was used to identify women aged >65 years with epithelial ovarian cancer who underwent surgery and platinum-based chemotherapy and who developed a recurrence >3 months after the completion of adjuvant therapy. Patients were stratified by PFI into 3 groups: PFI <6 months, PFI 7–12 months, and PFI >12 months. Multivariable models were used to examine predictors of use of platinum-based therapy and survival for each group. Results A total of 2369 patients were identified. In women with a PFI of ≤6 months, treatment consisted of platinum-based combination therapy in 28.2%, single agent platinum in 5.2% and non-platinum therapy in 66.6%. Corresponding rates of these treatments among women with a PFI of 7–12 months were 39.7%, 12.4% and 47.9%, respectively; the rates were 57.6%, 13.2% and 29.3% in those with a PFI of >12 months, respectively. Median survival was 13, 18, and 27 months for patients with a PFI of ≤6 months, 7–12 months, and >12 months, respectively (P < 0.0001). For all three groups, platinum combination therapy was associated with decreased risk of death compared to non‑platinum based therapy. Conclusion Platinum free interval is a strong predictor of survival in elderly women with recurrent ovarian cancer. There is widespread variation in treatment selection for women with recurrent ovarian cancer with many women receiving non-guideline based regimens." @default.
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• W2770295769 date "2018-01-01" @default.
• W2770295769 modified "2023-10-16" @default.
• W2770295769 title "Adherence to treatment recommendations and outcomes for women with ovarian cancer at first recurrence" @default.
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• W2770295769 doi "https://doi.org/10.1016/j.ygyno.2017.11.008" @default.
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