FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2770298413> ?p ?o ?g. }

• W2770298413 abstract "The thesis is concerned with the synthesis and characterization of cell-interacting biomaterials produced from natural polymers, in particular chitosan and DNA, for their potential use as scaffolds for bone regeneration in the treatment of periodontal lesions presenting advanced bone damage. The biomaterials were shaped to present 2D (membranes) and 3D configurations (pearls) in order to develop potentially complementary tools to be applied alone or simultaneously at different spatial locations of the periodontal system.On the one hand, 2D membranes were synthesized by solvent casting followed by surface-crosslinking and rationalized to be implanted between the damaged alveolar bone and the gingiva, in close contact with the gingival connective tissue. At this particular location and thanks to the implemented surface treatment, the membranes are envisaged to carry out two main functions important to bone regeneration. First, they were tailored to promote the adhesion and proliferation of osteoblast cells by one of their surfaces (that pointing to the alveolar region). Second, and by virtue of their selective surface modification, once implanted the membranes are also anticipated to act as a physical barrier between the alveolar bone and the gingiva so as to avoid the migration of gingival cells to the bone compartment, as typically practiced in Guided Tissue Regeneration (GTR) strategies.On the other hand, cell-laden 3D pearls were synthesized by UV-light mediated crosslinking on top of superhydrophobic surfaces and rationalized to be implanted directly to the damaged alveolar region, underneath the membranes, where voids characteristic of periodontitis take place as a result of bone destruction. At this deeper location (close to the root), the 3D pearls are expected to avoid membrane collapse inside the defect due to the soft tissue pressure during the healing process and promote the bone tissue regeneration upon release and proliferation of encapsulated cells. Important to both purposes, and thanks to their a core-shell architecture, the cell-laden pearls here produced proved to display (i) an outstanding structural stability for their practical handling and easy implantation and (ii) a necessary capability to release viable osteoblast cells once in contact with simulated body fluids (cell culture media).To prove their suitability for the tentative proposed applications, the biomaterials were characterized in terms of their chemical, mechanical, and biological properties by means of a battery of experimental techniques. Primary methods included Nuclear Magnetic Resonance spectroscopy (NMR), Fourier Transform Infrared spectroscopy (FT-IR), Atomic Force Microscopy (AFM), Mechanical Puncture Assays, Optical and Confocal Microscopy, Cell Culture, Water Contact Angle Measurements (WCA), and different Enzyme-Linked Immunosorbent Assays (ELISA). Basic synthetic procedures included Chemical Vapor Deposition and grafting polymerization mediated by a liquid-phase methacrylation reaction." @default.
• W2770298413 created "2017-12-04" @default.
• W2770298413 creator A5018896616 @default.
• W2770298413 date "2016-01-01" @default.
• W2770298413 modified "2023-09-26" @default.
• W2770298413 title "2D and 3D biomaterials produced from natural polymers with potential applications for bone regeneration in the treatment of periodontal lesions" @default.
• W2770298413 hasPublicationYear "2016" @default.
• W2770298413 type Work @default.
• W2770298413 sameAs 2770298413 @default.
• W2770298413 citedByCount "0" @default.
• W2770298413 crossrefType "journal-article" @default.
• W2770298413 hasAuthorship W2770298413A5018896616 @default.
• W2770298413 hasConcept C136229726 @default.
• W2770298413 hasConcept C142724271 @default.
• W2770298413 hasConcept C151279780 @default.
• W2770298413 hasConcept C159985019 @default.
• W2770298413 hasConcept C171056886 @default.
• W2770298413 hasConcept C185592680 @default.
• W2770298413 hasConcept C192562407 @default.
• W2770298413 hasConcept C199343813 @default.
• W2770298413 hasConcept C2778606738 @default.
• W2770298413 hasConcept C41625074 @default.
• W2770298413 hasConcept C41868710 @default.
• W2770298413 hasConcept C518705261 @default.
• W2770298413 hasConcept C55493867 @default.
• W2770298413 hasConcept C71924100 @default.
• W2770298413 hasConcept C84416704 @default.
• W2770298413 hasConcept C86803240 @default.
• W2770298413 hasConcept C95444343 @default.
• W2770298413 hasConceptScore W2770298413C136229726 @default.
• W2770298413 hasConceptScore W2770298413C142724271 @default.
• W2770298413 hasConceptScore W2770298413C151279780 @default.
• W2770298413 hasConceptScore W2770298413C159985019 @default.
• W2770298413 hasConceptScore W2770298413C171056886 @default.
• W2770298413 hasConceptScore W2770298413C185592680 @default.
• W2770298413 hasConceptScore W2770298413C192562407 @default.
• W2770298413 hasConceptScore W2770298413C199343813 @default.
• W2770298413 hasConceptScore W2770298413C2778606738 @default.
• W2770298413 hasConceptScore W2770298413C41625074 @default.
• W2770298413 hasConceptScore W2770298413C41868710 @default.
• W2770298413 hasConceptScore W2770298413C518705261 @default.
• W2770298413 hasConceptScore W2770298413C55493867 @default.
• W2770298413 hasConceptScore W2770298413C71924100 @default.
• W2770298413 hasConceptScore W2770298413C84416704 @default.
• W2770298413 hasConceptScore W2770298413C86803240 @default.
• W2770298413 hasConceptScore W2770298413C95444343 @default.
• W2770298413 hasLocation W27702984131 @default.
• W2770298413 hasOpenAccess W2770298413 @default.
• W2770298413 hasPrimaryLocation W27702984131 @default.
• W2770298413 hasRelatedWork W1975451456 @default.
• W2770298413 hasRelatedWork W1986951341 @default.
• W2770298413 hasRelatedWork W2030422796 @default.
• W2770298413 hasRelatedWork W2040955859 @default.
• W2770298413 hasRelatedWork W2050343055 @default.
• W2770298413 hasRelatedWork W2072675987 @default.
• W2770298413 hasRelatedWork W2079584071 @default.
• W2770298413 hasRelatedWork W2121067200 @default.
• W2770298413 hasRelatedWork W2154745340 @default.
• W2770298413 hasRelatedWork W2292048715 @default.
• W2770298413 hasRelatedWork W2401958041 @default.
• W2770298413 hasRelatedWork W2412497287 @default.
• W2770298413 hasRelatedWork W2418247831 @default.
• W2770298413 hasRelatedWork W2543200880 @default.
• W2770298413 hasRelatedWork W2590663286 @default.
• W2770298413 hasRelatedWork W2908856154 @default.
• W2770298413 hasRelatedWork W2968798941 @default.
• W2770298413 hasRelatedWork W2969104547 @default.
• W2770298413 hasRelatedWork W3097508668 @default.
• W2770298413 hasRelatedWork W2814554330 @default.
• W2770298413 isParatext "false" @default.
• W2770298413 isRetracted "false" @default.
• W2770298413 magId "2770298413" @default.
• W2770298413 workType "article" @default.