Matches in SemOpenAlex for { <https://semopenalex.org/work/W2770300040> ?p ?o ?g. }
- W2770300040 abstract "Harnessing the matrix topography as biophysical cues has shown to control various cellular organizations, including cell adhesion, proliferation, alignment, and differentiation of stem cells. However, recapitulating topographical and spatial cues in engineering skeletal muscle tissues using human embryonic stem cells (hESCs) remains a challenge. Here, such topographical cues are created by employing the soft lithography techniques to promote topographical cues-guided in vitro myogenic commitment of hESCs. Our findings indicate that hESC- derived myogenic progenitors cells cultured on micropatterned PDMS cell culture substrates could significantly mimic the hierarchically organized characteristics of myoblasts, as evident from their ability to form highly aligned multinucleated myotubes. Myogenic commitment of stem cells could possibly be achieved through the topographical cues-guided actin cytoskeleton changes and their consequent cellular alignment, which promoted the fusion of hESC-derived myogenic progenitors to form multinucleated myotubes. The results described in this study provide a proof-of- principle that matrix topology could effectively control stem cell fate by modulating cell-matrix interaction" @default.
- W2770300040 created "2017-12-04" @default.
- W2770300040 creator A5009883706 @default.
- W2770300040 date "2015-01-01" @default.
- W2770300040 modified "2023-09-27" @default.
- W2770300040 title "Topographical cues-guided myogenic differentiation of human embryonic stem cells" @default.
- W2770300040 cites W1588475636 @default.
- W2770300040 cites W1590619267 @default.
- W2770300040 cites W1967533329 @default.
- W2770300040 cites W1967566401 @default.
- W2770300040 cites W1969181065 @default.
- W2770300040 cites W1973403961 @default.
- W2770300040 cites W1978927129 @default.
- W2770300040 cites W1979009272 @default.
- W2770300040 cites W1979208678 @default.
- W2770300040 cites W1981777800 @default.
- W2770300040 cites W1982292079 @default.
- W2770300040 cites W1986864448 @default.
- W2770300040 cites W1987680648 @default.
- W2770300040 cites W1989923134 @default.
- W2770300040 cites W1993326869 @default.
- W2770300040 cites W1995959676 @default.
- W2770300040 cites W1999666701 @default.
- W2770300040 cites W2003064100 @default.
- W2770300040 cites W2005106455 @default.
- W2770300040 cites W2005111784 @default.
- W2770300040 cites W2007942167 @default.
- W2770300040 cites W2021440286 @default.
- W2770300040 cites W2036326354 @default.
- W2770300040 cites W2038512674 @default.
- W2770300040 cites W2043126651 @default.
- W2770300040 cites W2043354767 @default.
- W2770300040 cites W2044921290 @default.
- W2770300040 cites W2048820537 @default.
- W2770300040 cites W2049094551 @default.
- W2770300040 cites W2051076903 @default.
- W2770300040 cites W2052318709 @default.
- W2770300040 cites W2055239373 @default.
- W2770300040 cites W2057072817 @default.
- W2770300040 cites W2058096164 @default.
- W2770300040 cites W2060677662 @default.
- W2770300040 cites W2061981400 @default.
- W2770300040 cites W2065128345 @default.
- W2770300040 cites W2069295991 @default.
- W2770300040 cites W2070633960 @default.
- W2770300040 cites W2073523882 @default.
- W2770300040 cites W2078361300 @default.
- W2770300040 cites W2078741183 @default.
- W2770300040 cites W2086943348 @default.
- W2770300040 cites W2088686740 @default.
- W2770300040 cites W2093569973 @default.
- W2770300040 cites W2094087897 @default.
- W2770300040 cites W2094107076 @default.
- W2770300040 cites W2096885081 @default.
- W2770300040 cites W2100250587 @default.
- W2770300040 cites W2103274097 @default.
- W2770300040 cites W2107277218 @default.
- W2770300040 cites W2108674983 @default.
- W2770300040 cites W2110448418 @default.
- W2770300040 cites W2110839189 @default.
- W2770300040 cites W2111023797 @default.
- W2770300040 cites W2113371601 @default.
- W2770300040 cites W2123207426 @default.
- W2770300040 cites W2129784802 @default.
- W2770300040 cites W2131333364 @default.
- W2770300040 cites W2134110690 @default.
- W2770300040 cites W2135073071 @default.
- W2770300040 cites W2135738344 @default.
- W2770300040 cites W2138896629 @default.
- W2770300040 cites W2139973886 @default.
- W2770300040 cites W2141163297 @default.
- W2770300040 cites W2144023435 @default.
- W2770300040 cites W2145444336 @default.
- W2770300040 cites W2147280563 @default.
- W2770300040 cites W2154041187 @default.
- W2770300040 cites W2157767776 @default.
- W2770300040 cites W2158048826 @default.
- W2770300040 cites W2161768378 @default.
- W2770300040 cites W2171546618 @default.
- W2770300040 cites W2172160601 @default.
- W2770300040 cites W2173288619 @default.
- W2770300040 cites W2588514930 @default.
- W2770300040 cites W5410578 @default.
- W2770300040 cites W58326483 @default.
- W2770300040 cites W2134560161 @default.
- W2770300040 hasPublicationYear "2015" @default.
- W2770300040 type Work @default.
- W2770300040 sameAs 2770300040 @default.
- W2770300040 citedByCount "0" @default.
- W2770300040 crossrefType "journal-article" @default.
- W2770300040 hasAuthorship W2770300040A5009883706 @default.
- W2770300040 hasConcept C104317684 @default.
- W2770300040 hasConcept C105702510 @default.
- W2770300040 hasConcept C136403682 @default.
- W2770300040 hasConcept C145103041 @default.
- W2770300040 hasConcept C148738053 @default.
- W2770300040 hasConcept C189165786 @default.
- W2770300040 hasConcept C201750760 @default.
- W2770300040 hasConcept C207200792 @default.
- W2770300040 hasConcept C28328180 @default.