FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2770337890> ?p ?o ?g. }

• W2770337890 endingPage "841" @default.
• W2770337890 startingPage "825" @default.
• W2770337890 abstract "Spinal cord injury (SCI) results in lesions that destroy tissue and disrupt spinal tracts, producing deficits in locomotor and autonomic function. We previously demonstrated that motoneurons and the muscles they innervate show pronounced atrophy after SCI, and these changes are prevented by treatment with testosterone. Here, we assessed whether the testosterone active metabolites estradiol and dihydrotestosterone have similar protective effects after SCI. Young adult female rats received either sham or T9 spinal cord contusion injuries and were treated with estradiol, dihydrotestosterone, both, or nothing via Silastic capsules. Basso-Beattie-Bresnahan locomotor testing was performed weekly and voiding behavior was assessed at 3 weeks post-injury. Four weeks after SCI, lesion volume and tissue sparing, quadriceps muscle fiber cross-sectional area, and motoneuron dendritic morphology were assessed. Spontaneous locomotor behavior improved after SCI, but hormone treatments had no effect. Voiding behavior was disrupted after SCI, but was significantly improved by treatment with either estradiol or dihydrotestosterone; combined treatment was maximally effective. Treatment with estradiol reduced lesion volume, but dihydrotestosterone alone and estradiol combined with dihydrotestosterone were ineffective. SCI-induced decreases in motoneuron dendritic length were attenuated by all hormone treatments. SCI-induced reductions in muscle fiber cross-sectional areas were prevented by treatment with either dihydrotestosterone or estradiol combined with dihydrotestosterone, but estradiol treatment was ineffective. These findings suggest that deficits in micturition and regressive changes in motoneuron and muscle morphology seen after SCI are ameliorated by treatment with estradiol or dihydrotestosterone, further supporting a role for steroid hormones as neurotherapeutic agents in the injured nervous system." @default.
• W2770337890 created "2017-12-04" @default.
• W2770337890 creator A5000449197 @default.
• W2770337890 creator A5002657140 @default.
• W2770337890 creator A5017677048 @default.
• W2770337890 creator A5028896534 @default.
• W2770337890 creator A5044547233 @default.
• W2770337890 creator A5068298345 @default.
• W2770337890 creator A5091652696 @default.
• W2770337890 date "2018-03-15" @default.
• W2770337890 modified "2023-09-27" @default.
• W2770337890 title "Protective Effects of Estradiol and Dihydrotestosterone following Spinal Cord Injury" @default.
• W2770337890 cites W1425165754 @default.
• W2770337890 cites W1482711476 @default.
• W2770337890 cites W1513993635 @default.
• W2770337890 cites W1571949671 @default.
• W2770337890 cites W165013554 @default.
• W2770337890 cites W1907724378 @default.
• W2770337890 cites W1936093460 @default.
• W2770337890 cites W1962420039 @default.
• W2770337890 cites W1963537677 @default.
• W2770337890 cites W1964726243 @default.
• W2770337890 cites W1965192311 @default.
• W2770337890 cites W1965283193 @default.
• W2770337890 cites W1965795866 @default.
• W2770337890 cites W1965829756 @default.
• W2770337890 cites W1966457685 @default.
• W2770337890 cites W1967973544 @default.
• W2770337890 cites W1968534173 @default.
• W2770337890 cites W1968588589 @default.
• W2770337890 cites W1969912167 @default.
• W2770337890 cites W1970313313 @default.
• W2770337890 cites W1971713732 @default.
• W2770337890 cites W1972763499 @default.
• W2770337890 cites W1973124350 @default.
• W2770337890 cites W1974638429 @default.
• W2770337890 cites W1975970556 @default.
• W2770337890 cites W1976173583 @default.
• W2770337890 cites W1976398459 @default.
• W2770337890 cites W1977088787 @default.
• W2770337890 cites W1977309548 @default.
• W2770337890 cites W1977571517 @default.
• W2770337890 cites W1978302335 @default.
• W2770337890 cites W1980628066 @default.
• W2770337890 cites W1982604228 @default.
• W2770337890 cites W1982839897 @default.
• W2770337890 cites W1983285229 @default.
• W2770337890 cites W1985308391 @default.
• W2770337890 cites W1986574486 @default.
• W2770337890 cites W1990669417 @default.
• W2770337890 cites W1994208027 @default.
• W2770337890 cites W1994304262 @default.
• W2770337890 cites W1998059793 @default.
• W2770337890 cites W1998152179 @default.
• W2770337890 cites W1999607066 @default.
• W2770337890 cites W2002406661 @default.
• W2770337890 cites W2004272415 @default.
• W2770337890 cites W2004832777 @default.
• W2770337890 cites W2005072972 @default.
• W2770337890 cites W2005333476 @default.
• W2770337890 cites W2006268333 @default.
• W2770337890 cites W2008969125 @default.
• W2770337890 cites W2009206885 @default.
• W2770337890 cites W2012169853 @default.
• W2770337890 cites W2015066890 @default.
• W2770337890 cites W2017172012 @default.
• W2770337890 cites W2017525596 @default.
• W2770337890 cites W2019599063 @default.
• W2770337890 cites W2020708527 @default.
• W2770337890 cites W2022288630 @default.
• W2770337890 cites W2022315433 @default.
• W2770337890 cites W2030948818 @default.
• W2770337890 cites W2033024884 @default.
• W2770337890 cites W2034175214 @default.
• W2770337890 cites W2035521605 @default.
• W2770337890 cites W2035761264 @default.
• W2770337890 cites W2040561275 @default.
• W2770337890 cites W2044167233 @default.
• W2770337890 cites W2046834163 @default.
• W2770337890 cites W2048419965 @default.
• W2770337890 cites W2049123976 @default.
• W2770337890 cites W2050410777 @default.
• W2770337890 cites W2050517301 @default.
• W2770337890 cites W2052338477 @default.
• W2770337890 cites W2052977045 @default.
• W2770337890 cites W2053375568 @default.
• W2770337890 cites W2053853368 @default.
• W2770337890 cites W2055919993 @default.
• W2770337890 cites W2056673548 @default.
• W2770337890 cites W2057861156 @default.
• W2770337890 cites W2062999076 @default.
• W2770337890 cites W2063046277 @default.
• W2770337890 cites W2064057862 @default.
• W2770337890 cites W2064066068 @default.
• W2770337890 cites W2064963699 @default.
• W2770337890 cites W2066106883 @default.
• W2770337890 cites W2067435357 @default.
• W2770337890 cites W2068091820 @default.

• next