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• W2770374950 endingPage "e0005877" @default.
• W2770374950 startingPage "e0005877" @default.
• W2770374950 abstract "Background The South-East Asia Region Kala-azar Elimination Programme (KAEP) is expected to enter the consolidation phase in 2017, which focuses on case detection, vector control, and identifying potential sources of infection. Post-kala-azar dermal leishmaniasis (PKDL) is thought to play a role in the recurrence of visceral leishmaniasis (VL)/kala-azar outbreaks, and control of PKDL is among the priorities of the KAEP. Methodology and principal finding We reviewed the literature with regard to PKDL in Asia and interpreted the findings in relation to current intervention methods in the KAEP in order to make recommendations. There is a considerable knowledge gap regarding the pathophysiology of VL and PKDL, especially the underlying immune responses. Risk factors (of which previous VL treatments may be most important) are poorly understood and need to be better defined. The role of PKDL patients in transmission is largely unknown, and there is insufficient information about the importance of duration, distribution and severity of the rash, time of onset, and self-healing. Current intervention methods focus on active case detection and treatment of all PKDL cases with miltefosine while there is increasing drug resistance. The prevention of PKDL by improved VL treatment currently receives insufficient attention. Conclusion and significance PKDL is a heterogeneous and dynamic condition, and patients differ with regard to time of onset after VL, chronicity, and distribution and appearance of the rash, as well as immune responses (including tendency to self-heal), all of which may vary over time. It is essential to fully describe the pathophysiology in order to make informed decisions on the most cost-effective approach. Emphasis should be on early detection of those who contribute to transmission and those who are in need of treatment, for whom short-course, effective, and safe drug regimens should be available. The prevention of PKDL should be emphasised by innovative and improved treatment for VL, which may include immunomodulation." @default.
• W2770374950 created "2017-12-04" @default.
• W2770374950 creator A5013302584 @default.
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• W2770374950 date "2017-11-16" @default.
• W2770374950 modified "2023-10-17" @default.
• W2770374950 title "Post-kala-azar dermal leishmaniasis in the Indian subcontinent: A threat to the South-East Asia Region Kala-azar Elimination Programme." @default.
• W2770374950 cites W1517798228 @default.
• W2770374950 cites W1686345002 @default.
• W2770374950 cites W1753457490 @default.
• W2770374950 cites W1825050981 @default.
• W2770374950 cites W1957126776 @default.
• W2770374950 cites W1967327441 @default.
• W2770374950 cites W1970844580 @default.
• W2770374950 cites W1976469493 @default.
• W2770374950 cites W1987566945 @default.
• W2770374950 cites W1991299349 @default.
• W2770374950 cites W1991949434 @default.
• W2770374950 cites W2006954455 @default.
• W2770374950 cites W2009237591 @default.
• W2770374950 cites W2009838296 @default.
• W2770374950 cites W2013510637 @default.
• W2770374950 cites W2015273007 @default.
• W2770374950 cites W2018393379 @default.
• W2770374950 cites W2020711392 @default.
• W2770374950 cites W2024844394 @default.
• W2770374950 cites W2025597657 @default.
• W2770374950 cites W2029057112 @default.
• W2770374950 cites W2040479272 @default.
• W2770374950 cites W2043873884 @default.
• W2770374950 cites W2047634773 @default.
• W2770374950 cites W2052800604 @default.
• W2770374950 cites W2058318327 @default.
• W2770374950 cites W2061002138 @default.
• W2770374950 cites W2067709645 @default.
• W2770374950 cites W2074642626 @default.
• W2770374950 cites W2082066472 @default.
• W2770374950 cites W2082379845 @default.
• W2770374950 cites W2091313248 @default.
• W2770374950 cites W2094091054 @default.
• W2770374950 cites W2094863418 @default.
• W2770374950 cites W2095527325 @default.
• W2770374950 cites W2097973390 @default.
• W2770374950 cites W2100502801 @default.
• W2770374950 cites W2110540038 @default.
• W2770374950 cites W2111222818 @default.
• W2770374950 cites W2121932349 @default.
• W2770374950 cites W2123497591 @default.
• W2770374950 cites W2131358046 @default.
• W2770374950 cites W2133675087 @default.
• W2770374950 cites W2133839431 @default.
• W2770374950 cites W2141233283 @default.
• W2770374950 cites W2144756920 @default.
• W2770374950 cites W2148433963 @default.
• W2770374950 cites W2152475239 @default.
• W2770374950 cites W2164425159 @default.
• W2770374950 cites W2168520931 @default.
• W2770374950 cites W2261523102 @default.
• W2770374950 cites W2301061954 @default.
• W2770374950 cites W2322032713 @default.
• W2770374950 cites W2396951803 @default.
• W2770374950 cites W2397187791 @default.
• W2770374950 cites W2405563839 @default.
• W2770374950 cites W2432468500 @default.
• W2770374950 cites W2495593729 @default.
• W2770374950 cites W2514075597 @default.
• W2770374950 cites W2535708890 @default.
• W2770374950 cites W2562666964 @default.
• W2770374950 cites W2587527269 @default.
• W2770374950 cites W2598669692 @default.
• W2770374950 cites W2599097334 @default.
• W2770374950 cites W2613163210 @default.
• W2770374950 cites W2614458392 @default.
• W2770374950 cites W341577153 @default.
• W2770374950 cites W4205711593 @default.
• W2770374950 cites W4231256920 @default.
• W2770374950 cites W4290259747 @default.
• W2770374950 doi "https://doi.org/10.1371/journal.pntd.0005877" @default.
• W2770374950 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5689828" @default.
• W2770374950 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29145397" @default.
• W2770374950 hasPublicationYear "2017" @default.
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