Matches in SemOpenAlex for { <https://semopenalex.org/work/W2770396060> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2770396060 abstract "To investigate the toxicity of topical glaucoma medications using cultured stratified human corneal epithelial sheets (HCES).HCES were exposed for 30 minutes to the following glaucoma medications: 0.1% brimonidine with sodium chlorite as the preservative, 0.005% latanoprost with 0.02% benzalkonium chloride (BAC) as the preservative, and 0.5% timolol with 0.005% BAC as the preservative. Then, cell viability and barrier function were tested by the WST-1 assay and carboxyfluorescein permeability assay, respectively. After exposure to glaucoma medications, HCES were evaluated by hematoxylin and eosin staining, periodic acid-Schiff staining, scanning electron microscopy, and transmission electron microscopy.HCES exposed to brimonidine showed higher viability and better preservation of cell morphology and microvilli compared with cell sheets exposed to latanoprost or timolol. The carboxyfluorescein permeability assay demonstrated that the barrier function was preserved after HCES were exposed to timolol, but not after exposure to brimonidine or latanoprost. Transmission electron microscopy revealed widening of intercellular junctions with prominent deposits of glycogen or mucopolysaccharide (periodic acid-Schiff positive) after exposure of HCES to brimonidine.The toxicity of 0.1% brimonidine containing sodium chlorite for HCES was lower than that of ophthalmic preparations containing BAC. Reduction of the barrier function occurred after HCES were exposed to brimonidine because of widening of intercellular junctions." @default.
- W2770396060 created "2017-12-04" @default.
- W2770396060 creator A5001776148 @default.
- W2770396060 creator A5033514327 @default.
- W2770396060 creator A5045874082 @default.
- W2770396060 creator A5051648592 @default.
- W2770396060 creator A5081340907 @default.
- W2770396060 date "2017-11-13" @default.
- W2770396060 modified "2023-10-03" @default.
- W2770396060 title "High Permeability and Intercellular Space Widening With Brimonidine Tartrate Eye Drops in Cultured Stratified Human Corneal Epithelial Sheets" @default.
- W2770396060 cites W1775461686 @default.
- W2770396060 cites W1873138934 @default.
- W2770396060 cites W1969980370 @default.
- W2770396060 cites W1978986531 @default.
- W2770396060 cites W1982848099 @default.
- W2770396060 cites W2009814734 @default.
- W2770396060 cites W2022634017 @default.
- W2770396060 cites W2068221075 @default.
- W2770396060 cites W2073771651 @default.
- W2770396060 cites W2073775017 @default.
- W2770396060 cites W2085880065 @default.
- W2770396060 cites W2123071652 @default.
- W2770396060 cites W2146087117 @default.
- W2770396060 cites W2161548588 @default.
- W2770396060 cites W2162316179 @default.
- W2770396060 cites W2321078829 @default.
- W2770396060 cites W822952811 @default.
- W2770396060 doi "https://doi.org/10.1097/ico.0000000000001450" @default.
- W2770396060 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29135708" @default.
- W2770396060 hasPublicationYear "2017" @default.
- W2770396060 type Work @default.
- W2770396060 sameAs 2770396060 @default.
- W2770396060 citedByCount "3" @default.
- W2770396060 countsByYear W27703960602019 @default.
- W2770396060 countsByYear W27703960602020 @default.
- W2770396060 crossrefType "journal-article" @default.
- W2770396060 hasAuthorship W2770396060A5001776148 @default.
- W2770396060 hasAuthorship W2770396060A5033514327 @default.
- W2770396060 hasAuthorship W2770396060A5045874082 @default.
- W2770396060 hasAuthorship W2770396060A5051648592 @default.
- W2770396060 hasAuthorship W2770396060A5081340907 @default.
- W2770396060 hasConcept C118487528 @default.
- W2770396060 hasConcept C185592680 @default.
- W2770396060 hasConcept C2775919038 @default.
- W2770396060 hasConcept C2776740260 @default.
- W2770396060 hasConcept C2776882836 @default.
- W2770396060 hasConcept C2778073030 @default.
- W2770396060 hasConcept C2778190193 @default.
- W2770396060 hasConcept C2778527774 @default.
- W2770396060 hasConcept C43617362 @default.
- W2770396060 hasConcept C71924100 @default.
- W2770396060 hasConceptScore W2770396060C118487528 @default.
- W2770396060 hasConceptScore W2770396060C185592680 @default.
- W2770396060 hasConceptScore W2770396060C2775919038 @default.
- W2770396060 hasConceptScore W2770396060C2776740260 @default.
- W2770396060 hasConceptScore W2770396060C2776882836 @default.
- W2770396060 hasConceptScore W2770396060C2778073030 @default.
- W2770396060 hasConceptScore W2770396060C2778190193 @default.
- W2770396060 hasConceptScore W2770396060C2778527774 @default.
- W2770396060 hasConceptScore W2770396060C43617362 @default.
- W2770396060 hasConceptScore W2770396060C71924100 @default.
- W2770396060 hasLocation W27703960601 @default.
- W2770396060 hasLocation W27703960602 @default.
- W2770396060 hasOpenAccess W2770396060 @default.
- W2770396060 hasPrimaryLocation W27703960601 @default.
- W2770396060 hasRelatedWork W2001206574 @default.
- W2770396060 hasRelatedWork W2033476232 @default.
- W2770396060 hasRelatedWork W2035125652 @default.
- W2770396060 hasRelatedWork W2052966092 @default.
- W2770396060 hasRelatedWork W2054254645 @default.
- W2770396060 hasRelatedWork W2309383342 @default.
- W2770396060 hasRelatedWork W2383719445 @default.
- W2770396060 hasRelatedWork W3037975320 @default.
- W2770396060 hasRelatedWork W3127366485 @default.
- W2770396060 hasRelatedWork W3182592653 @default.
- W2770396060 isParatext "false" @default.
- W2770396060 isRetracted "false" @default.
- W2770396060 magId "2770396060" @default.
- W2770396060 workType "article" @default.