FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2770410012> ?p ?o ?g. }

• W2770410012 endingPage "420" @default.
• W2770410012 startingPage "415" @default.
• W2770410012 abstract "Background Olfactory inflammation in chronic rhinosinusitis (CRS) is associated with cytokines that may result in the death of olfactory sensory neurons. The principal signaling molecules involved in the apoptotic pathway are c-Jun N-terminal kinases (JNK). Although the JNK pathway has emerged as a key player in programmed cell death in neuroinflammation, its specific role in CRS-associated olfactory loss has not been thoroughly investigated. Methods JNK activation was studied in human tissue samples from 9 control and 11 CRS patients by immunohistochemical staining for phosphorylated c-Jun. A mouse model of inducible olfactory cytokine expression was used to experimentally control inflammation and assess JNK activation over time. Results In patients with CRS, activation of c-Jun is significantly increased relative to non-CRS control subjects, and there is an associated loss of sensory neurons. In the olfactory inflammation mouse model, prolonged induction of inflammation results in elevation of c-Jun expression and neuronal apoptosis. Conclusion Activation of neuronal JNK is a feature of chronic olfactory inflammation that is associated with neuronal apoptosis. Given that inhibition of JNK activity is neuroprotective in other settings, antagonism of this pathway may have therapeutic potential in the management of inflammatory olfactory loss or other disorders linked to olfactory neuronal apoptosis." @default.
• W2770410012 created "2017-12-04" @default.
• W2770410012 creator A5035419988 @default.
• W2770410012 creator A5050041671 @default.
• W2770410012 creator A5069187265 @default.
• W2770410012 creator A5079793698 @default.
• W2770410012 date "2017-11-28" @default.
• W2770410012 modified "2023-09-24" @default.
• W2770410012 title "Olfactory loss in chronic rhinosinusitis is associated with neuronal activation of c-Jun N-terminal kinase" @default.
• W2770410012 cites W1822745879 @default.
• W2770410012 cites W1868273134 @default.
• W2770410012 cites W1949556735 @default.
• W2770410012 cites W1969277106 @default.
• W2770410012 cites W1972665345 @default.
• W2770410012 cites W1978005744 @default.
• W2770410012 cites W1983636517 @default.
• W2770410012 cites W1986940375 @default.
• W2770410012 cites W1989123797 @default.
• W2770410012 cites W1989387391 @default.
• W2770410012 cites W1995335649 @default.
• W2770410012 cites W2009548911 @default.
• W2770410012 cites W2012158235 @default.
• W2770410012 cites W2016246684 @default.
• W2770410012 cites W2022035055 @default.
• W2770410012 cites W2023393923 @default.
• W2770410012 cites W2033281822 @default.
• W2770410012 cites W2044253469 @default.
• W2770410012 cites W2045988942 @default.
• W2770410012 cites W2046417552 @default.
• W2770410012 cites W2052474826 @default.
• W2770410012 cites W2052902024 @default.
• W2770410012 cites W2053615390 @default.
• W2770410012 cites W2062301008 @default.
• W2770410012 cites W2066027939 @default.
• W2770410012 cites W2074494535 @default.
• W2770410012 cites W2085993356 @default.
• W2770410012 cites W2100659529 @default.
• W2770410012 cites W2119807130 @default.
• W2770410012 cites W2120234429 @default.
• W2770410012 cites W2123838494 @default.
• W2770410012 cites W2130518301 @default.
• W2770410012 cites W2142850882 @default.
• W2770410012 cites W2146782842 @default.
• W2770410012 cites W2148741635 @default.
• W2770410012 cites W2201873983 @default.
• W2770410012 cites W2288388572 @default.
• W2770410012 cites W2330737645 @default.
• W2770410012 cites W2332505255 @default.
• W2770410012 cites W2397441887 @default.
• W2770410012 cites W2409613884 @default.
• W2770410012 cites W2554408383 @default.
• W2770410012 cites W2735123002 @default.
• W2770410012 cites W64912384 @default.
• W2770410012 doi "https://doi.org/10.1002/alr.22053" @default.
• W2770410012 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5842118" @default.
• W2770410012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29193850" @default.
• W2770410012 hasPublicationYear "2017" @default.
• W2770410012 type Work @default.
• W2770410012 sameAs 2770410012 @default.
• W2770410012 citedByCount "20" @default.
• W2770410012 countsByYear W27704100122018 @default.
• W2770410012 countsByYear W27704100122019 @default.
• W2770410012 countsByYear W27704100122020 @default.
• W2770410012 countsByYear W27704100122021 @default.
• W2770410012 countsByYear W27704100122022 @default.
• W2770410012 countsByYear W27704100122023 @default.
• W2770410012 crossrefType "journal-article" @default.
• W2770410012 hasAuthorship W2770410012A5035419988 @default.
• W2770410012 hasAuthorship W2770410012A5050041671 @default.
• W2770410012 hasAuthorship W2770410012A5069187265 @default.
• W2770410012 hasAuthorship W2770410012A5079793698 @default.
• W2770410012 hasBestOaLocation W27704100122 @default.
• W2770410012 hasConcept C104317684 @default.
• W2770410012 hasConcept C118552586 @default.
• W2770410012 hasConcept C126322002 @default.
• W2770410012 hasConcept C169760540 @default.
• W2770410012 hasConcept C184235292 @default.
• W2770410012 hasConcept C190283241 @default.
• W2770410012 hasConcept C201792869 @default.
• W2770410012 hasConcept C203014093 @default.
• W2770410012 hasConcept C25498285 @default.
• W2770410012 hasConcept C2776914184 @default.
• W2770410012 hasConcept C2779087070 @default.
• W2770410012 hasConcept C2779830541 @default.
• W2770410012 hasConcept C55493867 @default.
• W2770410012 hasConcept C62478195 @default.
• W2770410012 hasConcept C71924100 @default.
• W2770410012 hasConcept C86339819 @default.
• W2770410012 hasConcept C86803240 @default.
• W2770410012 hasConcept C87753298 @default.
• W2770410012 hasConcept C95444343 @default.
• W2770410012 hasConceptScore W2770410012C104317684 @default.
• W2770410012 hasConceptScore W2770410012C118552586 @default.
• W2770410012 hasConceptScore W2770410012C126322002 @default.
• W2770410012 hasConceptScore W2770410012C169760540 @default.
• W2770410012 hasConceptScore W2770410012C184235292 @default.
• W2770410012 hasConceptScore W2770410012C190283241 @default.
• W2770410012 hasConceptScore W2770410012C201792869 @default.

• next