FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2770412717> ?p ?o ?g. }

• W2770412717 endingPage "290" @default.
• W2770412717 startingPage "276" @default.
• W2770412717 abstract "What is the central question of this study? What are the contributions of allopregnanolone, the neuroactive metabolite of progesterone, and nuclear (nPR) and membrane (mPR) progesterone receptors to the respiratory effect of progesterone in newborn rats? What is the main finding and its importance? Acute progesterone injection increases the apnoea frequency, whereas finasteride (which blocks the conversion of progesterone to allopregnanolone) reduces apnoea frequency. An nPR agonist decreases apnoea frequency in males and an mPR agonist decreases apnoea frequency in males and females. Chronic injection of progesterone decreases the frequency of apnoea more efficiently in males than in females. We tested the hypothesis that the effects of progesterone on apnoea frequency in newborn rats are the result of a balance between its neuroactive metabolite, allopregnanolone (GABAA receptor modulator), and progesterone receptors. We used male and female rats between 10 and 12 days of age and recorded respiratory and metabolic parameters (whole-body plethysmography), and assessed the frequency and duration of apnoeas in normoxia. We tested the effects of a single injection of progesterone (4 mg kg-1 , i.p.), finasteride (10 mg kg-1 , i.p.; a 5α-reductase antagonist, which blocks the conversion of progesterone to allopregnanolone), finasteride plus progesterone, or agonists of the nuclear or membrane progesterone receptors (R5020 or Org-od-02-0, 4 mg kg-1 ). To test the hypothesis that chronic exposure to progesterone reduces the frequency of apnoeas, we used male and female rats treated daily with progesterone between postnatal days 3 and 12. The acute injection of progesterone reduced minute ventilation and metabolic rate and increased the frequency of apnoeas. Finasteride decreased the frequency of apnoeas, and finasteride plus progesterone did not increase apnoea frequency but decreased minute ventilation in female rats. Although R5020 decreased apnoea frequency only in males, Org-od-02-0 decreased apnoea frequency in males and females and decreased respiratory frequency in females. Chronic progesterone treatment reduced apnoea frequency more efficiently in males than in females, but in females (not in males) an acute injection of caffeine (the gold standard for the treatment of apnoea in preterm neonates) further reduced apnoea frequency. Apnoea frequency in newborn rats is, in part, determined by a sex-specific balance between allopregnanolone, GABAA receptors and progesterone receptors." @default.
• W2770412717 created "2017-12-04" @default.
• W2770412717 creator A5004413440 @default.
• W2770412717 creator A5016056008 @default.
• W2770412717 creator A5026647921 @default.
• W2770412717 creator A5074578101 @default.
• W2770412717 creator A5085625392 @default.
• W2770412717 creator A5090890036 @default.
• W2770412717 date "2018-01-14" @default.
• W2770412717 modified "2023-10-16" @default.
• W2770412717 title "Respiratory regulation by steroids in newborn rats: a sex-specific balance between allopregnanolone and progesterone receptors" @default.
• W2770412717 cites W1523869695 @default.
• W2770412717 cites W1556986139 @default.
• W2770412717 cites W1639459522 @default.
• W2770412717 cites W177094347 @default.
• W2770412717 cites W1790791012 @default.
• W2770412717 cites W1939084108 @default.
• W2770412717 cites W1962587459 @default.
• W2770412717 cites W1970717054 @default.
• W2770412717 cites W1970876118 @default.
• W2770412717 cites W1973198955 @default.
• W2770412717 cites W1989173141 @default.
• W2770412717 cites W1990161760 @default.
• W2770412717 cites W1990980794 @default.
• W2770412717 cites W1992098768 @default.
• W2770412717 cites W1992832987 @default.
• W2770412717 cites W1997792093 @default.
• W2770412717 cites W2007218685 @default.
• W2770412717 cites W2009301083 @default.
• W2770412717 cites W2012255717 @default.
• W2770412717 cites W2027010610 @default.
• W2770412717 cites W2027642061 @default.
• W2770412717 cites W2033693083 @default.
• W2770412717 cites W2037299897 @default.
• W2770412717 cites W2041355825 @default.
• W2770412717 cites W2045250415 @default.
• W2770412717 cites W2050583019 @default.
• W2770412717 cites W2053787443 @default.
• W2770412717 cites W2054737043 @default.
• W2770412717 cites W2062190298 @default.
• W2770412717 cites W2063339571 @default.
• W2770412717 cites W2066718295 @default.
• W2770412717 cites W2075458520 @default.
• W2770412717 cites W2084080481 @default.
• W2770412717 cites W2094813942 @default.
• W2770412717 cites W2105216388 @default.
• W2770412717 cites W2105824687 @default.
• W2770412717 cites W2113179569 @default.
• W2770412717 cites W2122812350 @default.
• W2770412717 cites W2133415101 @default.
• W2770412717 cites W2137548343 @default.
• W2770412717 cites W2140255323 @default.
• W2770412717 cites W2157609159 @default.
• W2770412717 cites W2172264072 @default.
• W2770412717 cites W2198784994 @default.
• W2770412717 cites W2225959205 @default.
• W2770412717 cites W22744554 @default.
• W2770412717 cites W2330094320 @default.
• W2770412717 cites W2338694641 @default.
• W2770412717 cites W2484182643 @default.
• W2770412717 cites W2544651403 @default.
• W2770412717 cites W2549821527 @default.
• W2770412717 cites W2587083779 @default.
• W2770412717 cites W2588212704 @default.
• W2770412717 cites W2591373597 @default.
• W2770412717 cites W4238911087 @default.
• W2770412717 doi "https://doi.org/10.1113/ep086716" @default.
• W2770412717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29168593" @default.
• W2770412717 hasPublicationYear "2018" @default.
• W2770412717 type Work @default.
• W2770412717 sameAs 2770412717 @default.
• W2770412717 citedByCount "16" @default.
• W2770412717 countsByYear W27704127172017 @default.
• W2770412717 countsByYear W27704127172018 @default.
• W2770412717 countsByYear W27704127172019 @default.
• W2770412717 countsByYear W27704127172020 @default.
• W2770412717 countsByYear W27704127172021 @default.
• W2770412717 countsByYear W27704127172022 @default.
• W2770412717 countsByYear W27704127172023 @default.
• W2770412717 crossrefType "journal-article" @default.
• W2770412717 hasAuthorship W2770412717A5004413440 @default.
• W2770412717 hasAuthorship W2770412717A5016056008 @default.
• W2770412717 hasAuthorship W2770412717A5026647921 @default.
• W2770412717 hasAuthorship W2770412717A5074578101 @default.
• W2770412717 hasAuthorship W2770412717A5085625392 @default.
• W2770412717 hasAuthorship W2770412717A5090890036 @default.
• W2770412717 hasBestOaLocation W27704127171 @default.
• W2770412717 hasConcept C121608353 @default.
• W2770412717 hasConcept C126322002 @default.
• W2770412717 hasConcept C134018914 @default.
• W2770412717 hasConcept C168258287 @default.
• W2770412717 hasConcept C170493617 @default.
• W2770412717 hasConcept C2775874879 @default.
• W2770412717 hasConcept C2776235491 @default.
• W2770412717 hasConcept C2776801781 @default.
• W2770412717 hasConcept C2777477808 @default.
• W2770412717 hasConcept C2778338918 @default.
• W2770412717 hasConcept C2778938600 @default.

• next