FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2770454322> ?p ?o ?g. }

• W2770454322 endingPage "408" @default.
• W2770454322 startingPage "399" @default.
• W2770454322 abstract "Purpose: Cocrystallisation of drug with coformers is a promising approach to alter the solid sate properties of drug substances like solubility and dissolution. The objective of the present work was to prepare, formulate and evaluate the piroxicam cocrystal by screening various coformers. Methods: Cocrystals of piroxicam were prepared by dry grinding method. The melting point and solubility of crystalline phase was determined. The potential cocrystal was characterized by DSC, IR, XRPD. Other pharmaceutical properties like solubility and dissolution rate were also evaluated. Orodispersible tablets of piroxicam cocrystal were formulated, optimized and evaluated using 32 factorial design. Results: Cocrystals of piroxicam-sodium acetate revealed the variation in melting points and solubility. The cocrystals were obtained in 1:1 ratio with sodium acetate. The analysis of Infrared explicitly indicated the shifting of characteristic bands of piroxicam. The X-Ray Powder Diffraction pattern denoted the crystallinity of cocrystals and noteworthy difference in 2θ value of intense peaks. Differential scanning calorimetry spectra of cocrystals indicated altered endotherms corresponding to melting point. The pH solubility profile of piroxicam showed sigmoidal curve, which authenticated the pKa-dependent solubility. Piroxicam cocrystals also exhibited a similar pH-solubility profile. The cocrystals exhibited faster dissolution rate owing to cocrystallization as evident from 30% increase in the extent of dissolution. The orodispersible tablets of piroxicam cocrystals were successfully prepared by direct compression method using crosscarmelose sodium as superdisintegrant with improved disintegration time (30 sec) and dissolution rate.Conclusion: The piroxicam cocrystal with modified properties was prepared with sodium acetate and formulated as orodispersible tablets having faster disintegration and greater dissolution rate." @default.
• W2770454322 created "2017-12-04" @default.
• W2770454322 creator A5010421844 @default.
• W2770454322 creator A5011758630 @default.
• W2770454322 creator A5032770826 @default.
• W2770454322 creator A5075497805 @default.
• W2770454322 date "2017-09-25" @default.
• W2770454322 modified "2023-10-10" @default.
• W2770454322 title "Pharmaceutical Cocrystal of Piroxicam: Design, Formulation and Evaluation" @default.
• W2770454322 cites W1699507254 @default.
• W2770454322 cites W1849331108 @default.
• W2770454322 cites W1922207368 @default.
• W2770454322 cites W1965722089 @default.
• W2770454322 cites W1981588418 @default.
• W2770454322 cites W1985405389 @default.
• W2770454322 cites W1990329196 @default.
• W2770454322 cites W1990909186 @default.
• W2770454322 cites W1992287292 @default.
• W2770454322 cites W1992964622 @default.
• W2770454322 cites W1995008519 @default.
• W2770454322 cites W2005574399 @default.
• W2770454322 cites W2007068142 @default.
• W2770454322 cites W2010569817 @default.
• W2770454322 cites W2014855732 @default.
• W2770454322 cites W2019519409 @default.
• W2770454322 cites W2020722862 @default.
• W2770454322 cites W2030593028 @default.
• W2770454322 cites W2053142261 @default.
• W2770454322 cites W2056706988 @default.
• W2770454322 cites W2067129640 @default.
• W2770454322 cites W2069987077 @default.
• W2770454322 cites W2071919311 @default.
• W2770454322 cites W2093617498 @default.
• W2770454322 cites W2094340050 @default.
• W2770454322 cites W2126116995 @default.
• W2770454322 cites W2126131661 @default.
• W2770454322 cites W2133061394 @default.
• W2770454322 cites W2143408925 @default.
• W2770454322 cites W2146886080 @default.
• W2770454322 cites W2153130882 @default.
• W2770454322 cites W2580562381 @default.
• W2770454322 doi "https://doi.org/10.15171/apb.2017.048" @default.
• W2770454322 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5651061" @default.
• W2770454322 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29071222" @default.
• W2770454322 hasPublicationYear "2017" @default.
• W2770454322 type Work @default.
• W2770454322 sameAs 2770454322 @default.
• W2770454322 citedByCount "37" @default.
• W2770454322 countsByYear W27704543222018 @default.
• W2770454322 countsByYear W27704543222019 @default.
• W2770454322 countsByYear W27704543222020 @default.
• W2770454322 countsByYear W27704543222021 @default.
• W2770454322 countsByYear W27704543222022 @default.
• W2770454322 countsByYear W27704543222023 @default.
• W2770454322 crossrefType "journal-article" @default.
• W2770454322 hasAuthorship W2770454322A5010421844 @default.
• W2770454322 hasAuthorship W2770454322A5011758630 @default.
• W2770454322 hasAuthorship W2770454322A5032770826 @default.
• W2770454322 hasAuthorship W2770454322A5075497805 @default.
• W2770454322 hasBestOaLocation W27704543221 @default.
• W2770454322 hasConcept C100687433 @default.
• W2770454322 hasConcept C112887158 @default.
• W2770454322 hasConcept C121332964 @default.
• W2770454322 hasConcept C13530604 @default.
• W2770454322 hasConcept C13965031 @default.
• W2770454322 hasConcept C142724271 @default.
• W2770454322 hasConcept C155574463 @default.
• W2770454322 hasConcept C178790620 @default.
• W2770454322 hasConcept C185039092 @default.
• W2770454322 hasConcept C185592680 @default.
• W2770454322 hasConcept C192562407 @default.
• W2770454322 hasConcept C204787440 @default.
• W2770454322 hasConcept C2778139025 @default.
• W2770454322 hasConcept C2781041046 @default.
• W2770454322 hasConcept C32909587 @default.
• W2770454322 hasConcept C39519442 @default.
• W2770454322 hasConcept C46275449 @default.
• W2770454322 hasConcept C71924100 @default.
• W2770454322 hasConcept C8010536 @default.
• W2770454322 hasConcept C88380143 @default.
• W2770454322 hasConcept C97355855 @default.
• W2770454322 hasConceptScore W2770454322C100687433 @default.
• W2770454322 hasConceptScore W2770454322C112887158 @default.
• W2770454322 hasConceptScore W2770454322C121332964 @default.
• W2770454322 hasConceptScore W2770454322C13530604 @default.
• W2770454322 hasConceptScore W2770454322C13965031 @default.
• W2770454322 hasConceptScore W2770454322C142724271 @default.
• W2770454322 hasConceptScore W2770454322C155574463 @default.
• W2770454322 hasConceptScore W2770454322C178790620 @default.
• W2770454322 hasConceptScore W2770454322C185039092 @default.
• W2770454322 hasConceptScore W2770454322C185592680 @default.
• W2770454322 hasConceptScore W2770454322C192562407 @default.
• W2770454322 hasConceptScore W2770454322C204787440 @default.
• W2770454322 hasConceptScore W2770454322C2778139025 @default.
• W2770454322 hasConceptScore W2770454322C2781041046 @default.
• W2770454322 hasConceptScore W2770454322C32909587 @default.
• W2770454322 hasConceptScore W2770454322C39519442 @default.
• W2770454322 hasConceptScore W2770454322C46275449 @default.

• next