FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2770499085> ?p ?o ?g. }

• W2770499085 endingPage "1112" @default.
• W2770499085 startingPage "1103" @default.
• W2770499085 abstract "Resistant Acinetobacter baumannii complex associated with bloodstream infections is a major concern in hospitalized patients. Aminoglycosides resistance in Acinetobacter baumannii complex is mainly caused by enzymatic modification of aminoglycosides. This study was designed to identify the prevalence of aminoglycosides resistance and its association with aminoglycosides modifying enzymes (AMEs) genes and armA gene for 16S rRNA methylase among Acinetobacter baumannii complex causing bloodstream infections in patients of Mansoura University Hospitals (MUHs). Also, to evaluate the effect of aminglycosides combinations on extensively resistant strains to all tested agents. Blood culture samples were collected from patients with signs and symptoms of blood stream infections. Acinetobacter baumannii complex were identified by API 20 NE. Antibiotic susceptibilities testing were performed by disc diffusion method. Activity of amikacin and gentamicin was evaluated in vitro in combination with ciprofloxacin and imipenem against resistant strains of Acinetobacter baumannii complex to all tested antibiotics using checkerboard titration method and the fractional inhibitory concentration index (FICI) was calculated for each combination. Resistant Acinetobacter baumannii complex were tested for presence of aac(3)-I, ant(2'')-Ia, aac(6')-I h, aac(6')-I b, aph (3')-V1 AME genes and armA gene for 16S rRNA methylase using PCR. A total of 67 Acinetobacter baumannii complex isolates were collected during the period of the study. Forty-one isolates (61.2%) were resistant to gentamicin and/ or amikacin. There were 15 isolates resistant to all tested antibiotics agents. Amikacin combination with ciprofloxacin and imipenem showed the highest synergistic effect against 40%, 33.3% respectively of these extensively drug resistant A. baumannii complex isolates. Combination of gentamicin-ciprofloxacin and gentamicin-imipenem each showed synergistic effect against 26.7% of these isolates. The most commonly encountered AME genes were aac(6')-I b and aac(3)-I (70.7% and 65.8% respectively). ArmA 16S rRNA methylase gene was encountered in 56.1% of resistant strains. The most prevalent gene profile was aac(3)-I + aac(6')-Ib + ant(2'')-Ia + armA detected in 31.7% of resistant isolates. The extensively resistant strains mostly express the gene pattern aac(3)-I + aac(6')-Ib + ant(2'')-Ia +armA (6/15). This study concluded that aminoglycosides modifying enzymes are widespread in aminoglycosides resistant A. baumannii complex causing bloodstream infections. Combination therapy including amikacin and gentamicin with ciprofloxacin and imipenem can be used as for treatment of severe resistant A. baumannii blood stream infection." @default.
• W2770499085 created "2017-12-04" @default.
• W2770499085 creator A5038109762 @default.
• W2770499085 date "2017-11-10" @default.
• W2770499085 modified "2023-09-23" @default.
• W2770499085 title "Aminoglycosides Resistance among Acinetobacter baumannii Complex Isolated from Hospital Acquired Blood Stream Infections" @default.
• W2770499085 cites W1960965614 @default.
• W2770499085 cites W1971642712 @default.
• W2770499085 cites W2020661238 @default.
• W2770499085 cites W2028051811 @default.
• W2770499085 cites W2031792588 @default.
• W2770499085 cites W2082853206 @default.
• W2770499085 cites W2106753350 @default.
• W2770499085 cites W2110424949 @default.
• W2770499085 cites W2117064229 @default.
• W2770499085 cites W2142343447 @default.
• W2770499085 cites W2146049144 @default.
• W2770499085 cites W2149088130 @default.
• W2770499085 cites W2553964711 @default.
• W2770499085 doi "https://doi.org/10.20546/ijcmas.2017.611.130" @default.
• W2770499085 hasPublicationYear "2017" @default.
• W2770499085 type Work @default.
• W2770499085 sameAs 2770499085 @default.
• W2770499085 citedByCount "3" @default.
• W2770499085 countsByYear W27704990852019 @default.
• W2770499085 countsByYear W27704990852020 @default.
• W2770499085 countsByYear W27704990852023 @default.
• W2770499085 crossrefType "journal-article" @default.
• W2770499085 hasAuthorship W2770499085A5038109762 @default.
• W2770499085 hasBestOaLocation W27704990851 @default.
• W2770499085 hasConcept C2775832221 @default.
• W2770499085 hasConcept C2776315533 @default.
• W2770499085 hasConcept C2777427914 @default.
• W2770499085 hasConcept C2777637488 @default.
• W2770499085 hasConcept C2778512257 @default.
• W2770499085 hasConcept C2778523567 @default.
• W2770499085 hasConcept C2779631663 @default.
• W2770499085 hasConcept C501593827 @default.
• W2770499085 hasConcept C523546767 @default.
• W2770499085 hasConcept C54355233 @default.
• W2770499085 hasConcept C71924100 @default.
• W2770499085 hasConcept C86803240 @default.
• W2770499085 hasConcept C89423630 @default.
• W2770499085 hasConcept C94665300 @default.
• W2770499085 hasConceptScore W2770499085C2775832221 @default.
• W2770499085 hasConceptScore W2770499085C2776315533 @default.
• W2770499085 hasConceptScore W2770499085C2777427914 @default.
• W2770499085 hasConceptScore W2770499085C2777637488 @default.
• W2770499085 hasConceptScore W2770499085C2778512257 @default.
• W2770499085 hasConceptScore W2770499085C2778523567 @default.
• W2770499085 hasConceptScore W2770499085C2779631663 @default.
• W2770499085 hasConceptScore W2770499085C501593827 @default.
• W2770499085 hasConceptScore W2770499085C523546767 @default.
• W2770499085 hasConceptScore W2770499085C54355233 @default.
• W2770499085 hasConceptScore W2770499085C71924100 @default.
• W2770499085 hasConceptScore W2770499085C86803240 @default.
• W2770499085 hasConceptScore W2770499085C89423630 @default.
• W2770499085 hasConceptScore W2770499085C94665300 @default.
• W2770499085 hasIssue "11" @default.
• W2770499085 hasLocation W27704990851 @default.
• W2770499085 hasOpenAccess W2770499085 @default.
• W2770499085 hasPrimaryLocation W27704990851 @default.
• W2770499085 hasRelatedWork W1516157133 @default.
• W2770499085 hasRelatedWork W1946172002 @default.
• W2770499085 hasRelatedWork W2063373680 @default.
• W2770499085 hasRelatedWork W2112510458 @default.
• W2770499085 hasRelatedWork W2125488686 @default.
• W2770499085 hasRelatedWork W2146583750 @default.
• W2770499085 hasRelatedWork W2146655798 @default.
• W2770499085 hasRelatedWork W2891320425 @default.
• W2770499085 hasRelatedWork W2996376688 @default.
• W2770499085 hasRelatedWork W3011145298 @default.
• W2770499085 hasVolume "6" @default.
• W2770499085 isParatext "false" @default.
• W2770499085 isRetracted "false" @default.
• W2770499085 magId "2770499085" @default.
• W2770499085 workType "article" @default.