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- W2770553911 abstract "Mucosal epithelia encounter both physicochemical and biological stress during their life and have evolved several mechanisms to deal with them, including regulation of immune cell functions. Stressed and damaged cells need to be cleared to control local inflammation and trigger tissue healing. Engagement of the activating NKG2D receptor is one of the most direct mechanisms involved in the recognition of stressed cells by the immune system. Indeed, injured cells promptly express NKG2D ligands that in turn mediate the activation of lymphocytes of both innate and adaptive arms of the immune system. This review focuses on different conditions that are able to modulate NKG2D ligand expression on the epithelia. Special attention is given to the mechanisms of immunosurveillance mediated by natural killer cells, which are finely tuned by NKG2D. Different types of stress, including viral and bacterial infections, chronic inflammation, and cigarette smoke exposure, are discussed as paradigmatic conditions for NKG2D ligand modulation, and the implications for tissue homeostasis are discussed." @default.
- W2770553911 created "2017-12-04" @default.
- W2770553911 creator A5024871281 @default.
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- W2770553911 creator A5086891953 @default.
- W2770553911 date "2017-11-20" @default.
- W2770553911 modified "2023-10-18" @default.
- W2770553911 title "How Mucosal Epithelia Deal with Stress: Role of NKG2D/NKG2D Ligands during Inflammation" @default.
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- W2770553911 doi "https://doi.org/10.3389/fimmu.2017.01583" @default.
- W2770553911 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5701928" @default.
- W2770553911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29209320" @default.
- W2770553911 hasPublicationYear "2017" @default.
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