FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2770575058> ?p ?o ?g. }

• W2770575058 endingPage "30" @default.
• W2770575058 startingPage "17" @default.
• W2770575058 abstract "The sex hormone testosterone (TTS) and the hypothalamic–pituitary–adrenal (HPA) axis mutually control one another’s activity, wherein TTS suppresses corticotrophin releasing hormone (CRH) stimulated HPA axis activity, whereas the activation of HPA axis has an inhibitory effect on TTS secretion. With an intention to explain these phenomena, a network reaction model is developed from the previously postulated stoichiometric models for HPA activity where main dynamic behaviors are controlled by two catalytic steps (one autocatalytic and one autoinhibitory) with respect to cortisol, both found experimentally. The capacity of the model to emulate TTS effects on HPA axis dynamics and its response to acute CRH-induced stress is examined using numerical simulations. Model predictions are compared with empirically obtained results reported in the literature. Thus, the reaction kinetic examinations of nonlinear biochemical transformations that constitute the HPA axis, including the negative feedback effect of TTS on HPA axis activity, recapitulates the well-established fact that TTS dampens HPA axis basal activity, decreasing both cortisol level and the amplitude of ultradian cortisol oscillations. The model also replicates TTS inhibitory action on the HPA axis response to acute environmental challenges, particularly CRH-induced stress. In addition, kinetic modelling revealed that TTS induced reduction in ultradian cortisol amplitude arises because the system moves towards a supercritical Hopf bifurcation as TTS is being increased." @default.
• W2770575058 created "2017-12-04" @default.
• W2770575058 creator A5003230044 @default.
• W2770575058 creator A5019852037 @default.
• W2770575058 creator A5021022098 @default.
• W2770575058 creator A5023579543 @default.
• W2770575058 creator A5056877512 @default.
• W2770575058 date "2017-11-17" @default.
• W2770575058 modified "2023-10-15" @default.
• W2770575058 title "Kinetic modelling of testosterone-related differences in the hypothalamic–pituitary–adrenal axis response to stress" @default.
• W2770575058 cites W1492699395 @default.
• W2770575058 cites W1578343521 @default.
• W2770575058 cites W1964357295 @default.
• W2770575058 cites W1971639265 @default.
• W2770575058 cites W1996579832 @default.
• W2770575058 cites W2002232774 @default.
• W2770575058 cites W2003656057 @default.
• W2770575058 cites W2004063045 @default.
• W2770575058 cites W2019062333 @default.
• W2770575058 cites W2037938652 @default.
• W2770575058 cites W2046468941 @default.
• W2770575058 cites W2046960533 @default.
• W2770575058 cites W2067132822 @default.
• W2770575058 cites W2068615526 @default.
• W2770575058 cites W2072154896 @default.
• W2770575058 cites W2087881963 @default.
• W2770575058 cites W2095127814 @default.
• W2770575058 cites W2110243057 @default.
• W2770575058 cites W2114608871 @default.
• W2770575058 cites W2115871268 @default.
• W2770575058 cites W2127479912 @default.
• W2770575058 cites W2161277545 @default.
• W2770575058 cites W2303402394 @default.
• W2770575058 cites W2307321386 @default.
• W2770575058 cites W2395570864 @default.
• W2770575058 cites W2413515606 @default.
• W2770575058 cites W2620357294 @default.
• W2770575058 cites W2790679843 @default.
• W2770575058 cites W941271829 @default.
• W2770575058 doi "https://doi.org/10.1007/s11144-017-1315-7" @default.
• W2770575058 hasPublicationYear "2017" @default.
• W2770575058 type Work @default.
• W2770575058 sameAs 2770575058 @default.
• W2770575058 citedByCount "8" @default.
• W2770575058 countsByYear W27705750582019 @default.
• W2770575058 countsByYear W27705750582020 @default.
• W2770575058 countsByYear W27705750582021 @default.
• W2770575058 countsByYear W27705750582022 @default.
• W2770575058 countsByYear W27705750582023 @default.
• W2770575058 crossrefType "journal-article" @default.
• W2770575058 hasAuthorship W2770575058A5003230044 @default.
• W2770575058 hasAuthorship W2770575058A5019852037 @default.
• W2770575058 hasAuthorship W2770575058A5021022098 @default.
• W2770575058 hasAuthorship W2770575058A5023579543 @default.
• W2770575058 hasAuthorship W2770575058A5056877512 @default.
• W2770575058 hasBestOaLocation W27705750581 @default.
• W2770575058 hasConcept C104317684 @default.
• W2770575058 hasConcept C126322002 @default.
• W2770575058 hasConcept C134018914 @default.
• W2770575058 hasConcept C146819174 @default.
• W2770575058 hasConcept C15744967 @default.
• W2770575058 hasConcept C2778575703 @default.
• W2770575058 hasConcept C2779146795 @default.
• W2770575058 hasConcept C2779279991 @default.
• W2770575058 hasConcept C55493867 @default.
• W2770575058 hasConcept C71315377 @default.
• W2770575058 hasConcept C71924100 @default.
• W2770575058 hasConcept C78604142 @default.
• W2770575058 hasConcept C86803240 @default.
• W2770575058 hasConceptScore W2770575058C104317684 @default.
• W2770575058 hasConceptScore W2770575058C126322002 @default.
• W2770575058 hasConceptScore W2770575058C134018914 @default.
• W2770575058 hasConceptScore W2770575058C146819174 @default.
• W2770575058 hasConceptScore W2770575058C15744967 @default.
• W2770575058 hasConceptScore W2770575058C2778575703 @default.
• W2770575058 hasConceptScore W2770575058C2779146795 @default.
• W2770575058 hasConceptScore W2770575058C2779279991 @default.
• W2770575058 hasConceptScore W2770575058C55493867 @default.
• W2770575058 hasConceptScore W2770575058C71315377 @default.
• W2770575058 hasConceptScore W2770575058C71924100 @default.
• W2770575058 hasConceptScore W2770575058C78604142 @default.
• W2770575058 hasConceptScore W2770575058C86803240 @default.
• W2770575058 hasFunder F4320320366 @default.
• W2770575058 hasFunder F4320322729 @default.
• W2770575058 hasIssue "1" @default.
• W2770575058 hasLocation W27705750581 @default.
• W2770575058 hasLocation W27705750582 @default.
• W2770575058 hasLocation W27705750583 @default.
• W2770575058 hasOpenAccess W2770575058 @default.
• W2770575058 hasPrimaryLocation W27705750581 @default.
• W2770575058 hasRelatedWork W1549089891 @default.
• W2770575058 hasRelatedWork W1966816209 @default.
• W2770575058 hasRelatedWork W1976698250 @default.
• W2770575058 hasRelatedWork W1992874805 @default.
• W2770575058 hasRelatedWork W2001051100 @default.
• W2770575058 hasRelatedWork W2001865401 @default.
• W2770575058 hasRelatedWork W2002812997 @default.
• W2770575058 hasRelatedWork W2027237635 @default.

• next