Matches in SemOpenAlex for { <https://semopenalex.org/work/W2770576985> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2770576985 abstract "Purpose: To investigate the effect of mebendazole on an in vivo solid tumor model of fibrosarcoma in hamsters.Methods: 24 Syrian golden hamsters of both sexes with the approximate body weight of 100g were randomly distributed in 2 experimental and 2 control groups, with 6 animals in each group. BHK-21/C13 cells (2 x 106) in 1 mL Glasgow Minimum Essential Medium (GMEM) were injected subcutaneously into the back of each animal in 3 groups. The experimental groups were treated with mebendazole (460 mg/kg) via a gastric tube on a daily basis, immediately after tumor inoculation. In addition, one experimental group received deoxycholic acid 20 mg/kg once a day. After 2 weeks, when the tumors were approximately 1 - 2 cm in the control group, all the animals were sacrificed, and their blood collected for laboratory analysis. The tumors were excised, their weight and diameters measured, and the volumes calculated. The tumor samples were histopathologically assessed and the main organs toxicologically analyzed. Images were taken and processed by an imaging software, and Ki-67-positive cells in the tumor samples were quantified.Results: Mebendazole diminished tumor mitosis from 18.5 ± 3.02 to 13.5 ± 3.45 (p < 0.05), vasculature and tissue penetration, and increased necroses in tumor slices. Tumor volume and weight were insignificantly attenuated. Toxicity was not observed.Conclusion: Mebendazole might be an effective non-toxic agent in sarcoma therapy.Keywords: Mebendazole, Hamsters, BHK-21/C13 cells, Fibrosarcoma therapy, Tumor mitosis" @default.
- W2770576985 created "2017-12-04" @default.
- W2770576985 creator A5027589494 @default.
- W2770576985 creator A5039605543 @default.
- W2770576985 creator A5056343785 @default.
- W2770576985 creator A5066880183 @default.
- W2770576985 creator A5067899222 @default.
- W2770576985 creator A5089911855 @default.
- W2770576985 date "2017-11-15" @default.
- W2770576985 modified "2023-10-13" @default.
- W2770576985 title "Effect of mebendazole on fibrosarcoma in hamsters" @default.
- W2770576985 doi "https://doi.org/10.4314/tjpr.v16i10.19" @default.
- W2770576985 hasPublicationYear "2017" @default.
- W2770576985 type Work @default.
- W2770576985 sameAs 2770576985 @default.
- W2770576985 citedByCount "3" @default.
- W2770576985 countsByYear W27705769852020 @default.
- W2770576985 countsByYear W27705769852021 @default.
- W2770576985 countsByYear W27705769852023 @default.
- W2770576985 crossrefType "journal-article" @default.
- W2770576985 hasAuthorship W2770576985A5027589494 @default.
- W2770576985 hasAuthorship W2770576985A5039605543 @default.
- W2770576985 hasAuthorship W2770576985A5056343785 @default.
- W2770576985 hasAuthorship W2770576985A5066880183 @default.
- W2770576985 hasAuthorship W2770576985A5067899222 @default.
- W2770576985 hasAuthorship W2770576985A5089911855 @default.
- W2770576985 hasBestOaLocation W27705769851 @default.
- W2770576985 hasConcept C126322002 @default.
- W2770576985 hasConcept C142724271 @default.
- W2770576985 hasConcept C147583825 @default.
- W2770576985 hasConcept C185592680 @default.
- W2770576985 hasConcept C18903297 @default.
- W2770576985 hasConcept C2776495794 @default.
- W2770576985 hasConcept C2778256501 @default.
- W2770576985 hasConcept C2779061029 @default.
- W2770576985 hasConcept C71924100 @default.
- W2770576985 hasConcept C86803240 @default.
- W2770576985 hasConceptScore W2770576985C126322002 @default.
- W2770576985 hasConceptScore W2770576985C142724271 @default.
- W2770576985 hasConceptScore W2770576985C147583825 @default.
- W2770576985 hasConceptScore W2770576985C185592680 @default.
- W2770576985 hasConceptScore W2770576985C18903297 @default.
- W2770576985 hasConceptScore W2770576985C2776495794 @default.
- W2770576985 hasConceptScore W2770576985C2778256501 @default.
- W2770576985 hasConceptScore W2770576985C2779061029 @default.
- W2770576985 hasConceptScore W2770576985C71924100 @default.
- W2770576985 hasConceptScore W2770576985C86803240 @default.
- W2770576985 hasLocation W27705769851 @default.
- W2770576985 hasOpenAccess W2770576985 @default.
- W2770576985 hasPrimaryLocation W27705769851 @default.
- W2770576985 hasRelatedWork W1499344837 @default.
- W2770576985 hasRelatedWork W1985041001 @default.
- W2770576985 hasRelatedWork W2057982893 @default.
- W2770576985 hasRelatedWork W2143098953 @default.
- W2770576985 hasRelatedWork W2150131600 @default.
- W2770576985 hasRelatedWork W2157176829 @default.
- W2770576985 hasRelatedWork W2398682011 @default.
- W2770576985 hasRelatedWork W2403390658 @default.
- W2770576985 hasRelatedWork W2411241556 @default.
- W2770576985 hasRelatedWork W2421367395 @default.
- W2770576985 hasRelatedWork W2440627316 @default.
- W2770576985 hasRelatedWork W2468567179 @default.
- W2770576985 hasRelatedWork W2473659380 @default.
- W2770576985 hasRelatedWork W2744207497 @default.
- W2770576985 hasRelatedWork W2888844793 @default.
- W2770576985 hasRelatedWork W2911733687 @default.
- W2770576985 hasRelatedWork W3028922555 @default.
- W2770576985 hasRelatedWork W3030056058 @default.
- W2770576985 hasRelatedWork W3032493346 @default.
- W2770576985 hasRelatedWork W2185393269 @default.
- W2770576985 isParatext "false" @default.
- W2770576985 isRetracted "false" @default.
- W2770576985 magId "2770576985" @default.
- W2770576985 workType "article" @default.