FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2770582014> ?p ?o ?g. }

• W2770582014 endingPage "313" @default.
• W2770582014 startingPage "303" @default.
• W2770582014 abstract "Parkinson’s disease (PD) is a common and progressive neurodegenerative disorder. The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD is widely used to study the progression of this disease. Behavior impairment is closely related to the damage of the dopaminergic system in the basal ganglia. Here, MPTP-induced changes in mouse behavior and glial activation were evaluated at different time points after the treatment and the long-term changes in the nigrostriatal pathway were analyzed. We found that mice exposed to MPTP displayed a full recovery in the rotarod test and the pole test but not in the wire hanging test at 65 days post-injection. A biphasic activation of microglial cells was revealed in the nigrostriatal pathway of MPTP-treated mice. However, activation of astrocytes displayed an approximately bell-shaped kinetics and an approximately S-shaped kinetics in the striatum and the substantia nigra, respectively. In addition, the numbers of complement component 3 (C3)-positive neurotoxic astrocytes in the substantia nigra of MPTP-treated mice increased with time and reached a maximum at 42 days, and declined at 74 days, after the treatment. Three months later, the dopaminergic system was partially recovered from the lesion of MPTP. The time course of pathophysiological events has important implications for the interventions or treatment of PD." @default.
• W2770582014 created "2017-12-04" @default.
• W2770582014 creator A5003723166 @default.
• W2770582014 creator A5004564984 @default.
• W2770582014 creator A5013795174 @default.
• W2770582014 creator A5029977917 @default.
• W2770582014 creator A5030202879 @default.
• W2770582014 creator A5031370753 @default.
• W2770582014 creator A5041660699 @default.
• W2770582014 creator A5041690571 @default.
• W2770582014 creator A5044945334 @default.
• W2770582014 creator A5046162972 @default.
• W2770582014 creator A5071707212 @default.
• W2770582014 creator A5073663977 @default.
• W2770582014 creator A5090107253 @default.
• W2770582014 date "2018-01-01" @default.
• W2770582014 modified "2023-10-17" @default.
• W2770582014 title "Long-term Changes in the Nigrostriatal Pathway in the MPTP Mouse Model of Parkinson’s Disease" @default.
• W2770582014 cites W1505937405 @default.
• W2770582014 cites W1530199299 @default.
• W2770582014 cites W1556003326 @default.
• W2770582014 cites W1825793612 @default.
• W2770582014 cites W1876850155 @default.
• W2770582014 cites W1928600912 @default.
• W2770582014 cites W1969800514 @default.
• W2770582014 cites W1973617717 @default.
• W2770582014 cites W1991691390 @default.
• W2770582014 cites W1992257637 @default.
• W2770582014 cites W2021193054 @default.
• W2770582014 cites W2022911097 @default.
• W2770582014 cites W2035382111 @default.
• W2770582014 cites W2037577786 @default.
• W2770582014 cites W2038647795 @default.
• W2770582014 cites W2052985285 @default.
• W2770582014 cites W2088318694 @default.
• W2770582014 cites W2095090033 @default.
• W2770582014 cites W2106433817 @default.
• W2770582014 cites W2121845150 @default.
• W2770582014 cites W2128672762 @default.
• W2770582014 cites W2148726772 @default.
• W2770582014 cites W2163543612 @default.
• W2770582014 cites W2169890833 @default.
• W2770582014 cites W2170330569 @default.
• W2770582014 cites W2172278003 @default.
• W2770582014 cites W2196585553 @default.
• W2770582014 cites W2298910974 @default.
• W2770582014 cites W2572710398 @default.
• W2770582014 cites W2589038248 @default.
• W2770582014 cites W4242174061 @default.
• W2770582014 cites W62603772 @default.
• W2770582014 doi "https://doi.org/10.1016/j.neuroscience.2017.11.041" @default.
• W2770582014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29196026" @default.
• W2770582014 hasPublicationYear "2018" @default.
• W2770582014 type Work @default.
• W2770582014 sameAs 2770582014 @default.
• W2770582014 citedByCount "21" @default.
• W2770582014 countsByYear W27705820142018 @default.
• W2770582014 countsByYear W27705820142019 @default.
• W2770582014 countsByYear W27705820142020 @default.
• W2770582014 countsByYear W27705820142021 @default.
• W2770582014 countsByYear W27705820142022 @default.
• W2770582014 countsByYear W27705820142023 @default.
• W2770582014 crossrefType "journal-article" @default.
• W2770582014 hasAuthorship W2770582014A5003723166 @default.
• W2770582014 hasAuthorship W2770582014A5004564984 @default.
• W2770582014 hasAuthorship W2770582014A5013795174 @default.
• W2770582014 hasAuthorship W2770582014A5029977917 @default.
• W2770582014 hasAuthorship W2770582014A5030202879 @default.
• W2770582014 hasAuthorship W2770582014A5031370753 @default.
• W2770582014 hasAuthorship W2770582014A5041660699 @default.
• W2770582014 hasAuthorship W2770582014A5041690571 @default.
• W2770582014 hasAuthorship W2770582014A5044945334 @default.
• W2770582014 hasAuthorship W2770582014A5046162972 @default.
• W2770582014 hasAuthorship W2770582014A5071707212 @default.
• W2770582014 hasAuthorship W2770582014A5073663977 @default.
• W2770582014 hasAuthorship W2770582014A5090107253 @default.
• W2770582014 hasConcept C126322002 @default.
• W2770582014 hasConcept C134018914 @default.
• W2770582014 hasConcept C137183658 @default.
• W2770582014 hasConcept C142724271 @default.
• W2770582014 hasConcept C15744967 @default.
• W2770582014 hasConcept C169760540 @default.
• W2770582014 hasConcept C185592680 @default.
• W2770582014 hasConcept C2776355744 @default.
• W2770582014 hasConcept C2778187257 @default.
• W2770582014 hasConcept C2778674702 @default.
• W2770582014 hasConcept C2779134260 @default.
• W2770582014 hasConcept C2779734285 @default.
• W2770582014 hasConcept C2780062018 @default.
• W2770582014 hasConcept C2780938664 @default.
• W2770582014 hasConcept C2781156865 @default.
• W2770582014 hasConcept C513476851 @default.
• W2770582014 hasConcept C529278444 @default.
• W2770582014 hasConcept C71924100 @default.
• W2770582014 hasConceptScore W2770582014C126322002 @default.
• W2770582014 hasConceptScore W2770582014C134018914 @default.
• W2770582014 hasConceptScore W2770582014C137183658 @default.
• W2770582014 hasConceptScore W2770582014C142724271 @default.

• next